Results 41 to 50 of about 99,891 (264)

Theoretical Study of the Evolution Characteristics of the Plastic Deformation Zone of Type I–II Composite Fractured Rock under Osmotic Pressure

Applied Sciences
The coupled seepage–stress action has a significant deterioration effect on the structural face of the hydraulic tunnel enclosure, which intensifies the shear rupture tendency of the deteriorated structural face of the rock mass.
Zelin Niu, Yun Cheng, Jiafeng Pei, Tian Xu   +3 more
doaj   +1 more source

Glial plasticity at nervous system transition zones

Biology Open, 2023
ABSTRACT The central and peripheral nervous systems (CNS and PNS, respectively) are two separate yet connected domains characterized by molecularly distinct cellular components that communicate via specialized structures called transition zones to allow information to travel from the CNS to the periphery, and vice versa.
openaire   +3 more sources

Approximate solution of plastic zone in surrounding rock under three-dimensional stress field based on Drucker-Prager strength criterion

矿业科学学报
This study proposes to address the stability of roadway surrounding rock under three-dimensional stress field based on the Drucker-Prager criterion and the theory of elastic-plastic mechanics.
LIU Hongtao, LIANG Jialu, HAN Zijun, LIU Qinyu, QIAO Zhongjin   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Research on large deformation mechanism of deep roadway with dynamic pressure

Energy Science & Engineering, 2020
In this paper, the large deformation mechanism of deep dynamic pressure roadway is studied from the perspective of the formation and development of plastic zone, and creep and damage of rock mass.
Lei Fan, Weijun Wang, Chao Yuan, Wenqing Peng   +3 more
doaj   +1 more source

Construction Method of Honeycomb Gas Flow Network Channel: Structure-Based and Engineering Response on Plastic Zone Distribution Form

Applied Sciences, 2023
The plastic zone of the surrounding rock of the borehole is a high-quality channel for gas flow. Studying the distribution form of the plastic zone in the surrounding rock of the boreholes and the characteristics of the extended connection network is ...
Chao Yuan, Lian-Xin Li, Lei Fan, Yue-Yang Xu, Jun-Jie Wu   +4 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Analysis of Surrounding Rock Pressure of Deep Buried Tunnel considering the Influence of Seepage

Geofluids, 2022
This paper takes the surrounding rock of deep tunnel as the research object and considers the action mechanism under the influence of seepage. Based on the Mohr-Coulomb criterion, the stress mechanism of surrounding rock of deep buried tunnel is analyzed
Qingchen Yao, Yukun Ma, Zongyang Xiao, Zudi Zhang, Yaxin Lu, Chenyang Liu   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Influence of Rock Thermal Stress on the Morphology and Expansion Pattern of the Plastic Zone in the Surrounding Rock of a Deep-Buried Tunnel under High Geothermal Temperature Conditions

Applied Sciences
The extent of the plastic zone is critical in determining the stability and extent of damage to the surrounding rock in tunnels, crucial for designing support structures and thermal insulation layers.
Yucong Yin, Haibo Jiang, Jun Zhang, Gongda Lu, Qinglin Li   +4 more
doaj   +1 more source