Results 81 to 90 of about 1,298,913 (269)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Optimal storage and recall with biologically plausible synapses [PDF]

, 2011
Synaptic plasticity is widely accepted to underlie learning and memory. Yet, models of associative networks with biologically plausible synapses fail to match brain performance: memories stored in such networks are quickly overwritten by ongoing ...
Cristina Savin, Mate Lengyel
core   +2 more sources

The Plasticity of Mimesis [PDF]

MLN, 2017
This article inscribes Catherine Malabou's recent philosophical account of brain plasticity in a genealogy that goes, from Lacoue-Labarthe, back to its mimetic origins in Plato's Republic. Este artículo inscribe el reciente relato filosófico de Catherine Malabou sobre la plasticidad cerebral en una genealogía que se remonta, desde Lacoue-Labarthe, a ...
openaire   +4 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors

iScience, 2023
Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair, Kevin A. Wilkinson, Busra P. Yucel, Christophe Mulle, Bryce Vissel, Jack Mellor, Jeremy M. Henley   +6 more
doaj  

A simplified microwave-based motion detector for home cage activity monitoring in mice

Journal of Biological Engineering, 2017
Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping.
Andreas Genewsky, Daniel E. Heinz, Paul M. Kaplick, Kasyoka Kilonzo, Carsten T. Wotjak   +4 more
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Functional partitioning of sentence processing and emotional prosody in the right perisylvian cortex after perinatal stroke

Scientific Reports
In healthy adults different language abilities—sentence processing versus emotional prosody—are supported by the left (LH) versus the right hemisphere (RH), respectively.
Kelly C. Martin, Anna Seydell-Greenwald, Peter E. Turkeltaub, Catherine E. Chambers, William D. Gaillard, Elissa L. Newport   +5 more
doaj   +1 more source

Spiking Neural P Systems with Structural Plasticity: Attacking the Subset Sum Problem [PDF]

, 2015
Spiking neural P systems with structural plasticity (in short, SNPSP systems) are models of computations inspired by the function and structure of biological neurons. In SNPSP systems, neurons can create or delete synapses using plasticity rules.
Cabarle, Francis George C., Hernández, Nestine Hope S., Martínez del Amor, Miguel Ángel   +2 more
core   +1 more source

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Nature, 2019
Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation.
K. Vriens, Stefan Christe, S. Parik, D. Broekaert, Kazuaki Yoshinaga, A. Talebi, J. Dehairs, Carmen Escalona-Noguero, Robert Schmieder, T. Cornfield, C. Charlton, L. Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, M. Orth, R. Boon, Axelle Kerstens, Suet-Ying Kwan, B. Faubert, Andrés Méndez-Lucas, C. Kopitz, Ting Chen, J. Fernández-García, João A. G. Duarte, A. Schmitz, Patrick Steigemann, M. Najimi, Andreas Hägebarth, J. V. Van Ginderachter, E. Sokal, N. Gotoh, Kwok-kin Wong, C. Verfaillie, R. Derua, S. Munck, M. Yuneva, L. Beretta, R. Deberardinis, J. Swinnen, L. Hodson, D. Cassiman, C. Verslype, Sven Christian, S. Grünewald, T. G. Grünewald, S. Fendt   +45 more
semanticscholar   +1 more source