Results 11 to 20 of about 287,184 (330)

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

New England Journal of Medicine, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam, Ariey, Frederic, Chotivanich, Kesinee, Das, Debashish, Day, Nicholas PJ, Dondorp, Arjen M, Hanpithakpong, Warunee, Herdman, Trent, Imwong, Mallika, Lee, Sue J, Lim, Pharath, Lindegardh, Niklas, Lwin, Khin Maung, Nosten, François, Phyo, Aung Phae, Ringwald, Pascal, Silamut, Kamolrat, Singhasivanon, Pratap, Socheat, Duong, Tarning, Joel, White, Nicholas J, Yeung, Shunmay, Yi, Poravuth   +22 more
core   +2 more sources

Plasmodium falciparum

Trends in Parasitology, 2019
Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death due to a vector-borne infectious disease, claiming 0.5 million lives every year. The single-cell eukaryote undergoes a complex life cycle and is an obligate intracellular parasite of hepatocytes (clinically silent) and erythrocytes (disease causing).
Maier, Alex, Matuschewski, Kai, Zhang, Meng, Rug, Melanie   +3 more
openaire   +4 more sources

Serum anti-erythropoietin antibodies among pregnant women with Plasmodium falciparum malaria and anaemia: A case-control study in northern Ghana

PLoS ONE, 2023
Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum ...
Charles Nkansah, Simon Bannison Bani, Kofi Mensah, Samuel Kwasi Appiah, Felix Osei-Boakye, Gabriel Abbam, Samira Daud, Eugene Mensah Agyare, Peace Esenam Agbadza, Charles Angnataa Derigubah, Dorcas Serwaa, Francis Atoroba Apodola, Yeduah Quansah, Rahama Issah, Samuel Yennuloom Dindiok, Felix Ejike Chukwurah   +15 more
doaj   +2 more sources

Protein Sorting in Plasmodium Falciparum [PDF]

Life, 2021
Plasmodium falciparum is a unicellular eukaryote with a very polarized secretory system composed of micronemes rhoptries and dense granules that are required for host cell invasion. P. falciparum, like its relative T. gondii, uses the endolysosomal system to produce the secretory organelles and to ingest host cell proteins.
openaire   +4 more sources

Artemisinin resistance in Plasmodium falciparum [PDF]

The Lancet Infectious Diseases, 2014
Benoit Witkowski and colleagues reported a simple and rapid in vitro method to detect artemisinin resistance of P falciparum. They show that the slow clearance of parasites by artemisinin combination therapies is a result of a drop in susceptibility among young ring form parasites whereas susceptibility is maintained in mature stages.
Lun, Zhao-Rong, Ferreira, Pedro E, Fu, Lin-Chun   +2 more
openaire   +9 more sources

Detectability of Plasmodium falciparum clones [PDF]

Malaria Journal, 2010
In areas of high transmission people often harbour multiple clones of Plasmodium falciparum, but even PCR-based diagnostic methods can only detect a fraction (the detectability, q) of all clones present in a host. Accurate measurements of detectability are desirable since it affects estimates of multiplicity of infection, prevalence, and frequency of ...
Bretscher, M. T., Valsangiacomo, F., Owusu-Agyei S.,, Penny, M. A., Felger, I., Smith, T.   +5 more
openaire   +6 more sources

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda

Malaria Journal, 2021
Background Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.
Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke, Teun Bousema   +6 more
doaj   +1 more source

Plasmodium falciparum and the brain [PDF]

BMC Proceedings, 2008
A unique characteristic of P. falciparum is that the infected erythrocytes sequester within the deep vascular beds, particularly those of the brain. The blood brain barrier appears to be impaired. The most common CNS manifestations are seizures, agitation, psychosis, impaired consciousness and coma (cerebral malaria), but there are differences in ...
Charles R. Newton, Charles R. Newton
openaire   +2 more sources

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Network Boston, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, Jean-Louis Mangala Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
semanticscholar   +1 more source

Chemical genetics of Plasmodium falciparum [PDF]

Nature, 2010
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose
Guiguemde, W Armand, Shelat, Anang A, Bouck, David, Duffy, Sandra, Crowther, Gregory J, Davis, Paul H, Smithson, David C, Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jimenez-Diaz, Maria B, Martinez, Maria S, Wilson, Emily B, Tripathi, Abhai K, Gut, Jiri, Sharlow, Elizabeth R, Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Inigo, Ferrer, Santiago, Rosenthal, Philip J, DeRisi, Joseph L, Sullivan, David J, Lazo, John S, Roos, David S, Riscoe, Michael K, Phillips, Margaret A, Rathod, Pradipsinh K, Van Voorhis, Wesley C, Avery, Vicky M, Guy, R Kiplin   +34 more
openaire   +5 more sources