Results 11 to 20 of about 192,449 (275)
Protein Sorting in Plasmodium Falciparum [PDF]
Life, 2021 Plasmodium falciparum is a unicellular eukaryote with a very polarized secretory system composed of micronemes rhoptries and dense granules that are required for host cell invasion. P. falciparum, like its relative T. gondii, uses the endolysosomal system to produce the secretory organelles and to ingest host cell proteins.
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Detectability of Plasmodium falciparum clones [PDF]
Malaria Journal, 2010 In areas of high transmission people often harbour multiple clones of Plasmodium falciparum, but even PCR-based diagnostic methods can only detect a fraction (the detectability, q) of all clones present in a host. Accurate measurements of detectability are desirable since it affects estimates of multiplicity of infection, prevalence, and frequency of ...
Bretscher, M. T. +5 more
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Artemisinin resistance in Plasmodium falciparum [PDF]
The Lancet Infectious Diseases, 2014 Benoit Witkowski and colleagues reported a simple and rapid in vitro method to detect artemisinin resistance of P falciparum. They show that the slow clearance of parasites by artemisinin combination therapies is a result of a drop in susceptibility among young ring form parasites whereas susceptibility is maintained in mature stages.
Lun, Zhao-Rong +2 more
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Plasmodium falciparum and the brain [PDF]
BMC Proceedings, 2008 A unique characteristic of P. falciparum is that the infected erythrocytes sequester within the deep vascular beds, particularly those of the brain. The blood brain barrier appears to be impaired. The most common CNS manifestations are seizures, agitation, psychosis, impaired consciousness and coma (cerebral malaria), but there are differences in ...
Charles R. Newton, Charles R. Newton
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Chemical genetics of Plasmodium falciparum [PDF]
Nature, 2010 Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose
Guiguemde, W Armand +34 more
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Polymorphic antigens in Plasmodium falciparum [PDF]
Blood, 1989 5 years, a large number of these antigens have been cloned so that they may be investigated for their potential as components of a malaria vaccine. As a result of the sequencing studies on these cloned genes or gene fragments, a large amount of information has been obtained concerning the primary structural characteristics of Plasmodium fa/ciparum’ For
Jason Arthur Smythe, Robin F. Anders
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Trends in Parasitology, 2019 Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death due to a vector-borne infectious disease, claiming 0.5 million lives every year. The single-cell eukaryote undergoes a complex life cycle and is an obligate intracellular parasite of hepatocytes (clinically silent) and erythrocytes (disease causing).
Maier, Alex +3 more
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Emerging Topics in Life Sciences, 2017 Plasmodium falciparum is a protozoan parasite that causes the most severe form of human malaria. Five other Plasmodium species can also infect humans — P. vivax, P. malariae, P. ovale curtisi, P. ovale wallikeri and P. knowlesi — but P. falciparum is the most prevalent Plasmodium species in the African region, where 90% of all malaria occurs, and it is
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Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology [PDF]
, 2014 One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human ...
Dinglasan, R. R. +10 more
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The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation [PDF]
, 2012 <b>Background</b> Malaria parasites undergo, in the vertebrate host, a developmental switch from asexual replication to sexual differentiation leading to the formation of gametocytes, the only form able to survive in the mosquito vector ...
AG Maier +27 more
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