Results 11 to 20 of about 296,027 (331)

Chemical genetics of Plasmodium falciparum [PDF]

Nature, 2010
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic forward chemical genetic approach to assay 309,474 chemicals. Here we disclose
Guiguemde, W Armand, Shelat, Anang A, Bouck, David, Duffy, Sandra, Crowther, Gregory J, Davis, Paul H, Smithson, David C, Connelly, Michele, Clark, Julie, Zhu, Fangyi, Jimenez-Diaz, Maria B, Martinez, Maria S, Wilson, Emily B, Tripathi, Abhai K, Gut, Jiri, Sharlow, Elizabeth R, Bathurst, Ian, El Mazouni, Farah, Fowble, Joseph W, Forquer, Isaac, McGinley, Paula L, Castro, Steve, Angulo-Barturen, Inigo, Ferrer, Santiago, Rosenthal, Philip J, DeRisi, Joseph L, Sullivan, David J, Lazo, John S, Roos, David S, Riscoe, Michael K, Phillips, Margaret A, Rathod, Pradipsinh K, Van Voorhis, Wesley C, Avery, Vicky M, Guy, R Kiplin   +34 more
openaire   +5 more sources

Polymorphic antigens in Plasmodium falciparum [PDF]

Blood, 1989
5 years, a large number of these antigens have been cloned so that they may be investigated for their potential as components of a malaria vaccine. As a result of the sequencing studies on these cloned genes or gene fragments, a large amount of information has been obtained concerning the primary structural characteristics of Plasmodium fa/ciparum’ For
Jason Arthur Smythe, Robin F. Anders
openaire   +4 more sources

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

Malaria Journal, 2020
Background Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic ...
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich, Thierry Rolling   +5 more
doaj   +1 more source

Genomic epidemiology of artemisinin resistant malaria

eLife, 2016
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations.
MalariaGEN Plasmodium falciparum Community Project
doaj   +1 more source

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi [PDF]

, 2011
<b>Background:</b> Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P.
Alex McConnachie, Allan Macheso, B Haubold, BS Weir, C Roper, CJ Sutherland, DJ Conway, E Kosman, FE McKenzie, HM Gilles, J Goudet, J May, JM Vinetz, K Maitland, K Mugittu, L Henning, LH Taylor, M Tanner, Malcolm E Molyneux, Marian C Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MU Ferreira, N Fraser-Hurt, N Tanomsing, PCC Garnham, R Tahar, RD Page, RL Ord, S Enosse, S Nair, S Zakeri, T Smith, T Smith, T Smith, T Smith, The Ministry of Health and Population, TJ Anderson, TJC Anderson, TL Ritchie, WE Collins, WJ Collins   +44 more
core   +4 more sources

Characterization of Plasmodium falciparum glutamate dehydrogenase-soluble antigen

Brazilian Journal of Medical and Biological Research, 1998
The major aim of this study was to characterize a soluble Plasmodium falciparum antigen from the plasma of malaria-infected humans and Plasmodium falciparum culture supernatants, using immunoabsorbent techniques and Western blotting. An Mr 60-kDa protein
A. Rodríguez-Acosta, N.G. Domínguez, I. Aguilar, M.E. Girón   +3 more
doaj   +1 more source

Plasmodium malariae contributes to high levels of malaria transmission in a forest–savannah transition area in Cameroon

Parasites & Vectors, 2023
Background Malaria control efforts are highly skewed towards Plasmodium falciparum while overlooking other Plasmodium species such as P. malariae. A better understanding of the role of Plasmodium species other than P.
Daniel Nguiffo-Nguete, Francis Nongley Nkemngo, Cyrille Ndo, Jean-Pierre Agbor, Stravensky T. Boussougou-Sambe, Luc Salako Djogbénou, Francine Ntoumi, Ayôla A. Adegnika, Steffen Borrmann, Charles S. Wondji   +9 more
doaj   +1 more source

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015

Nature, 2015
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital to inform future control planning.
S. Bhatt, D. Weiss, E. Cameron, D. Bisanzio, B. Mappin, U. Dalrymple, K. Battle, C. Moyes, Andrew J. Henry, P. Eckhoff, E. Wenger, O. Briët, O. Briët, M. Penny, M. Penny, T. Smith, T. Smith, A. Bennett, J. Yukich, T. Eisele, J. Griffin, C. Fergus, Michael Lynch, F. Lindgren, Justin M. Cohen, C. Murray, Dave L. Smith, Simon Iain Hay, Simon Iain Hay, Simon Iain Hay, R. Cibulskis, P. Gething   +31 more
semanticscholar   +1 more source

Plasmodium falciparum [PDF]

Emerging Topics in Life Sciences, 2017
Plasmodium falciparum is a protozoan parasite that causes the most severe form of human malaria. Five other Plasmodium species can also infect humans — P. vivax, P. malariae, P. ovale curtisi, P. ovale wallikeri and P. knowlesi — but P. falciparum is the most prevalent Plasmodium species in the African region, where 90% of all malaria occurs, and it is
openaire   +2 more sources

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source