Results 61 to 70 of about 1,676,600 (294)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Estimated plasma volume status is a modest predictor of true plasma volume excess in compensated chronic heart failure patients

Scientific Reports, 2021
Plasma volume and especially plasma volume excess is a relevant predictor for the clinical outcome of heart failure patients. In recent years, estimated plasma volume based on anthropometric characteristics and blood parameters has been used whilst ...
Christoph Ahlgrim, Philipp Birkner, Florian Seiler, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser   +5 more
doaj   +1 more source

Atrial natriuretic factor [PDF]

, 1987
The discovery of the first well-defined natriuretic hormone, the Atrial Natriuretic Factor (ANF), has prompted research on its impact on volume regulation in health and disease.
A.L. Gerbes, Ames, Anderson, Anderson, Arendt, Arendt, Arendt, Arendt, Atlas, Ballermann, Ballermann, Barakat, Bichet, Bichet, Biollaz, Bompiani, Bonkovsky, Bourgoignie, Brabant, Bricker, Buckalew, Burghardt, Burnett, Campbell, Chartier, Conn, Cuneo, Currie, De Wardener, DeBold, DeBold, DeWardener, Epstein, Epstein, Epstein, Epstein, Epstein, Fernandez-Cruz, Forssmann, Fyhrquist, G. Paumgartner, Ganger, Gauer, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerzer, Gerzer, Ginés, Goodfriend, Hartshorne, Henry, Jimenez, Jüppner, Kisch, Kramer, Laffi, Lang, Laragh, Maack, Manning, Marin-Grez, Morgan, Naruse, Needleman, Needleman, Nishiuchi, Nozuki, Ogihara, R.M. Arendt, Renner, Richards, Richards, Richards, Riegger, Ring-Larsen, Rosoff, Sagnella, Sagnella, Salerno, Samson, Schafferhans, Shenker, Sherlock, Shimizu, Thibault, Tikkanen, Uehlinger, Valdivieso, Wambach, Weidmann, Wernze, Wilkinson, Wong, Yamaji, Zipser   +99 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effect of Post-Warm-Up Breathing Using Additional Respiratory Dead Space Volume on Exercise Acid-Base Balance

Applied Sciences
The aim of the presented study was to compare changes in acid-base balance during high-intensity exercise preceded and not preceded by a warm-up that ended with breathing using additional respiratory dead space volume (ARDSv).
Rafał Hebisz, Natalia Danek, Paulina Hebisz   +2 more
doaj   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

High-level ePVS was accompanied by an increase in kidney transplant failure risk: analysis based on the MIMIC-IV database

Frontiers in Immunology
BackgroundThe prognosis of kidney transplantation is currently assessed primarily through clinical monitoring, which involves considerable time and financial costs.
Zhirong Zhou, Lin Zhang, Delin Zhang, Yan Yang, Shuiping Ou   +4 more
doaj   +1 more source

Thermal and non-thermal emission from reconnecting twisted coronal loops

, 2015
Twisted magnetic fields should be ubiquitous in flare-producing active regions where the magnetic fields are strongly non-potential. It has been shown that reconnection in helical magnetic coronal loops results in plasma heating and particle acceleration
Browning, P. K., Gordovskyy, M., Pinto, R. F., Vilmer, N.   +3 more
core   +2 more sources