Results 271 to 280 of about 1,085,040 (311)

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Genetic exchange networks bridge mobile DNA vehicles in the bacterial pathogen Listeria monocytogenes. [PDF]

Nat Commun
Muller H, Ikhimiukor OO, Montoya-Giraldo M, Piper KR, Marmion M, Blumerman SL, Mingle L, Wirth SE, Musser KA, Wolfgang WJ, Andam CP.   +10 more
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Genomic characterization of <i>Vibrio parahaemolyticus</i> strain (AG1) causing translucent post-larvae disease in <i>Penaeus vannamei</i>. [PDF]

Microb Genom
Mai HN, Dinh-Hung N, Pantoja Morales C, Matthews M, Wright H, Dhar AK.   +5 more
europepmc   +1 more source

Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter. [PDF]

J Extracell Vesicles
Zhao M, He M, Lin X, Wu K, Yang F, Chen X, Li H, Wang H, Tang Y.   +8 more
europepmc   +1 more source

Mechanistic insights into the formation and spread of carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> via an IncHI1B/repB hybrid virulence plasmid. [PDF]

Microb Genom
Huo B, Liu Y, Fan L, Xu L, Yang W, Wei D, Liu P, Huang S, Hong H, Liu Y.   +9 more
europepmc   +1 more source

Unraveling Plasmid Contributions to Phosphorus Acquisition in Soil Microbiomes

Bruna P, Barra PJ, García M, Liachko I, Mora MdlL, Dutilh BE, Abanto M.   +6 more
europepmc   +1 more source

Subnuclear organization and mislocalization of plasmids reduce transgene expression. [PDF]

Mol Ther Nucleic Acids
Gu N, Baliga UK, Porter JJ, Lueck JD, Dean DA.   +4 more
europepmc   +1 more source

Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity. [PDF]

Pathogens
Domingues CPF, Rebelo JS, Dionisio F, Nogueira T.   +3 more
europepmc   +1 more source