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Plasmodium falciparum

Trends in Parasitology, 2019
Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death due to a vector-borne infectious disease, claiming 0.5 million lives every year. The single-cell eukaryote undergoes a complex life cycle and is an obligate intracellular parasite of hepatocytes (clinically silent) and erythrocytes (disease causing).
Maier, Alex, Matuschewski, Kai, Zhang, Meng, Rug, Melanie   +3 more
semanticscholar   +6 more sources

Serum anti-erythropoietin antibodies among pregnant women with Plasmodium falciparum malaria and anaemia: A case-control study in northern Ghana

PLoS ONE, 2023
Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum ...
Charles Nkansah, Simon Bannison Bani, Kofi Mensah, Samuel Kwasi Appiah, Felix Osei-Boakye, Gabriel Abbam, Samira Daud, Eugene Mensah Agyare, Peace Esenam Agbadza, Charles Angnataa Derigubah, Dorcas Serwaa, Francis Atoroba Apodola, Yeduah Quansah, Rahama Issah, Samuel Yennuloom Dindiok, Felix Ejike Chukwurah   +15 more
doaj   +2 more sources

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +28 more sources

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda

Malaria Journal, 2021
Background Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.
Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke, Teun Bousema   +6 more
doaj   +1 more source

Evaluation of a novel real-time PCR assay for the detection, identification and quantification of Plasmodium species causing malaria in humans

Malaria Journal, 2021
Background The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections.
Kim van Bergen, Toon Stuitje, Robert Akkers, Eric Vermeer, Rob Castel, Theo Mank   +5 more
doaj   +1 more source

Cessation of mass drug administration for lymphatic filariasis in Zanzibar in 2006: was transmission interrupted? [PDF]

, 2015
BACKGROUND: Lymphatic filariasis (LF) is targeted for elimination through annual mass drug administration (MDA) for 4-6 years. In 2006, Zanzibar stopped MDA against LF after five rounds of MDA revealed no microfilaraemic individuals during surveys at ...
Cullen, Katelyn J, Desai, Monica, Harris, Ross J, Hope, Vivian D, Ijaz, Samreen, Mandal, Sema, Ncube, Fortune, Parry, John V, Platt, Lucy, Shute, Justin, Vickerman, Peter   +10 more
core   +11 more sources

Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]

, 2009
Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
A Witkowski, BJ Foth, BP Mooney, BS Crabb, C Lambros, C Wrenger, CJ Janse, CJ Tonkin, J Mazumdar, J Sambrook, J Umlas, JE Cronan, JL Stephens, Kai Matuschewski, KG Le Roch, KM Keeney, Lisa F. P. Ng, LJ Reed, M Allary, M O'Riordan, MB Reed, MJ Crawford, MM Bradford, N Thomsen-Zieger, PJ McMillan, R Douce, R Yasuno, RN Perham, S Günther, S Günther, S Günther, Svenja Günther, Sylke Müller, V Gueguen, V Thathy, W Trager, Y Wu, Y Wu   +37 more
core   +17 more sources

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

Malaria Journal, 2020
Background Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic ...
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich, Thierry Rolling   +5 more
doaj   +1 more source

Potensi vaksinasi P. Falciparum circumsporozoite protein adjuvan CAF09 (PF CSP-CAF09) untuk pencegahan malaria dengan induksi sel t CD8+

JKS (Jurnal Kedokteran Syiah Kuala), 2023
Malaria masih merupakan ancaman yang serius karena dapat menyerang siapa saja tanpa sistem imunitas yang adekuat dan dapat menyebar dengan cepat melalui vektornya.
Fandy Ong Jaya, Sugiono Namli, Melly Leman, Restuti Hidayani Saragih   +3 more
doaj   +1 more source

Genomic epidemiology of artemisinin resistant malaria

eLife, 2016
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations.
MalariaGEN Plasmodium falciparum Community Project
doaj   +1 more source