Results 81 to 90 of about 108,718 (219)

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.
Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha   +4 more
wiley   +1 more source

Plasmodium vivax trophozoites insensitive to chloroquine [PDF]

Malaria Journal, 2008
AbstractBackgroundPlasmodium vivaxis a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to thePlasmodiumspp. trophozoite, the stage when haemoglobin catabolism is maximal.
Wesley W Sharrock, Rossarin Suwanarusk, Usa Lek‐Uthai, Michael D. Edstein, Varakorn Kosaisavee, Thomas Travers, Anchalee Jaidee, Kanlaya Sriprawat, Ric N. Price, François Nosten, Bruce Russell   +10 more
openaire   +4 more sources

Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

Malaria Journal, 2019
Background Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malaria elimination in this country.
Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T. White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J. Tisch, Alyssa Barry, Celine Barnadas, James Kazura, Ivo Mueller   +12 more
doaj   +1 more source

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507)   +32 more
core   +1 more source

Deconstruction of Aspartic Protease Inhibitors Enables Fragment‐Based Discovery of Plasmepsin V Inhibitors

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova, Laura Ruduša, Diana Zelencova‐Gopejenko, Aigars Jirgensons, Raitis Bobrovs   +4 more
wiley   +1 more source

Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?

Malaria Journal, 2022
Background The groundwork for malaria elimination does not currently consider the potential of Plasmodium zoonotic cycles that involve non-human primates (NHPs) in sylvatic environments. Since vivax malaria is less responsive to control measures, finding
Bárbara Aparecida Chaves, Denise Anete Madureira de Alvarenga, Matheus de Oliveira Costa Pereira, Marcelo Gordo, Emanuelle L. Da Silva, Edson Rodrigues Costa, Aline Souza de Menezes Medeiros, Igor José Martins Pedrosa, Daniela Brito, Maurício Teixeira Lima, Maria Paula Mourão, Wuelton M. Monteiro, Nikos Vasilakis, Cristiana Ferreira Alves de Brito, Gisely C. Melo, Marcus V. G. Lacerda   +15 more
doaj   +1 more source

Acute Febrile Illness With Triple Co‐Infection: A Case Report on the Diagnostic Challenges of Overlapping Febrile Illnesses

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 35‐year‐old female presented with 5 days of fever, fatigue, and myalgia during the post‐monsoon season at Damak Hospital, Jhapa, Nepal. Clinical examination revealed fever (102.7°F), tachycardia (110 bpm), and crackles in the right lower lung field.
Santosh Basyal, Rahul Parajuli, Dipendra Prasad Yadav, Shardul Bhattarai, Kritick Bhandari, Shrijana Basyal, Gul Zaman, Rohit Parajuli   +7 more
wiley   +1 more source

Naturally acquired immune responses to P. vivax merozoite surface protein 3α and merozoite surface protein 9 are associated with reduced risk of P. vivax malaria in young Papua New Guinean children [PDF]

, 2013
Plasmodium vivax is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas. Although numerous P.
Kiniboro, B, Stanisic, Danielle, Koepfli, Cristian, Koepfli, C, Cristian Koepfli, Felger, Ingrid, Balwan Singh, Meyer, Esmeralda V. S., Esmeralda V S Meyer, Kiniboro, Benson, Ingrid Felger, Jiang, J, Mary R Galinski, Singh, B, Javati, Sarah, Danielle I Stanisic, Stanisic, DI, Javati, S, Felger, I, Enmoore Lin, Mueller, Ivo, Siba, P, Ivo Mueller, Galinski, MR, Lin, Enmoore, Peter Siba, Lin, E, Siba, Peter, Mueller, I, Stanisic, Danielle I., Galinski, Mary R., Sarah Javati, Jianlin Jiang, Jiang, Jianlin, Meyer, EVS, Singh, Balwan, Benson Kiniboro   +36 more
core   +2 more sources

Plasmodium vivax treatments [PDF]

Current Opinion in Infectious Diseases, 2011
For over 50 years, the treatment of Plasmodium vivax has relied on a combination of chloroquine and primaquine, but this strategy is under threat. Chloroquine efficacy is now compromised across much of the vivax endemic world and there are significant operational difficulties in deploying primaquine. We review the recent advances in P.
Price, R, Douglas, N, Anstey, N, von Seidlein, L   +3 more
openaire   +3 more sources