Results 41 to 50 of about 8,235 (174)

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

A TaqMan real-time PCR assay for the detection and quantitation of Plasmodium knowlesi

Malaria Journal, 2010
Background The misdiagnosis of Plasmodium knowlesi by microscopy has prompted a re-evaluation of the geographic distribution, prevalence and pathogenesis of this species using molecular diagnostic tools. In this report, a specific probe for P.
Singh Balbir, Shokoples Sandra E, Divis Paul CS, Yanow Stephanie K   +3 more
doaj   +1 more source

Spatial cluster analysis of Plasmodium vivax and P. malariae exposure using serological data among Haitian school children sampled between 2014 and 2016.

PLoS Neglected Tropical Diseases, 2022
BackgroundEstimation of malaria prevalence in very low transmission settings is difficult by even the most advanced diagnostic tests. Antibodies against malaria antigens provide an indicator of active or past exposure to these parasites.
Adan Oviedo, Camelia Herman, Alaine Knipes, Caitlin M Worrell, LeAnne M Fox, Luccene Desir, Carl Fayette, Alain Javel, Franck Monestime, Kimberly E Mace, Michelle A Chang, Jean F Lemoine, Kimberly Won, Venkatachalam Udhayakumar, Eric Rogier   +14 more
doaj   +1 more source

Plasmodium knowlesiMalaria in Children

Emerging Infectious Diseases, 2011
Plasmodium knowlesi can cause severe malaria in adults; however, descriptions of clinical disease in children are lacking. We reviewed case records of children (age
Bridget E. Barber, Timothy William, Mohammad Jikal, Jenarun Jilip, Prabakaran Dhararaj, Jayaram Menon, Tsin W. Yeo, Nicholas M. Anstey   +7 more
openaire   +3 more sources

Resurgence of Malaria in Protected and Rural Areas After Successful Control Program in a Brazilian Amazon Municipality

GeoHealth, Volume 10, Issue 7, July 2026.
Abstract Malaria eradication requires reducing transmission in endemic areas and maintaining these reductions in areas where elimination has been achieved. In Altamira, a municipality in the Xingu Basin of the Brazilian Amazon, a malaria control program was implemented during the construction of the Belo Monte Dam which eliminated local malaria cases ...
E. B. Skinner, D. de Angeli Dutra, É. Pelegrino, O. Damasceno, S. Burza, E. A. Mordecai   +5 more
wiley   +1 more source

Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

Malaria Journal, 2019
Background Malaria is endemic in Tanzania with majority of clinical cases caused by Plasmodium falciparum. Additionally, Plasmodium malariae and Plasmodium ovale spp.
Tobias Schindler, Said Jongo, Fabian Studer, Maximilian Mpina, Grace Mwangoka, Sarah Mswata, Kamaka Ramadhani, Julian Sax, L. W. Preston Church, Thomas L. Richie, Marcel Tanner, Stephen L. Hoffman, Salim Abdulla, Claudia Daubenberger   +13 more
doaj   +1 more source

An Atypical Aquaporin 1 Derived From Paramecium multimicronucleatum Functions as a Multifunctional Channel That Permeates Water, Glycerol, and Urea

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Although it had been reported that the translation product of the functional aquaporin gene, aqp1, is localized to the contractile vacuole complex of Paramecium multimicronucleatum, the molecules that pass through this channel protein had not been identified. In the present study, we introduced and expressed this protein in Xenopus oocytes and
Masaki Ishida, Shuichi Ueno, Takashi Tominaga, Kurumi Tanaka, Akito Horikawa, Manabu Hori   +5 more
wiley   +1 more source

Strong Cross‐Reactivity of Anti–Plasmodium falciparum pLDH Monoclonal Antibodies With Plasmodium malariae pLDH in the Abbott Bioline Malaria Ag P.f/P.f/P.v Rapid Diagnostic Test

Tropical Medicine &International Health, Volume 31, Issue 7, Page 944-952, July 2026.
ABSTRACT Objectives This study aimed to describe the cross‐reactivity of the Abbott Bioline Malaria Ag P.f/P.f/P.v rapid diagnostic test, designed to detect Plasmodium falciparum and P. vivax , with other Plasmodium species, based on the detection of parasite lactate dehydrogenase enzymes.
Gabriel Montoia, Maria Carmen Arroyo Sanchez, Giselle Lima‐Cooper, Maria de Lourdes Rego Neves Farinas, Juliana Inoue, Silvia Maria Di Santi   +5 more
wiley   +1 more source

Global prevalence and mortality of severe Plasmodium malariae infection: a systematic review and meta-analysis

Malaria Journal, 2020
Background Severe complications among patients with Plasmodium malariae infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. malariae infection in humans.
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. Masangkay   +3 more
doaj   +1 more source

Presence and potential distribution of malaria-infected New World primates of Costa Rica

Malaria Journal, 2022
Background In South and Central America, Plasmodium malariae/Plasmodium brasilianum, Plasmodium vivax, Plasmodium simium, and Plasmodium falciparum has been reported in New World primates (NWP).
Andrea Chaves, Gaby Dolz, Carlos N. Ibarra-Cerdeña, Genuar Núñez, Edgar Ortiz-Malavasi E, Sofia Bernal-Valle, Gustavo A. Gutiérrez-Espeleta   +6 more
doaj   +1 more source