Results 51 to 60 of about 27,835 (183)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

PLASMODIUM VIVAX BLOOD-STAGE DYNAMICS [PDF]

Journal of Parasitology, 2002
We examine the dynamics of parasitemia and gametocytemia reflected in the preintervention charts of 221 malaria-naive U.S. neurosyphilis patients infected with the St. Elizabeth strain of Plasmodium vivax, for malariatherapy, focusing on the 109 charts for which 15 or more days of patency preceded intervention and daily records encompassed an average ...
F Ellis, McKenzie, Geoffrey M, Jeffery, William E, Collins   +2 more
openaire   +2 more sources

A rare case of young stroke in 16 years old female with Plasmodium vivax malaria infection

Journal of Integrated Health Sciences, 2017
Malaria is the most important parasitic disease in the world, in terms of both prevalence and mortality. Infection rate is high due to raise of strains resistant to the antimalarial medicines & social factors.
N U Gediya, M K Marvaniya, D A Parmar, U S Gediya   +3 more
doaj   +1 more source

Rational Design of N‐2‐(7‐Chloroquinolin‐4‐ylamino)ethyl Amides Active Against Chloroquine‐Resistant Plasmodium falciparum

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
Of 22 chloroquine (CQ) analogs, 16 showed IC503D7 values of 27–555 nM; their activity against the CQ‐resistant K1 strain and in silico/vitro hepatotoxicity were evaluated. Benzamides with chlorine and nitro groups were most active, showing IC50K1 and RI values lower than CQ and cytotoxic concentrations well above inhibitory concentrations.
Everton P. Silva, Camila S. Barbosa, Anna C. C. Aguiar, Ramon G. Oliveira, Thiago A. M. Brito, Marcelo F. R. Silva, Helivaldo D. S. Souza, Petrônio F. Athayde‐Filho, Gabriela F. Fiss   +8 more
wiley   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine [PDF]

Malaria Journal, 2008
AbstractBackgroundPlasmodium vivaxis a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to thePlasmodiumspp. trophozoite, the stage when haemoglobin catabolism is maximal.
Wesley W Sharrock, Rossarin Suwanarusk, Usa Lek‐Uthai, Michael D. Edstein, Varakorn Kosaisavee, Thomas Travers, Anchalee Jaidee, Kanlaya Sriprawat, Ric N. Price, François Nosten, Bruce Russell   +10 more
openaire   +4 more sources

Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

Malaria Journal, 2019
Background Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malaria elimination in this country.
Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T. White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J. Tisch, Alyssa Barry, Celine Barnadas, James Kazura, Ivo Mueller   +12 more
doaj   +1 more source

Developmental Toxicity Study for the Antimalarial Drug Combination Cabamiquine‐Pyronaridine Using a Translational Approach

Birth Defects Research, Volume 118, Issue 10, October 2026.
ABSTRACT Background The safety of pharmacological treatments during pregnancy is a significant concern, as many medications lack comprehensive reproductive safety data. This creates gaps in therapeutic options for pregnant women, particularly malaria, which poses serious risks to maternal and fetal health.
Wookyung Kim, Geum‐Sil Cho, Andreas Gado, Tobias Hyun Ho Baeurle, Habib Karimi, Filippo Venezia, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha, Claudia Demarta‐Gatsi   +9 more
wiley   +1 more source

A Framework for Cross‐National Collective Intelligence Facilitation

Systems Research and Behavioral Science, EarlyView.
Owen M. Harney, Michael J. Hogan, Jenny M. Groarke, Jane C. Walsh   +3 more
wiley   +1 more source

Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?

Malaria Journal, 2022
Background The groundwork for malaria elimination does not currently consider the potential of Plasmodium zoonotic cycles that involve non-human primates (NHPs) in sylvatic environments. Since vivax malaria is less responsive to control measures, finding
Bárbara Aparecida Chaves, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Marcelo Gordo, Emanuelle L. Da Silva, Edson Rodrigues Costa, Aline Souza de Menezes Medeiros, Igor José Martins Pedrosa, Daniela Brito, Maurício Teixeira Lima, Maria Paula Mourão, Wuelton M. Monteiro, Nikos Vasilakis, Cristiana Ferreira Alves de Brito, Gisely C. Melo, Marcus V. G. Lacerda   +15 more
doaj   +1 more source

Explainable Machine Learning for Predicting Global Malaria Incidence From 2000 to 2022 With Climatic and Extreme Weather Conditions Across 78 Endemic Countries: A Retrospective Ecological Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Malaria remains a major global health concern, causing substantial morbidity and mortality, especially in tropical and subtropical regions with limited healthcare resources. Climatic conditions and extreme weather events are increasingly recognized as critical determinants of malaria transmission, yet their relative ...
Md. Abu Bokkor Shiddik, Md. Abdullah Al Fahad Sohan   +1 more
wiley   +1 more source