Results 31 to 40 of about 66,365 (223)
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Flexural Behavior of Bidirectionally Graded Lattice
Advanced Engineering Materials, EarlyView., 2023 An experimental study of the bending behavior of bidirectional body‐centered cubic lattice beams is conducted in comparison to uniform and unidirectional counterparts of electron beam melted SS 316 L. Experimental results are used to develop and validate a finite element model which is subsequently used to conduct parametric studies to assess the ...
Chamini Rodrigo +4 more
wiley +1 more source
Directions of Curvature as an Explanation for Loss of Plasticity [PDF]
arXiv, 2023 Loss of plasticity is a phenomenon in which neural networks lose their ability to learn from new experience. Despite being empirically observed in several problem settings, little is understood about the mechanisms that lead to loss of plasticity. In this paper, we offer a consistent explanation for loss of plasticity: Neural networks lose directions ...
arxiv
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials
Advanced Engineering Materials, EarlyView., 2023 Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis +3 more
wiley +1 more source
A canonical rate-independent model of geometrically linear isotropic gradient plasticity with isotropic hardening and plastic spin accounting for the Burgers vector [PDF]
Continuum Mechanics and Thermodynamics, 2019, 2016 In this paper we propose a canonical variational framework for rate-independent phenomenological geometrically linear gradient plasticity with plastic spin. The model combines the additive decomposition of the total distortion into non-symmetric elastic and plastic distortions, with a defect energy contribution taking account of the Burgers vector ...
arxiv +1 more source
Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Fracture in distortion gradient plasticity [PDF]
arXiv, 2020 In this work, distortion gradient plasticity is used to gain insight into material deformation ahead of a crack tip. This also constitutes the first fracture mechanics analysis of gradient plasticity theories adopting Nye's tensor as primal kinematic variable. First, the asymptotic nature of crack tip fields is analytically investigated.
arxiv
Critical periods and Autism Spectrum Disorders, a role for sleep [PDF]
arXiv, 2022 Brain development relies on both experience and genetically defined programs. Time windows where certain brain circuits are particularly receptive to external stimuli, resulting in heightened plasticity, are referred to as critical periods. Sleep is thought to be essential for normal brain development.
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source