Results 31 to 40 of about 103,981 (264)
Applied SciencesThe coupled seepage–stress action has a significant deterioration effect on the structural face of the hydraulic tunnel enclosure, which intensifies the shear rupture tendency of the deteriorated structural face of the rock mass.
Zelin Niu +3 more
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矿业科学学报This study proposes to address the stability of roadway surrounding rock under three-dimensional stress field based on the Drucker-Prager criterion and the theory of elastic-plastic mechanics.
LIU Hongtao +4 more
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Research on large deformation mechanism of deep roadway with dynamic pressure
Energy Science & Engineering, 2020 In this paper, the large deformation mechanism of deep dynamic pressure roadway is studied from the perspective of the formation and development of plastic zone, and creep and damage of rock mass.
Lei Fan +3 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Applied Sciences, 2023 The plastic zone of the surrounding rock of the borehole is a high-quality channel for gas flow. Studying the distribution form of the plastic zone in the surrounding rock of the boreholes and the characteristics of the extended connection network is ...
Chao Yuan +4 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Analysis of Surrounding Rock Pressure of Deep Buried Tunnel considering the Influence of Seepage
Geofluids, 2022 This paper takes the surrounding rock of deep tunnel as the research object and considers the action mechanism under the influence of seepage. Based on the Mohr-Coulomb criterion, the stress mechanism of surrounding rock of deep buried tunnel is analyzed
Qingchen Yao +5 more
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Analysis of plastic zones in surrounding rocks around a circular tunnel considering the effect of intermediate principal stress and heterogeneity [PDF]
MATEC Web of Conferences, 2019 Based on a modified Mohr-Coulomb criterion with a non-uniform coefficient, a calculation method of plastic zone boundary of surrounding rocks in a circular tunnel in non-uniform stress field is established.
Deng Shuxin +5 more
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