Results 251 to 260 of about 1,300,884 (312)

Linear representations of circular plasmids observed in USA300-HOU-MR (a, b) and USA300-MS (c)

, 2011
K Highlander Sarah, G Hultén Kristina, Xiang Qin, Jiang Huai-yang, Shailaja Yerrapragada, O Mason Edward, Yue Shang, M Williams Tiffany, M Fortunov Régine, Yamei Liu, Igboeli Okezie, Petrosino Joseph, Tirumalai Madhan, Akif Uzman, EA George, Cardenas Ana Maria, M Muzny Donna, Hemphill Lisa, Dashen Yan, Dugan Shannon, Rózsa Péter, J Buhay Christian, H Dinh Huyen, C Hawes Alicia, Holder Michael, L Kovar Christie, L Lee Sandra, Wen Liu, V Nazareth Lynne, Qiaoyan Wang, Zhou Jianling, Lorraine Sheldon, M Weinstock George   +32 more
openalex   +1 more source

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Unravelling the genomic landscape of Canadian <i>Borrelia burgdorferi</i>: a comparison across global strains. [PDF]

Microb Genom
Piot A, Mainprize IL, Wood J, Gauthier J, Khursigara CM, Thivierge K, Wills MKB, Levesque RC.   +7 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Robust Functionality and Regulation of Selectively Expressed RNA as AAV Vectors and In Vitro Transcribed Molecules. [PDF]

Pharmaceutics
Rastfeld F, Hersch N, Dreissen G, Manoharan H, Wagner L, Lövenich L, Barczak E, Büning H, Merkel R, Hoffmann B.   +9 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Giant linear plasmids in Mycobacterium avium harbour a tRNA array unit. [PDF]

DNA Res
Yano H, Arikawa K, Ikeda H, Nonoyama S, Maruyama F, Kitada S, Kida H, Ato M, Iwamoto T, Nishiuchi Y.   +9 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Molecular characterization of a clinical ST145 <i>Klebsiella oxytoca</i> strain co-producing KPC-2 and IMP-96 carbapenemases. [PDF]

mSystems
Liu H, Yan C, Wang S, Jiang J, Jiao M, Hu F, Xu X.   +6 more
europepmc   +1 more source