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Characterization of Four Multidrug Resistance Plasmids Captured from the Sediments of an Urban Coastal Wetland

Frontiers in Microbiology, 2017
Self-transmissible and mobilizable plasmids contribute to the emergence and spread of multidrug-resistant bacteria by enabling the horizontal transfer of acquired antibiotic resistance.
Celeste J Brown, Eva M Top
exaly   +3 more sources

Diverse Fluoroquinolone Resistance Plasmids From Retail Meat E. coli in the United States

Frontiers in Microbiology, 2019
Fluoroquinolones are used to treat serious bacterial infections, including those caused by Escherichia coli and Salmonella enterica. The emergence of plasmid-mediated quinolone resistance (PMQR) represent a new challenge to the successful treatment of ...
Gregory H Tyson, Patrick F Mcdermott
exaly   +3 more sources

Genomic Characterization of a Uropathogenic Escherichia coli ST405 Isolate Harboring blaCTX-M-15-Encoding IncFIA-FIB Plasmid, blaCTX-M-24-Encoding IncI1 Plasmid, and Phage-Like Plasmid

Frontiers in Microbiology, 2022
Escherichia coli sequence type 405 is an emerging antibiotic-resistant clonal group associated with the global dissemination of extended-spectrum β-lactamase-producing E. coli.
Mianzhi Yao, Qianhui Zhu, Qianhui Zhu, Jin Zou, Abebe Mekuria Shenkutie, Abebe Mekuria Shenkutie, Songnian Hu, Songnian Hu, Jiuxin Qu, Zilong He, Zilong He, Polly H. M. Leung   +11 more
doaj   +1 more source

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

eLife, 2021
Many plasmids encode antibiotic resistance genes. Through conjugation, plasmids can be rapidly disseminated. Previous work identified gut luminal donor/recipient blooms and tissue-lodged plasmid-bearing persister cells of the enteric pathogen Salmonella ...
Erik Bakkeren, Joana Anuschka Herter, Jana Sanne Huisman, Yves Steiger, Ersin Gül, Joshua Patrick Mark Newson, Alexander Oliver Brachmann, Jörn Piel, Roland Regoes, Sebastian Bonhoeffer, Médéric Diard, Wolf-Dietrich Hardt   +11 more
doaj   +1 more source

PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli

mBio, 2022
The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide.
Lingxian Yi, Romain Durand, Frédéric Grenier, Jun Yang, Kaiyang Yu, Vincent Burrus, Jian-Hua Liu   +6 more
doaj   +1 more source

Nanopore MinION Sequencing Reveals Possible Transfer of blaKPC–2 Plasmid Across Bacterial Species in Two Healthcare Facilities

Frontiers in Microbiology, 2020
Carbapenemase-producing Enterobacteriaceae are a major threat to global public health. Klebsiella pneumoniae carbapenemase (KPC) is the most commonly identified carbapenemase in the United States and is frequently found on mobile genetic elements ...
Catharine Prussing, Emily A. Snavely, Navjot Singh, Pascal Lapierre, Erica Lasek-Nesselquist, Kara Mitchell, Wolfgang Haas, Rita Owsiak, Elizabeth Nazarian, Kimberlee A. Musser   +9 more
doaj   +1 more source

Pan-Genome Portrait of Bacillus mycoides Provides Insights into the Species Ecology and Evolution

Microbiology Spectrum, 2021
Bacillus mycoides is poorly known despite its frequent occurrence in a wide variety of environments. To provide direct insight into its ecology and evolutionary history, a comparative investigation of the species pan-genome and the functional gene ...
Krzysztof Fiedoruk, Justyna M. Drewnowska, Jacques Mahillon, Monika Zambrzycka, Izabela Swiecicka   +4 more
doaj   +1 more source

Characterizing Plasmids in Bacteria Species Relevant to Urinary Health

Microbiology Spectrum, 2021
The urinary tract has a microbial community (the urinary microbiota or urobiota) that has been associated with human health. Whole genome sequencing of bacteria is a powerful tool, allowing investigation of the genomic content of the urobiota, also ...
Cesar Montelongo Hernandez, Catherine Putonti, Alan J. Wolfe   +2 more
doaj   +1 more source

The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental Factors and Gene Interactions via Mobile Genetic Elements

Frontiers in Microbiology, 2021
Of the seven currently known botulinum neurotoxin-producing species of Clostridium, C. parabotulinum, or C. botulinum Group I, is the species associated with the majority of human botulism cases worldwide.
Theresa J. Smith, Charles H. D. Williamson, Karen K. Hill, Shannon L. Johnson, Gary Xie, Fabrizio Anniballi, Bruna Auricchio, Rafael A. Fernández, Patricia A. Caballero, Paul Keim, Jason W. Sahl   +10 more
doaj   +1 more source

The Hypercomplex Genome of an Insect Reproductive Parasite Highlights the Importance of Lateral Gene Transfer in Symbiont Biology

mBio, 2020
Mobile elements—plasmids and phages—are important components of microbial function and evolution via traits that they encode and their capacity to shuttle genetic material between species. We here report the unusually rich array of mobile elements within
Crystal L. Frost, Stefanos Siozios, Pol Nadal-Jimenez, Michael A. Brockhurst, Kayla C. King, Alistair C. Darby, Gregory D. D. Hurst   +6 more
doaj   +1 more source