Results 41 to 50 of about 543,693 (304)

Research on large deformation mechanism of deep roadway with dynamic pressure

Energy Science & Engineering, 2020
In this paper, the large deformation mechanism of deep dynamic pressure roadway is studied from the perspective of the formation and development of plastic zone, and creep and damage of rock mass.
Lei Fan, Weijun Wang, Chao Yuan, Wenqing Peng   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Approximate solution of plastic zone in surrounding rock under three-dimensional stress field based on Drucker-Prager strength criterion

矿业科学学报
This study proposes to address the stability of roadway surrounding rock under three-dimensional stress field based on the Drucker-Prager criterion and the theory of elastic-plastic mechanics.
LIU Hongtao, LIANG Jialu, HAN Zijun, LIU Qinyu, QIAO Zhongjin   +4 more
doaj   +1 more source

Construction Method of Honeycomb Gas Flow Network Channel: Structure-Based and Engineering Response on Plastic Zone Distribution Form

Applied Sciences, 2023
The plastic zone of the surrounding rock of the borehole is a high-quality channel for gas flow. Studying the distribution form of the plastic zone in the surrounding rock of the boreholes and the characteristics of the extended connection network is ...
Chao Yuan, Lian-Xin Li, Lei Fan, Yue-Yang Xu, Jun-Jie Wu   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Analysis of Surrounding Rock Pressure of Deep Buried Tunnel considering the Influence of Seepage

Geofluids, 2022
This paper takes the surrounding rock of deep tunnel as the research object and considers the action mechanism under the influence of seepage. Based on the Mohr-Coulomb criterion, the stress mechanism of surrounding rock of deep buried tunnel is analyzed
Qingchen Yao, Yukun Ma, Zongyang Xiao, Zudi Zhang, Yaxin Lu, Chenyang Liu   +5 more
doaj   +1 more source

Analysis of API 5C3 failure prediction formulae for casing and tubing [PDF]

, 2012
Due to the increasing demand for oil and gas, coupled with the fact that oil reserves are becoming rather scarce, the petroleum industry is pushed to drill and complete deeper wells. Threaded connections are often the weakest link in this process and are
De Baets, Patrick, De Waele, Wim, Galle, Timothy, Staelens, Seppe   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Analysis of plastic zones in surrounding rocks around a circular tunnel considering the effect of intermediate principal stress and heterogeneity [PDF]

MATEC Web of Conferences, 2019
Based on a modified Mohr-Coulomb criterion with a non-uniform coefficient, a calculation method of plastic zone boundary of surrounding rocks in a circular tunnel in non-uniform stress field is established.
Deng Shuxin, Zheng Yonglai, Feng Lipo, Tuan Le Van, Yue Cuizhou, Wu Zhuorui   +5 more
doaj   +1 more source