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Antibiotic resistance begets more resistance: chromosomal resistance mutations mitigate fitness costs conferred by multi-resistant clinical plasmids

Microbiology Spectrum
Plasmids are the primary vectors of horizontal transfer of antibiotic resistance genes among bacteria. Previous studies have shown that the spread and maintenance of plasmids among bacterial populations depend on the genetic makeup of both the plasmid ...
Ramith R. Nair, Dan I. Andersson, Omar M. Warsi   +2 more
doaj   +2 more sources

Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria

Antibiotics, 2021
Antimicrobial resistance is a global public health concern, and resistance genes in Salmonella, especially those located on mobile genetic elements, are part of the problem.
Abdurrahman Hassan Jibril, Iruka N. Okeke, Anders Dalsgaard, Vanesa García Menéndez, John Elmerdahl Olsen   +4 more
doaj   +1 more source

Implication of different replicons in the spread of the VIM-1-encoding integron, In110, in Enterobacterales from Czech hospitals

Frontiers in Microbiology, 2023
BackgroundVIM metallo-β-lactamases are enzymes characterized by the ability to hydrolyze all β-lactams. Usually, blaVIM-like genes are carried by class 1 integrons.
Ibrahim Bitar, Ibrahim Bitar, Costas C. Papagiannitsis, Lucie Kraftova, Lucie Kraftova, Vittoria Mattioni Marchetti, Vittoria Mattioni Marchetti, Efthymia Petinaki, Marc Finianos, Marc Finianos, Katerina Chudejova, Katerina Chudejova, Helena Zemlickova, Helena Zemlickova, Jaroslav Hrabak, Jaroslav Hrabak   +15 more
doaj   +1 more source

A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids

Micromachines, 2021
Optical DNA mapping (ODM) has developed into an important technique for DNA analysis, where single DNA molecules are sequence-specifically labeled and stretched, for example, in nanofluidic channels.
Sriram KK, Yii-Lih Lin, Tsegaye Sewunet, Marie Wrande, Linus Sandegren, Christian G. Giske, Fredrik Westerlund   +6 more
doaj   +1 more source

Dissection of Highly Prevalent qnrS1-Carrying IncX Plasmid Types in Commensal Escherichia coli from German Food and Livestock

Antibiotics, 2021
Plasmids are mobile genetic elements, contributing to the spread of resistance determinants by horizontal gene transfer. Plasmid-mediated quinolone resistances (PMQRs) are important determinants able to decrease the antimicrobial susceptibility of ...
Katharina Juraschek, Annemarie Käsbohrer, Burkhard Malorny, Stefan Schwarz, Diana Meemken, Jens André Hammerl   +5 more
doaj   +1 more source

Mobility of Plasmids [PDF]

Microbiology and Molecular Biology Reviews, 2010
SUMMARYPlasmids are key vectors of horizontal gene transfer and essential genetic engineering tools. They code for genes involved in many aspects of microbial biology, including detoxication, virulence, ecological interactions, and antibiotic resistance.
Smillie, C., Garcillan-Barcia, M. P., Francia, M. V., Rocha, Eduardo, de La Cruz, F.   +4 more
openaire   +4 more sources

The type I-E CRISPR-Cas system influences the acquisition of blaKPC-IncF plasmid in Klebsiella pneumonia

Emerging Microbes and Infections, 2020
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258
Ying Zhou, Yu Tang, Pan Fu, Dongxing Tian, Lianhua Yu, Yunkun Huang, Gang Li, Meng Li, Yong Wang, Zehua Yang, Xiaogang Xu, Zhe Yin, Dongsheng Zhou, Laurent Poirel, Xiaofei Jiang   +14 more
doaj   +1 more source

Characterizing Plasmids in Bacteria Species Relevant to Urinary Health

Microbiology Spectrum, 2021
The urinary tract has a microbial community (the urinary microbiota or urobiota) that has been associated with human health. Whole genome sequencing of bacteria is a powerful tool, allowing investigation of the genomic content of the urobiota, also ...
Cesar Montelongo Hernandez, Catherine Putonti, Alan J. Wolfe   +2 more
doaj   +1 more source

PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli

mBio, 2022
The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide.
Lingxian Yi, Romain Durand, Frédéric Grenier, Jun Yang, Kaiyang Yu, Vincent Burrus, Jian-Hua Liu   +6 more
doaj   +1 more source

Cloning vectors for gene delivery, integration and expression in Campylobacter jejuni

BioTechniques, 2022
Campylobacter genetics research is negatively impacted by a shortage of molecular tools for expressing DNA elements. A previous technique coupled an antibiotic resistance gene and its promoter to a gene of interest, inserting this expression unit into a ...
Gaylen A Uhlich, Lori Bagi, Nereus W Gunther   +2 more
doaj   +1 more source