Results 1 to 10 of about 189,534 (218)

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

Nature Microbiology, 2023
Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination efforts; hence we need to monitor emergence, evolution and spread of drug- and diagnostics-resistant ...
A. Fola, S. Feleke, H. Mohammed, B. G. Brhane, C. Hennelly, A. Assefa, Rebecca M Crudal, E. Reichert, J. Juliano, J. Cunningham, H. Mamo, H. Solomon, G. Tasew, B. Petros, J. Parr, J. Bailey   +15 more
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Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Network Boston, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, Jean-Louis Mangala Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
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Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.

Annual Review of Microbiology, 2020
Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant to chloroquine, amodiaquine, or piperaquine harbor mutations in the P ...
Kathryn J. Wicht, Sachel Mok, D. Fidock
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The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

Nature, 2015
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital to inform future control planning.
S. Bhatt, D. Weiss, E. Cameron, D. Bisanzio, B. Mappin, U. Dalrymple, K. Battle, C. Moyes, Andrew J. Henry, P. Eckhoff, E. Wenger, O. Briët, O. Briët, M. Penny, M. Penny, T. Smith, T. Smith, A. Bennett, J. Yukich, T. Eisele, J. Griffin, C. Fergus, Michael Lynch, F. Lindgren, Justin M. Cohen, C. Murray, Dave L. Smith, Simon Iain Hay, Simon Iain Hay, Simon Iain Hay, R. Cibulskis, P. Gething   +31 more
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Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

Nature, 2019
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective ...
Jonathan Kim, Yong Zi Tan, Kathryn J. Wicht, S. Erramilli, Satish K. Dhingra, John Okombo, Jérémie Vendôme, Laura M. Hagenah, Sabrina Giacometti, Audrey L. Warren, K. Nosol, P. Roepe, C. Potter, B. Carragher, A. Kossiakoff, M. Quick, D. Fidock, F. Mancia   +17 more
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Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Science, 2019
Ebb and flow of parasite populations The population genetics of the malaria parasite Plasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power
A. Amambua-Ngwa, L. Amenga-Etego, E. Kamau, R. Amato, A. Ghansah, L. Golassa, M. Randrianarivelojosia, D. Ishengoma, T. Apinjoh, O. Maïga-Ascofaré, B. Andagalu, W. Yavo, M. Bouyou-Akotet, O. Kolapo, Karim Mane, A. Worwui, D. Jeffries, Vikki Simpson, U. d’Alessandro, D. Kwiatkowski, A. Djimde   +20 more
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Persistent transmission of Plasmodium malariae and Plasmodium ovale species in an area of declining Plasmodium falciparum transmission in eastern Tanzania

PLoS Neglected Tropical Diseases, 2019
A reduction in the global burden of malaria over the past two decades has encouraged efforts for regional malaria elimination. Despite the need to target all Plasmodium species, current focus is mainly directed towards Plasmodium falciparum, and to a ...
Victor Yman, Grace M Wandell, Doreen D Mutemi, Aurelie Miglar, M. Asghar, U. Hammar, Mattias Karlsson, Ingrid Lind, Cleis Nordfjell, I. Rooth, B. Ngasala, M. V. Homann, A. Färnert   +12 more
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Nature Communications, 2018
The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the Plasmodium falciparum ...
Leila S Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, B. Witkowski, R. Fairhurst, F. Ariey, D. Ménard, D. Fidock   +11 more
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Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

Immunological Reviews, 2019
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja T. R. Jensen, Yvonne Adams, L. Hviid   +2 more
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Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

Science Translational Medicine, 2019
Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum. Development of a new antimalarial drug Pantothenenic acid, or vitamin B5, is an essential nutrient for the deadly malaria ...
J. Schalkwijk, Erik L. Allman, P. Jansen, Laura E. de Vries, Julie M. J. Verhoef, S. Jackowski, Peter N. M. Botman, Christien A. Beuckens-Schortinghuis, Karin M. J. Koolen, J. Bolscher, Martijn W. Vos, K. Miller, Stacy A. Reeves, Helmi E Pett, G. Trevitt, S. Wittlin, C. Scheurer, Sibylle Sax, Christoph Fischli, Iñigo Angulo-Barturen, M. Jiménez-Díaz, G. Josling, T. Kooij, Roger Bonnert, B. Campo, R. Blaauw, F. Rutjes, R. Sauerwein, M. Llinás, P. Hermkens, K. Dechering   +30 more
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