Results 291 to 300 of about 1,390,499 (412)

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Icariside II induces ferroptosis through the down-regulation of SLC7A11 in ovarian cancer. [PDF]

J Ovarian Res
Yuan D, Guo T, Zhu X, Song W, Nie D, Yu H.   +5 more
europepmc   +1 more source

Clonal distribution of resistance plasmid-carryingSalmonella typhimurium, mainly in the Middle East [PDF]

, 1977
E. S. Anderson, E. J. Threlfall, Jacqueline M. Carr, Moyra M. McConnell, Henry R. Smith   +4 more
openalex   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Genomic insights into the plasmidome of non-tuberculous mycobacteria. [PDF]

Genome Med
Diricks M, Maurer FP, Dreyer V, Barilar I, Utpatel C, Merker M, Wetzstein N, Niemann S.   +7 more
europepmc   +1 more source

Isolation and characterization of four plasmids from Bacillus subtilis [PDF]

, 1977
Toshihiro Tanaka, Masamichi Kuroda, Kenji Sakaguchi   +2 more
openalex   +1 more source

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation

Advanced Science, EarlyView.
This article studies the role of UFMylation in NLRP3 inflammasome activation. It reveals that UFMylation, mediated by the E3 Ufm1‐ligase 1 (Ufl1), maintains NLRP3 stability by preventing its ubiquitination and subsequent autophagic degradation.
Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen   +14 more
wiley   +1 more source

Plasmid conjugation drives within-patient plasmid diversity. [PDF]

Microb Genom
Grayson F, Loman L, Nonnenmacher T, Pople D, Pollard J, Patel B, Williams D, Hounsome L, Hopkins KL, Robotham JV, Ledda A.   +10 more
europepmc   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei, Jian Zhao, Jin Hou, Shi Hu   +8 more
wiley   +1 more source

Heterologous Biosynthesis of Prenylflavonoids in <i>Escherichia coli</i> Based on Fungus Screening of Prenyltransferases. [PDF]

ACS Omega
Fan Z, Wang Y, Ning T, Chen J, Zhou Z, Liu Z, Wang P, Yan X.   +7 more
europepmc   +1 more source