Results 251 to 260 of about 192,449 (275)

Glycobiology of Plasmodium falciparum

Biochimie, 2001
The human malaria parasite, Plasmodium falciparum, has as its only glycoconjugate GPI anchors. These structures, present in essentially all parasite surface proteins, are associated with disease pathology. In contrast, the parasite depends for essential recognition events on saccharides associated with host cell glycoproteins and proteoglycans.
D. Channe Gowda, Eugene A. Davidson
openaire   +3 more sources

Transfection of Plasmodium falciparum

2012
Genetic manipulation of Plasmodium falciparum remains very challenging, mainly due to the parasite genome's high A/T-richness and low transfection efficiency. This chapter includes methods for generating transient and stable transfections by electroporation, allelic replacement with tagged genes, gene deletion, and the analysis of all the above.
Melanie Rug, Alexander G. Maier
openaire   +3 more sources

Curation of the Plasmodium falciparum genome

Trends in Parasitology, 2004
The malaria genome has proved invaluable to researchers worldwide in the continuing fight against malaria by stimulating and underpinning molecular approaches in gene expression studies, vaccine and drug discovery research, and by providing data to facilitate hypothesis-driven research.
Berry, A.E., Gardner, M.J., Caspers, G.A.J., Roos, D.S., Berriman, M.   +4 more
openaire   +4 more sources

Plasmodium falciparum cytoadherence

Research in Immunology, 1991
Sherman, I.W. (1979), Biochemistry of Plasmodium (malaria parasites). Microbiol. Rev., 43, 453-495. Strych, W., Miettinen-Baumann, A., Lottspeich, F. & Heidrich, H. (1987), Isolation and characterisation of the 80,000 dalton Plasmodium falciparum merozoite surface antigen. Parasit. Res., 73, 435441. Stryer, L.
openaire   +3 more sources

Plasmodium falciparum: Attenuation by irradiation

Experimental Parasitology, 1983
The effect of irradiation on the in vitro growth of Plasmodium falciparum was investigated. The cultured malarial parasites at selected stages of development were exposed to gamma rays and the sensitivity of each stage was determined. The stages most sensitive to irradiation were the ring forms and the early trophozoites; late trophozoites were ...
Seiji Waki, Ichiro Yonome, Mamoru Suzuki
openaire   +3 more sources

Malabsorption in Plasmodium Falciparum Malaria

The American Journal of Tropical Medicine and Hygiene, 1972
Abstract Impaired gastrointestinal function was detected during the acute phase of illness in patients with Plasmodium falciparum malaria. Nine of 11 (82%) had diminished D-xylose absorption, 6 of 10 (60%) had decreased absorption of vitamin B12, and 5 of 11 (45%) had low serum carotene levels.
Walter W. Karney, Myron J. Tong
openaire   +3 more sources

Mating Patterns of Plasmodium falciparum

Parasitology Today, 1998
Recent empirical data have enabled a more informed debate over the extent of clonality in Plasmodium falciparum populations. Oocyst heterozygosity data reveal that the mating structure of malaria populations varies according to the transmission intensity.
R.E.L. Paul, Karen P. Day
openaire   +3 more sources

Codon usage in Plasmodium falciparum

Molecular and Biochemical Parasitology, 1988
The codon frequencies used in 7874 codons from 17 sequences of Plasmodium falciparum have been examined. The frequency distribution is markedly biased. A and C occur with similar frequency in all positions but G is predominantly in the first base and T is predominantly in the last position.
Allan Saul, Diana Battistutta
openaire   +3 more sources

Pigment biocrystallization in Plasmodium falciparum

Trends in Parasitology, 2002
Malaria parasites catabolize hemoglobin as an important source of amino acids. One consequence of this dependence on hemoglobin degradation is the need for an effective detoxification mechanism for hematin (Fig. 1Fig. 1a,b). To date, the only definitively characterized product of hematin in the parasite is the malaria pigment hemozoin.
Ernst Hempelmann, Timothy J. Egan
openaire   +3 more sources

Adenine metabolism in Plasmodium falciparum

Experimental Parasitology, 2010
Plasmodium falciparum lacks the de novo purine biosynthesis pathway and relies entirely on the salvage pathway to meet its purine nucleotide requirements. The entire flux for purine nucleotide biosynthesis in the parasite is believed to be through hypoxanthine guanine phosphoribosyltransferase (HGPRT), with the enzymes, adenosine kinase and adenine ...
Sonali Mehrotra, Vinay Bulusu, Monnanda P. Bopanna, Hemalatha Balaram   +3 more
openaire   +3 more sources