Results 231 to 240 of about 1,502,313 (400)

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

open access: yesAdvanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham   +9 more
wiley   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

open access: yesAdvanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson   +12 more
wiley   +1 more source

Comprehensive genomic analysis of antibiotic resistance plasmids in animal-associated <i>Staphylococcus aureus</i> in France. [PDF]

open access: yesMicrobiol Spectr
Contarin R   +6 more
europepmc   +1 more source

A Sustainable Biotechnology Approach for Mineral Separation

open access: yesAdvanced Functional Materials, EarlyView.
Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang   +7 more
wiley   +1 more source

DNA-mediated UCP1 overexpression in adipose tissue: A promising anti-obesity gene therapy. [PDF]

open access: yesClin Transl Med
Zhao ZW   +10 more
europepmc   +1 more source

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2015
Chung-Te Lee   +15 more
semanticscholar   +1 more source

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