Results 61 to 70 of about 10,123,914 (305)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Role of Oxygen in a Large Area of RF-Powered Atmospheric Pressure Dielectric Barrier Glow Discharge Plasma in Sterilization

, 2011
National Natural Science Foundation of China [11005151, 10735090]A nonequilibrium Ar/O(2) plasma at atmospheric pressure was generated between two parallel square electrodes by a 13.56-MHz power supplier. Experimental results demonstrate that the Ar/O(2)
Chen, Qiang, Size Yang, Li, Bin,, Hua Pang, Yang, S., Pang, H., Chen, Q., Yang, Size, Bin Li, Fei, F., Fei Fei, Li, Bin, Pang, Hua, 杨思泽, Fei, Fei, Qiang Chen   +15 more
core   +1 more source

Design considerations for the use of laser-plasma accelerators for advanced space radiation studies [PDF]

, 2012
We present design considerations for the use of laser-plasma accelerators for mimicking space radiation and testing space-grade electronics. This novel application takes advantage of the inherent ability of laser-plasma accelerators to produce particle ...
Pretzler G, Rosenzweig JB, Koenigstein, T., Hidding, B., Karger, O., Pretzler, G., Konigstein T, Rosenzweig, J. B., Hidding B, Karger O   +9 more
core   +1 more source

Different behaviour of the N-terminal and C-terminal fragment of proatrial natriuretic factor in plasma of healthy subjects as well as of patients with cirrhosis [PDF]

, 1990
N-terminal (atrial natriuretic factor (ANF) 1-98) and C-terminal (ANF 99-126) fragments of proatrial natriuretic factor (NTA and CTA, respectively) were determined in plasma of healthy subjects adopting different postures and in patients with cirrhosis ...
Arendt, Rainer M., Paumgartner, Gustav, Cantin, M., Thibault, G., Vollmar, Angelika M., Gerbes, Alexander L.   +5 more
core   +1 more source

Estimated plasma volume status is a modest predictor of true plasma volume excess in compensated chronic heart failure patients

Scientific Reports, 2021
Plasma volume and especially plasma volume excess is a relevant predictor for the clinical outcome of heart failure patients. In recent years, estimated plasma volume based on anthropometric characteristics and blood parameters has been used whilst ...
Christoph Ahlgrim, Philipp Birkner, Florian Seiler, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Sodium–Glucose Cotransporter 2 Inhibitor Combined with Conventional Diuretics Ameliorate Body Fluid Retention without Excessive Plasma Volume Reduction

Diagnostics
We previously reported that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert sustained fluid homeostatic actions through compensatory increases in osmotic diuresis-induced vasopressin secretion and fluid intake.
Maki Asakura-Kinoshita, Takahiro Masuda, Kentaro Oka, Ken Ohara, Marina Miura, Masato Morinari, Kyohei Misawa, Yasuharu Miyazawa, Tetsu Akimoto, Kazuyuki Shimada, Daisuke Nagata   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

On the development of a deployable cold plasma endoscope

, 2018
A novel non-thermal atmospheric-pressure plasma jet source for endoscopic application is presented. Specific challenges in the endoscopic plasma source development, such as small dimensions, flexibility, operation in half-closed cavities, and the ...
Thalita M.C. Nishime, Nishime, Thalita M.C. [UNESP], Klaus-Dieter Weltmann, Winter, Jörn, Weltmann, Klaus-Dieter, Sven Glitsch, Heike Lühder, Jörn Winter, Glitsch, Sven, Lühder, Heike   +9 more
core   +1 more source