Results 1 to 10 of about 302,576 (367)

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model [PDF]

, 2015
The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P. ovale malarias presents a major challenge for malaria control and elimination in endemic countries.
Bassat, Quique, Betuela, Inoni, Brewster, Jessica, Felger, Ingrid, Hofmann, Natalie E., Karl, Stephan, Kinboro, Benson, Kiniboro, Benson, Li Wai Suen, Connie S. N., Lorry, Lina, Mueller, Ivo, Robinson, Leanne J., Samol, Lornah, Schofield, Louis, Siba, Peter M., Silkey, Mariabeth, Tarongka, Nandao, Waltmann, Andreea, Wampfler, Rahel, White, Michael T.   +19 more
core   +17 more sources

Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae. [PDF]

PLoS ONE, 2013
The mosquito Anopheles gambiae uses its innate immune system to control bacterial and Plasmodium infection of its midgut tissue. The activation of potent IMD pathway-mediated anti-Plasmodium falciparum defenses is dependent on the presence of the midgut ...
Benjamin J Blumberg, Stefanie Trop, Suchismita Das, George Dimopoulos   +3 more
doaj   +1 more source

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Bousema, Teun, Drakeley, Chris J, Ghani, Azra C, Okell, Lucy C, Sutherland, Colin J   +4 more
core   +3 more sources

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Nature Communications, 2018
The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid increase in the prevalence of novel mutations in the Plasmodium falciparum ...
Leila S Ross, S. K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, B. Witkowski, R. Fairhurst, F. Ariey, D. Ménard, D. Fidock   +11 more
semanticscholar   +1 more source

Performance of rapid diagnostic tests for imported malaria in clinical practice: results of a national multicenter study. [PDF]

PLoS ONE, 2013
We compared the performance of four rapid diagnostic tests (RDTs) for imported malaria, and particularly Plasmodium falciparum infection, using thick and thin blood smears as the gold standard.
Sandrine Houzé, Isabelle Boutron, Anne Marmorat, Marie Dalichampt, Christophe Choquet, Isabelle Poilane, Nadine Godineau, Anne-Sophie Le Guern, Marc Thellier, Hélène Broutier, Odile Fenneteau, Pascal Millet, Stéphanie Dulucq, Véronique Hubert, Pascal Houzé, Florence Tubach, Jacques Le Bras, Sophie Matheron   +17 more
doaj   +1 more source

Submicroscopic placental infection by non-falciparum Plasmodium spp. [PDF]

PLoS Neglected Tropical Diseases, 2018
Among the Plasmodium species that infect humans, adverse effects of P. falciparum and P. vivax have been extensively studied and reported with respect to poor outcomes particularly in first time mothers and in pregnant women living in areas with unstable
Justin Y A Doritchamou, Richard A Akuffo, Azizath Moussiliou, Adrian J F Luty, Achille Massougbodji, Philippe Deloron, Nicaise G Tuikue Ndam   +6 more
doaj   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

, 2007
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Baker, David A, Fivelman, Quinton L, McRobert, Louisa, Saeed, Maha, Sharp, Sarah, Sutherland, Colin J, Swales, Claire A, Taylor, Cathy J   +7 more
core   +1 more source

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Plasmodium falciparum « toutankhamonensis » [PDF]

Bulletin de la Société de pathologie exotique, 2010
Alexandre le Grand, les empereurs Titus et Othon II, Alaric, Olivier Cromwell, les papes Gregoire V, Leon X, Sixte V, Urbain VII, Alexandre VI, Borgia, Dante Alighieri, Byron, Le Caravage, Fausto Coppi... A la liste des victimes celebres, reelles, presumees ou imaginaires du paludisme, les medias viennent d’ajouter Toutankhamon sans se poser de ...
openaire   +1 more source