Results 21 to 30 of about 302,576 (367)

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Nature Medicine, 2020
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based combination therapy), is widespread across Southeast Asia but to date has not been reported in Africa1–4. Here we genotyped the P.
A. Uwimana, E. Legrand, Barbara H. Stokes, Jean-Louis Mangala Ndikumana, M. Warsame, Noella Umulisa, D. Ngamije, Tharcisse Munyaneza, J. Mazarati, Kaendi J. Munguti, P. Campagne, A. Criscuolo, F. Ariey, Monique Murindahabi, P. Ringwald, D. Fidock, A. Mbituyumuremyi, D. Ménard   +17 more
semanticscholar   +1 more source

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.

Annual Review of Microbiology, 2020
Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant to chloroquine, amodiaquine, or piperaquine harbor mutations in the P ...
Kathryn J. Wicht, Sachel Mok, D. Fidock
semanticscholar   +1 more source

Potensi vaksinasi P. Falciparum circumsporozoite protein adjuvan CAF09 (PF CSP-CAF09) untuk pencegahan malaria dengan induksi sel t CD8+

JKS (Jurnal Kedokteran Syiah Kuala), 2023
Malaria masih merupakan ancaman yang serius karena dapat menyerang siapa saja tanpa sistem imunitas yang adekuat dan dapat menyebar dengan cepat melalui vektornya.
Fandy Ong Jaya, Sugiono Namli, Melly Leman, Restuti Hidayani Saragih   +3 more
doaj   +1 more source

High prevalence of asymptomatic malaria infections in adults, Ashanti Region, Ghana, 2018

Malaria Journal, 2020
Background Ghana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic ...
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich, Thierry Rolling   +5 more
doaj   +1 more source

Genomic epidemiology of artemisinin resistant malaria

eLife, 2016
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations.
MalariaGEN Plasmodium falciparum Community Project
doaj   +1 more source

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi [PDF]

, 2011
<b>Background:</b> Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P.
Alex McConnachie, Allan Macheso, B Haubold, BS Weir, C Roper, CJ Sutherland, DJ Conway, E Kosman, FE McKenzie, HM Gilles, J Goudet, J May, JM Vinetz, K Maitland, K Mugittu, L Henning, LH Taylor, M Tanner, Malcolm E Molyneux, Marian C Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MC Bruce, MU Ferreira, N Fraser-Hurt, N Tanomsing, PCC Garnham, R Tahar, RD Page, RL Ord, S Enosse, S Nair, S Zakeri, T Smith, T Smith, T Smith, T Smith, The Ministry of Health and Population, TJ Anderson, TJC Anderson, TL Ritchie, WE Collins, WJ Collins   +44 more
core   +4 more sources

Characterization of Plasmodium falciparum glutamate dehydrogenase-soluble antigen

Brazilian Journal of Medical and Biological Research, 1998
The major aim of this study was to characterize a soluble Plasmodium falciparum antigen from the plasma of malaria-infected humans and Plasmodium falciparum culture supernatants, using immunoabsorbent techniques and Western blotting. An Mr 60-kDa protein
A. Rodríguez-Acosta, N.G. Domínguez, I. Aguilar, M.E. Girón   +3 more
doaj   +1 more source

Plasmodium malariae contributes to high levels of malaria transmission in a forest–savannah transition area in Cameroon

Parasites & Vectors, 2023
Background Malaria control efforts are highly skewed towards Plasmodium falciparum while overlooking other Plasmodium species such as P. malariae. A better understanding of the role of Plasmodium species other than P.
Daniel Nguiffo-Nguete, Francis Nongley Nkemngo, Cyrille Ndo, Jean-Pierre Agbor, Stravensky T. Boussougou-Sambe, Luc Salako Djogbénou, Francine Ntoumi, Ayôla A. Adegnika, Steffen Borrmann, Charles S. Wondji   +9 more
doaj   +1 more source

Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology [PDF]

, 2014
One of the critical gaps in malaria transmission biology and surveillance is our lack of knowledge about Plasmodium falciparum gametocyte biology, especially sexual dimorphic development and how sex ratios that may influence transmission from the human ...
Dinglasan, R. R., Goldowitz, I., Graham, D. R., King, J. G., Marti, M., Mathias, D. K., Moss, E., Pastrana-Mena, R., Tao, D., Tripathi, A., Ubaida-Mohien, C.   +10 more
core   +1 more source

Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis

PLoS Pathogens, 2020
New techniques for obtaining electron microscopy data through the cell volume are being increasingly utilized to answer cell biologic questions. Here, we present a three-dimensional atlas of Plasmodium falciparum ultrastructure throughout parasite cell ...
Rachel M. Rudlaff, S. Kraemer, J. Marshman, Jeffrey D. Dvorin   +3 more
semanticscholar   +1 more source