Results 191 to 200 of about 317,079 (354)
9‐Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.ABSTRACT
The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).Bruno Antonio Ferreira, Isabella Silva Cassimiro, Francyelle Borges Rosa de Moura, Tais de Campos Lima, Danielle Reis Napolitano, Eric Umehara, João Henrique Ghilardi Lago, Fernanda de Assis Araújo +7 morewiley +1 more sourceSplenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture. [PDF]
PLoS Negl Trop DisBenabdelmoumen G, Itani O, Joste V, Houzé S, Hardy D, Bavozet F, Sylla M, Kho S, Anstey NM, Consigny PH, Sissoko A, Buffet P. +11 moreeuropepmc +1 more sourceSynthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi
ChemMedChem, Volume 21, Issue 1, January 2026.Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão +11 morewiley +1 more sourceRapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research
, 2019 Franziska Mohring, Melissa N. Hart, Thomas A. Rawlinson, Ryan C. Henrici, James Charleston, Ernest Diez Benavente, Avnish Patel, Joanna Hall, Neil Almond, Susana Campino, Taane G. Clark, Colin J. Sutherland, David A. Baker, Simon J. Draper, Robert W. Moon +14 moreopenalex +1 more sourceSelection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia
, 2021 Jessica T. Lin, Andreea Waltmann, Kara A. Moser, Zackary Park, Yu Bin Na, Özkan Aydemir, Nicholas F. Brazeau, Panita Gosi, Patrick W. Marsh, Meredith Muller, Michele Spring, Somethy Sok, Jeffrey A. Bailey, David Saunders, Chanthap Lon, Mariusz Wojnarski +15 moreopenalex +2 more sourcesExploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter
ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs +14 morewiley +1 more sourceIn vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations
, 2019 Jie Zhang, Na Li, Faiza Amber Siddiqui, Shiling Xu, Jinting Geng, Jiaqi Zhang, Xi He, Luyi Zhao, Liang Pi, Yanmei Zhang, Cuiying Li, Xi Chen, Yanrui Wu, Jun Miao, Yaming Cao, Liwang Cui, Zhaoqing Yang +16 moreopenalex +1 more source
