Results 91 to 100 of about 1,300,884 (312)

Repurpose the antimicrobial peptide Buforin II for plasmid transformation into Escherichia coli

CTU Journal of Innovation and Sustainable Development
Antimicrobial peptides Buforin II, derived from histone H2A, demonstrates strong cell-penetrating activity without cell lysis and strong affinity for internal cellular nucleic acids, making it a potential candidate for macromolecule delivery into ...
Thanh Ngoc Nguyen, Le Minh Bui
doaj  

Discovering and Differentiating New and Emerging Clonal Populations of Chlamydia trachomatis with a Novel Shotgun Cell Culture Harvest Assay

Emerging Infectious Diseases, 2008
Chlamydia trachomatis is the leading cause of preventable blindness and bacterial sexually transmitted diseases worldwide. Plaque assays have been used to clonally segregate laboratory-adapted C.
Naraporn Somboonna, Sally Mead, Jessica Liu, Deborah Dean   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An open reading frame upstream from the nifH gene of Klebsiella pneumoniae [PDF]

, 1983
An open reading frame upstream from nifHDK operon of Klebsiella pneumoniae had been described. The orientation of this open reading frame is opposite to that of nifHDK and sequence homology was found between the open reading frame promoter and the ...
Kong, Qiu-tong, Shen, San-chiun, Wu, Qi-long, Xue, Zhong-tian   +3 more
core  

QQ-SNV: single nucleotide variant detection at low frequency by comparing the quality quantiles [PDF]

, 2015
Background: Next generation sequencing enables studying heterogeneous populations of viral infections. When the sequencing is done at high coverage depth ("deep sequencing"), low frequency variants can be detected.
Aerssens, Jeroen, Clement, Lieven, Reumers, Joke, Thys, Kim, van der Borght, Koen, van Vlijmen, Herman, Verbist, Bie, Wetzels, Yves   +7 more
core   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Requirement of a Plasmid-Encoded Catalase for Survival of \u3cem\u3eRhizobium etli\u3c/em\u3e CFN42 in a Polyphenol-Rich Environment [PDF]

, 2008
Nitrogen-fixing bacteria collectively called rhizobia are adapted to live in polyphenol-rich environments. The mechanisms that allow these bacteria to overcome toxic concentrations of plant polyphenols have not been clearly elucidated.
Brom, Susana, Cubillas, Ciro A., García-de los Santos, Alejandro, López, Erika, Noel, K. Dale, Romero, David   +5 more
core   +1 more source

Optimization of an in vitro transcription/translation system based on Sulfolobus solfataricus cell lysate. [PDF]

, 2018
A system is described which permits the efficient synthesis of proteins in vitro at high temperature. It is based on the use of an unfractionated cell lysate (S30) from Sulfolobus solfataricus previously well characterized in our laboratory for ...
Anna La Teana,, Benelli, Dario, Giuseppe, Perugino, LO GULLO, Giada, Londei, Paola, Rosanna, Mattossovich   +5 more
core   +2 more sources

Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in EnvironmentalAeromonasspp. [PDF]

, 2008
Vincent Cattoir, Laurent Poirel, Camille Aubert, Claude–James Soussy, Patrice Nordmann   +4 more
openalex   +1 more source