Results 31 to 40 of about 4,016,984 (212)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
A numerical study of crack shielding and deflection under extensive plasticity [PDF]
, 2009 Experimentally observed crack deflection events in multi-layered material systems, occurring even under pure mode-I loading, are here simulated and explained through elasto-plastic finite element modelling.
Reed, Philippa A.S. +2 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Closure Effect of I + II Mixed-mode Crack for EA4T Axle Steel
Chinese Journal of Mechanical EngineeringThe crack-closure effect is a crucial factor that affects the crack growth rate and should be considered in simulation analysis and testing. A mixed-mode I + II loading fatigue crack growth test was performed using EA4T axle steel specimens.
Shuancheng Wang +4 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Plasticity induced crack closure: a sensitivity analysis [PDF]
, 2012 Plasticity induced crack closure (PICC) is closely linked to the monotonic and reversed plastic deformation occurring at the crack tip. The objective of the paper is to identify the different physical and numerical parameters affecting PICC, and ...
Correia, Luís M. +2 more
core +1 more source
Investigation of plasticity-induced fatigue crack closure [PDF]
, 2007 : Plasticity induced crack closure and constraint effects due to finite plate thickness are both fundamental aspects in the mechanics of fatigue cracks. Moreover, plasticity induced crack closure provides an effective first-order correction to the crack ...
Codrington, J. +6 more
core +1 more source
Short fatigue crack growth in welded joints described by the effective cyclic J-integral
MATEC Web of Conferences, 2018 The purpose of the present contribution is to predict the fatigue life of welded joints by using the effective cyclic J-integral as crack driving force.
Tchoffo Ngoula Désiré +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source