Results 1 to 10 of about 287,184 (330)

Plasmodium falciparum biosynthesizes sulfoglycosphingolipids

Molecular and Biochemical Parasitology, 2007
Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to be involved in the regulation of cell proliferation, differentiation and other developmental cellular events.
Landoni, Malena, Duschak, Vilma Gladys, Peres, Valnice J., Nonami, Hiroshi, Erra Balsells, Rosa, Katzin, Alejandro M., Couto, Alicia Susana   +6 more
openaire   +4 more sources

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission [PDF]

, 2009
1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp.
A Meister, A Molina-Cruz, Adelfa E. Serrano, AF Cowman, Andrew P. Waters, B Franke-Fayard, B Mons, Blandine Franke-Fayard, C Birago, C Birago, Chris J. Janse, CJ Janse, CJ Janse, Daniel Eliot Goldberg, DF Platel, DL Doolan, E Liebau, F Quittnat, H Atamna, H Sies, H Sztajer, H Tsutsui, Isabelle Coppens, J Krungkrai, J Liu, JF Rodriguez, JF Turrens, Joel Vega-Rodríguez, José F. Rodríguez-Orengo, K Ayi, K Becker, K Becker, K Becker, K Buchholz, K Komaki-Yasuda, K Lüersen, K Lüersen, K Yano, KG Sharma, L Tilley, LH Lash, M Arai, MA Mansoor, Marcelo Jacobs-Lorena, N Hall, N Tirawanchai, P Harwaldt, P Srinivasan, RE Sinden, Rebecca Pastrana-Mena, Rhoel R. Dinglasan, RL Krauth-Siegel, RM van Spaendonk, RR Dinglasan, S Kumar, S Meierjohann, S Meierjohann, S Müller, S Müller, SM Kanzok, T Russo, T Vernoux, TM Peterson, TT Huynh, V Enea, VC Baggaley, Y Dong, YR Sailaja   +67 more
core   +8 more sources

Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria. [PDF]

, 2009
BACKGROUND: Studies to identify phenotypically-associated polymorphisms in the Plasmodium falciparum 23 Mb genome will require a dense array of marker loci.
Chokejindachai, Watcharee, Conway, David J   +1 more
core   +7 more sources

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi [PDF]

, 2011
<b>Background:</b> Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P.
Alex McConnachie, Allan Macheso, B Haubold, BS Weir, C Roper, CJ Sutherland, DJ Conway, E Kosman, FE McKenzie, HM Gilles, J Goudet, J May, JM Vinetz, K Maitland, K Mugittu, L Henning, LH Taylor, M Tanner, Malcolm E Molyneux, Marian C Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MU Ferreira, N Fraser-Hurt, N Tanomsing, PCC Garnham, R Tahar, RD Page, RL Ord, S Enosse, S Nair, S Zakeri, T Smith, T Smith, T Smith, T Smith, The Ministry of Health and Population, TJ Anderson, TJC Anderson, TL Ritchie, WE Collins, WJ Collins   +44 more
core   +4 more sources

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +2 more sources

Gametocytogenesis: the puberty of Plasmodium falciparum.

Malaria journal, 2004
The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P.
Arthur M. Talman, Arthur M. Talman, F. Ellis McKenzie, Frédéric Ariey, Olivier Domarle, Vincent Robert, Vincent Robert   +6 more
openaire   +4 more sources

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]

, 2011
Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Bourdoncle, P., Chandran, S., Dandavate, V., Langsley, G., Meissner, M., Ndjembo-Ezougou, C., Rached, F.B., Talabani, H., Tatu, U., Yera, H.   +9 more
core   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +2 more sources

Whole genome sequencing and microsatellite analysis of the Plasmodium falciparum E5 NF54 strain show that the var, rifin and stevor gene families follow Mendelian inheritance [PDF]

, 2018
Background: Plasmodium falciparum exhibits a high degree of inter-isolate genetic diversity in its variant surface antigen (VSA) families: P. falciparum erythrocyte membrane protein 1, repetitive interspersed family (RIFIN) and subtelomeric variable ...
Bruske, Ellen, Frank, Matthias, Otto, Thomas D.   +2 more
core   +5 more sources