Results 141 to 150 of about 737,401 (286)

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Detection and Monitoring of Floating Plastic Debris on Inland Waters From Sentinel-2 Time Series

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Floating plastic debris on water surfaces imposes both short- and long-term burdens on nature. Hence, identifying and monitoring plastic is important to document the location and scale of the phenomenon.
Daniele Cerra, Stefan Auer, Adrian Baissero, Felix Bachofer   +3 more
doaj   +1 more source

Extent and reproduction of coastal species on plastic debris in the North Pacific Subtropical Gyre. [PDF]

Nat Ecol Evol, 2023
Haram LE, Carlton JT, Centurioni L, Choong H, Cornwell B, Crowley M, Egger M, Hafner J, Hormann V, Lebreton L, Maximenko N, McCuller M, Murray C, Par J, Shcherbina A, Wright C, Ruiz GM.   +16 more
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Plastic debris in a nesting leatherback turtle in French Guiana

, 2010
International audienceWe report a field observation of an adult female leatherback turtle (Dermochelys coriacea) expulsing 2.6 kg of plastic debris from her cloaca while nesting in French Guiana.
Virginie Plot, Georges, Jean-Yves, Jean-Yves Georges, Plot, Virginie   +3 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Preferential deposition of macroplastic on floodplains

Cambridge Prisms: Plastics
Floods have a large impact on the mobilization, distribution and retention of macroplastic in rivers. Some of the transported plastic is deposited on riverbanks and floodplains.
Rahel Hauk, Louise Schreyers, Martine van der Ploeg, Adriaan J. Teuling, Nicholas Wallerstein, Tim van Emmerik   +5 more
doaj   +1 more source

Plastic debris in freshwater systems worldwide

, 2022
Plastic debris is widespread in freshwater ecosystems, but a rigorous assessment of its global distribution has been hindered by a lack of comprehensive and comparable data. We performed the first standardized global survey of lakes to assess the quantity and type of plastics (>250μm).
Nava, Veronica, Aherne, Julian, Alfonso, María B., Geraldes, Ana Maria, Attermeyer, Katrin, Bao, Roberto, Bartrons, Mireia, Berger, Stella, Biernaczyk, Marcin, Bissen, Raphael, Brookes, Justin, Brown, David, Candian, Giulia, Cañedo-Argüelles, Miguel, Canle, Moisés, Capelli, Camilla, Cereijo, Jose Luís, Carballeira, Rafael, Chawchai, Sakonvan, Chen, Guangjie, Christensen, Søren T., Christoffersen, Kirsten Seestern, Eyto, Elvira de, Delgado, Jorge, Doubek, Jonathan, Dusaucy, Julia, Erina, Oxana, Ersoy, Zeynep, Feuchtmayr, Heidrun, Lepori, Fabio, Frezzotti, Maria Luce, Galafassi, Silvia, Gateuille, David, Gonçalves, Vítor Manuel da Costa, Grossart, Hans-Peter, Hamilton, David, Kangur, Külli, Kankılıç, Gökben Başaran, Kessler, Rebecca, Kiel, Christine, Krynak, Edward M., Leiva-Presa, Àngels, Matias, Miguel, Matsuzaki, Shin-Ichiro, McElarney, Yvonne, Mitchell, Mark, Messyasz, Beata, Mlambo, Musa, Motitsoe, Samuel N., Owens, Caroline, Özkundakci, Deniz, Pinnow, Solvig, Pociecha, Agnieszka, Raposeiro, Pedro M., Rõõm, Eva-Ingrid, Rotta, Federica, Salmaso, Nico, Scordo, Facundo, Sibomana, Claver, Siewert, Daniel, Stepanowska, Katarzyna, Sudeep, Chandra, Tavşanoğlu, Ülkü Nihan, Tereshina, Maria, Thompson, James, Tolotti, Monica, Valois, Amanda, Verburg, Piet, Wesolek, Brian, Weyhenmeyer, Gesa, Wu, Naicheng, Zawisza, Edyta, Zink, Lauren, Leoni, Barbara   +73 more
openaire   +1 more source