Results 1 to 10 of about 187,469 (163)

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

New England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
Arjen Dondorp, Phaik Yeong Cheah, Ye Htut   +2 more
exaly   +2 more sources

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum

Cell, 2017
Summary Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes,
Deepali Ravel, Ana Conejo-García, Mariana De Niz   +2 more
exaly   +2 more sources

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

New England Journal of Medicine, 2016
BACKGROUND Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P.
David A. Fidock, Din Syafruddin, Ines Vigan-Womas   +2 more
exaly   +2 more sources

Serum anti-erythropoietin antibodies among pregnant women with Plasmodium falciparum malaria and anaemia: A case-control study in northern Ghana

PLoS ONE, 2023
Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum ...
Charles Nkansah, Simon Bannison Bani, Kofi Mensah, Samuel Kwasi Appiah, Felix Osei-Boakye, Gabriel Abbam, Samira Daud, Eugene Mensah Agyare, Peace Esenam Agbadza, Charles Angnataa Derigubah, Dorcas Serwaa, Francis Atoroba Apodola, Yeduah Quansah, Rahama Issah, Samuel Yennuloom Dindiok, Felix Ejike Chukwurah   +15 more
doaj   +2 more sources

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

Nature Microbiology, 2023
Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination efforts; hence we need to monitor emergence, evolution and spread of drug- and diagnostics-resistant ...
A. Fola, S. Feleke, H. Mohammed, B. Brhane, C. Hennelly, A. Assefa, Rebecca M Crudal, E. Reichert, J. Juliano, J. Cunningham, H. Mamo, H. Solomon, G. Tasew, B. Petros, J. Parr, J. Bailey   +15 more
semanticscholar   +1 more source

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

New England Journal of Medicine, 2017
Jun Cao, Richard Culleton, Abhinay Ramaprasad   +2 more
exaly   +2 more sources

Plasmodium falciparum resistance to artemisinin-based combination therapies

Current Opinion in Microbiology, 2022
Multidrug-resistant Plasmodium falciparum parasites are a major threat to public health in intertropical regions. Understanding the mechanistic basis, origins, and spread of resistance can inform strategies to mitigate its impact and reduce the global ...
Kurt E. Ward, D. Fidock, Jessica L. Bridgford   +2 more
semanticscholar   +1 more source

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda

Malaria Journal, 2021
Background Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.
Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke, Teun Bousema   +6 more
doaj   +1 more source

Evaluation of a novel real-time PCR assay for the detection, identification and quantification of Plasmodium species causing malaria in humans

Malaria Journal, 2021
Background The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections.
Kim van Bergen, Toon Stuitje, Robert Akkers, Eric Vermeer, Rob Castel, Theo Mank   +5 more
doaj   +1 more source

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Medicine, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, J. Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
semanticscholar   +1 more source