Results 91 to 100 of about 1,471,930 (290)
DNA vaccines for viral diseases
Brazilian Journal of Medical and Biological Research, 1999 DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization.
J.J. Donnelly, J.B. Ulmer
doaj +1 more source
Plasmid interference for curing antibiotic resistance plasmids in vivo [PDF]
PLOS ONE, 2017 Antibiotic resistance increases the likelihood of death from infection by common pathogens such as Escherichia coli and Klebsiella pneumoniae in developed and developing countries alike. Most important modern antibiotic resistance genes spread between such species on self-transmissible (conjugative) plasmids. These plasmids are traditionally grouped on
M. Kamruzzaman +6 more
openaire +4 more sources
A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition
Frontiers in Microbiology, 2020 Toxin/antitoxin (TA) systems are present in most prokaryote genomes. Toxins are almost exclusively proteins that reduce metabolism (but do not cause cell death), and antitoxins are either RNA or proteins that counteract the toxin or the RNA that encodes ...
Sooyeon Song, Thomas K. Wood
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Plasmid copy number underlies adaptive mutability in bacteria. [PDF]
, 2014 The origin of mutations under selection has been intensively studied using the Cairns-Foster system, in which cells of an Escherichia coli lac mutant are plated on lactose and give rise to 100 Lac+ revertants over several days. These revertants have been
Aboubechara, John Paul +4 more
core +1 more source
Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals
mBio, 2014 How sublethal levels of antibiotics and heavy metals select for clinically important multidrug resistance plasmids is largely unknown. Carriage of plasmids generally confers substantial fitness costs, implying that for the plasmid-carrying bacteria to be
E. Gullberg +4 more
semanticscholar +1 more source
Frontiers in Microbiology, 2020 ObjectiveThe aims of this study were to describe azithromycin (AZM) susceptibility patterns among Shigella isolates in Anhui, China and identify predictors of resistance with mobile element-mediated genes.MethodsA total of 517 non-duplicate Shigella ...
Yanyan Liu +16 more
doaj +1 more source
The analysis of plasmid rearrangements observed in the soil bacterium OR168 after the introduction of transposon Tn5 : a thesis presented in fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University [PDF]
, 1994 Transposon Tn5 mutagenesis has been used extensively in Escherichia coli and various other Gram-negative bacteria to produce both random and site directed mutants.
Harte, David John Gerard
core
Frontiers in Microbiology, 2015 Plasmids operate as independent genetic elements in microorganism communities. Through horizontal gene transfer (HGT), they can provide their host microorganisms with important functions such as antibiotic resistance and heavy metal resistance.
An-dong Li, Li-Guan Li, Tong Zhang
semanticscholar +1 more source
Bacteriophages limit the existence conditions for conjugative plasmids [PDF]
, 2015 Bacteriophages are a major cause of bacterial mortality and impose strong selection on natural bacterial populations, yet their effects on the dynamics of conjugative plasmids have rarely been tested.
Brockhurst, Michael A. +7 more
core +5 more sources