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Trends in Parasitology, 2019 Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death due to a vector-borne infectious disease, claiming 0.5 million lives every year. The single-cell eukaryote undergoes a complex life cycle and is an obligate intracellular parasite of hepatocytes (clinically silent) and erythrocytes (disease causing).
A. Maier +3 more
semanticscholar +4 more sources
PLoS ONE, 2023 Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum ...
Charles Nkansah +15 more
doaj +2 more sources
Protein Sorting in Plasmodium Falciparum [PDF]
Life, 2021 Plasmodium falciparum is a unicellular eukaryote with a very polarized secretory system composed of micronemes rhoptries and dense granules that are required for host cell invasion. P. falciparum, like its relative T. gondii, uses the endolysosomal system to produce the secretory organelles and to ingest host cell proteins.
openaire +4 more sources
Artemisinin resistance in Plasmodium falciparum [PDF]
The Lancet Infectious Diseases, 2014 Benoit Witkowski and colleagues reported a simple and rapid in vitro method to detect artemisinin resistance of P falciparum. They show that the slow clearance of parasites by artemisinin combination therapies is a result of a drop in susceptibility among young ring form parasites whereas susceptibility is maintained in mature stages.
Lun, Zhao-Rong +2 more
openaire +8 more sources
Malaria Journal, 2021 Background Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.
Daniel Ayo +6 more
doaj +1 more source
Plasmodium falciparum and the brain [PDF]
BMC Proceedings, 2008 A unique characteristic of P. falciparum is that the infected erythrocytes sequester within the deep vascular beds, particularly those of the brain. The blood brain barrier appears to be impaired. The most common CNS manifestations are seizures, agitation, psychosis, impaired consciousness and coma (cerebral malaria), but there are differences in ...
Charles R. Newton, Charles R. Newton
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Nature Network Boston, 2020 Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana +17 more
semanticscholar +1 more source
Detectability of Plasmodium falciparum clones [PDF]
Malaria Journal, 2010 In areas of high transmission people often harbour multiple clones of Plasmodium falciparum, but even PCR-based diagnostic methods can only detect a fraction (the detectability, q) of all clones present in a host. Accurate measurements of detectability are desirable since it affects estimates of multiplicity of infection, prevalence, and frequency of ...
Bretscher, M. T. +5 more
openaire +6 more sources
Malaria Journal, 2021 Background The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections.
Kim van Bergen +5 more
doaj +1 more source
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.
Annual Review of Microbiology, 2020 Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant to chloroquine, amodiaquine, or piperaquine harbor mutations in the P ...
Kathryn J. Wicht, Sachel Mok, D. Fidock
semanticscholar +1 more source