Results 41 to 50 of about 109,525 (254)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Fate of Biodegradable and Conventional Mulch Films in Agricultural Soils: Aging-Induced Microplastic Formation, Azoxystrobin Sorption–Desorption Dynamics, and Penicillium expansum Growth on Films

Agriculture
Agricultural mulch films are utilized to optimize crop yields. However, their extensive use is linked to environmental drawbacks, including microplastics (MPs) formation due to aging and pesticide adsorption. This study integrated three connected aspects
Urška Šunta, Karmen Godič Torkar, Andrijana Sever Škapin, Kristina Žagar Soderžnik, Kristina Ugrinović, Mojca Bavcon Kralj   +5 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Impact of Plastic Mulching on Microplastic Contamination in Mountainous Agricultural Soils

Journal of Sustainable Agriculture and Environment
Microplastics (MPs) have extensively contaminated both aquatic and terrestrial ecosystems, yet their distribution and impacts in soil—both a source and a sink for MPs—remain poorly understood, particularly in remote agricultural landscapes.
Aayusha Upreti, Roshan Babu Ojha, Susma Giri, Basant Giri   +3 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Recycling agricultural plastic mulch: limitations and opportunities in the United States

Circular Agricultural Systems
Plastic mulches have become an essential component of modern agriculture since their introduction in the 1950s. However, disposal of plastic mulches poses serious environmental challenges as plastics that are not considered biodegradable or compostable ...
Kwabena A. Sarpong, Funmilayo A. Adesina, Lisa W. DeVetter, Kun Zhang, Kevin DeWhitt, Karl R. Englund, Carol Miles   +6 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Preliminary Study on Microplastic Contamination in Black Sea Cetaceans: Gastrointestinal Analysis of Phocoena phocoena relicta and Tursiops truncatus ponticus

Animals
Plastic pollution is a global concern that has a significant impact on marine life. Plastic is widely used and has become a pervasive pollutant in marine environments.
Adrian Filimon, Andreea-Mădălina Ciucă, George-Emanuel Harcotă, Elena Stoica   +3 more
doaj   +1 more source

Report on marine plastic contaminant monitoring

, 2023
{"references": ["Programmi di Monitoraggio per la Strategia Marina Art. 11, D.lgs. 190/2010", "B. Wenneker, L. Oosterbaan, & Intersessional Correspondence Group on Marine Litter (ICGML), Guideline for Monitoring Marine Litter on the Beaches in the OSPAR Maritime Area. Edition 1.0 (London, UK, 2010).
Mikołaj Mazurkiewicz, Artur Palacz
openaire   +2 more sources