Results 81 to 90 of about 1,472,006 (329)

Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]

, 2012
A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T., Baillie, G.S., Canton, D.A., Day, J.P., Gelman, I.H., Grimes, Q., Guercio, L.A., Havekes, R., Huang, T., Luczak, V., Nie, T., Park, A.J., Scott, J.D.   +12 more
core   +2 more sources

Neutrophil plasticity in the tumor microenvironment.

Blood, 2019
Neutrophils act as the body's first line of defense against infection and respond to diverse inflammatory cues, including cancer. Neutrophils display plasticity, with the ability to adapt their function in different inflammatory contexts.
Morgan A. Giese, Laurel E. Hind, A. Huttenlocher   +2 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke

Scientific Reports
In healthy adults different language abilities—sentence processing versus emotional prosody—are supported by the left (LH) versus the right hemisphere (RH), respectively.
Kelly C. Martin, Anna Seydell-Greenwald, Peter E. Turkeltaub, Catherine E. Chambers, William D. Gaillard, Elissa L. Newport   +5 more
doaj   +1 more source

A simplified microwave-based motion detector for home cage activity monitoring in mice

Journal of Biological Engineering, 2017
Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping.
Andreas Genewsky, Daniel E. Heinz, Paul M. Kaplick, Kasyoka Kilonzo, Carsten T. Wotjak   +4 more
doaj   +1 more source

Deep learning predicts path-dependent plasticity

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We show that material plasticity can be precisely and efficiently predicted by deep-learning methods. This approach is fundamentally different from the century-old theory of continuum plasticity because it is not iteratively tracing the ...
M. Mozaffar, R. Bostanabad, R. Bostanabad, Wei Chen, K. Ehmann, Jian Cao, M. Bessa   +6 more
semanticscholar   +1 more source

The Role of BDNF on Neural Plasticity in Depression

Frontiers in Cellular Neuroscience, 2020
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala ...
Tao Yang, Zheng Nie, Hai-Feng Shu, Y. Kuang, Xin Chen, Jing-min Cheng, Sixun Yu, Huiying Liu   +7 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Beyond buying time: the role of plasticity in phenotypic adaptation to rapid environmental change

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019
How populations and species respond to modified environmental conditions is critical to their persistence both now and into the future, particularly given the increasing pace of environmental change.
R. Fox, J. Donelson, C. Schunter, T. Ravasi, J. Gaitán‐Espitia   +4 more
semanticscholar   +1 more source