Results 181 to 190 of about 296,027 (331)

Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4‐Year‐Old Patient: A Case Report in Limbe Regional Hospital, Cameroon

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Tetanus is a life‐threatening disease preventable by immunization through vaccines. In resource‐limited settings, its association with other acute infections should be managed cautiously. A 4‐year‐old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there
Christian Damien Tchuisseu Ngapjang, Christian Fotso, Ronald Gobina, Philippe Albert Lingo, Quincy‐Jones Shumbang Tchumukong, Bertold Brecht Kouam, Marc Effila, Emelinda Berinyuy Nyuydzefon, Verla Vincent Siysi   +8 more
wiley   +1 more source

Resistência in vivo do Plasmodium falciparum às 4-aminoquinoleínas e à associação sulfadoxina-pirimetamina: II - estudo de imperatriz, Maranhão, 1983-1984 [PDF]

, 1987
Afonso Dinis Costa Passos, Carlos Hiroyuki Osanai, Santiago Reyes   +2 more
openalex   +1 more source

A method for predicting enzyme substrate specificity residues using homologous sequence information

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Identifying amino acid residues that are critical for the catalytic function of enzymes is essential for elucidating reaction mechanisms, facilitating drug discovery, and advancing protein engineering. However, experimentally and computationally distinguishing residues that maintain structural integrity from those directly involved in ...
Seiya Mori, Teppei Niide, Yoshihiro Toya, Hiroshi Shimizu   +3 more
wiley   +1 more source

Climate Change Is Expected to Expand Malaria Transmission Range and Population at Risk in Papua New Guinea

GeoHealth, Volume 9, Issue 10, October 2025.
Abstract Warming temperatures are expanding the potential for malaria transmission into higher altitudes, with important implications for malaria control planning. In Papua New Guinea (PNG), malaria is widespread in lowland areas but rarely transmitted above 1,600 m.
S. Karl, E. B. Skinner, S. McEwen, J. Keven, J. Kisomb, L. J. Robinson, M. Laman   +6 more
wiley   +1 more source

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. [PDF]

, 1984
Avner Yayon, Z. Ioav Cabantchik, H. Ginsburg   +2 more
openalex   +1 more source

Micro‐Embolic Events and Their Clearing in the Brain. A Narrative Review

Acta Physiologica, Volume 241, Issue 10, October 2025.
ABSTRACT Background The cerebral circulation is continuously challenged by intravascular micrometer‐sized particles that become trapped microvascular‐emboli. These particles may include micro‐thrombi, stiffened erythrocytes, and leukocytes, while also fat particles, air, and microplastics may cause microvascular embolism. Review Scope In this narrative
Kevin Mol, Inge A. Mulder, Ed van Bavel
wiley   +1 more source

The Gates Malaria Partnership: a consortium approach to malaria research and capacity development.

, 2012
Recently, there has been a major increase in financial support for malaria control. Most of these funds have, appropriately, been spent on the tools needed for effective prevention and treatment of malaria such as insecticide-treated bed nets, indoor ...
Bhasin, Amit, Greenwood, Brian, Targett, Geoffrey   +2 more
core   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria.

New England Journal of Medicine, 2009
A. Dondorp, F. Nosten, P. Yi, D. Das, A. P. Phyo, J. Tarning, K. Lwin., F. Ariey, Warunee Hanpithakpong, Sue J Lee, P. Ringwald, K. Silamut, M. Imwong, K. Chotivanich, Pharath Lim, T. Herdman, S. An, S. Yeung, P. Singhasivanon, N. Day, N. Lindegårdh, D. Socheat, N. White   +22 more
semanticscholar   +1 more source

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Resonance Raman Spectroscopic Study of the Unusual [4Fe‐4S]2+ Cluster of IspH, the Last Enzyme of the Methylerythritol Phosphate Pathway for Terpenoid Biosynthesis

ChemBioChem, Volume 26, Issue 18, September 18, 2025.
Raman spectroscopy confirms that the apical Fe atom of the [4Fe‐4S]2+ cluster of IspH is linked to H2O molecules and that the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐en‐1‐yl diphosphate substrate and the propargyl diphosphate inhibitor lead to a change of coordination geometry. The loss of octahedral coordination of the apical Fe atom is also very likely when the
Hannah Jobelius, Philippe Chaignon, Gabriella I. Bianchino, Joanna Wandzig, Petra Hellwig, Myriam Seemann, Frederic Melin   +6 more
wiley   +1 more source