Results 61 to 70 of about 424,182 (313)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Easy and Green Method to Fabricate Highly Thermally Conductive Poly(decamethylene terephthalamide)/Graphite Nanoplatelets Nanocomposite with Aligned Structure

Molecules
With the development of miniaturization and integration of electrical and electronic equipment, the heat accumulation problems caused by the long-term operation of devices have become more and more serious.
Pengyuan Xu, Tianhao Ai, Pingli Wang, Junhui Ji   +3 more
doaj   +1 more source

A Simple Methodology to Better Appreciate Structures in Mandibular Angle Fractures Using 3-Dimensional Reconstruction Software [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: In Singapore, fractures of the mandible are common and of which, 32% occur at its angle. Current TwoDimensional (2D) imaging methods are lacking in accuracy, leading to increased surgical morbidity.
Arjunan Kumaran, Wen Chao Chew, Chor Hoong Hing, Winston Tan, Thiam Chye Tan   +4 more
doaj   +1 more source

The physical oceanography of the transport of floating marine debris [PDF]

, 2020
Marine plastic debris floating on the ocean surface is a major environmental problem. However, its distribution in the ocean is poorly mapped, and most of the plastic waste estimated to have entered the ocean from land is unaccounted for.
Aliani, Stefano, Alsina, José M., Bagaev, Andrei, Bergmann, Melanie, Chapron, Bertrand, Chubarenko, Irina, Cózar, Andrés, Delandmeter, Philippe, Egger, Matthias, Fox-Kemper, Baylor, Garaba, Shungudzemwoyo P., Goddijn-Murphy, Lonneke, Hardesty, Britta Denise, Hoffman, Matthew J., Isobe, Atsuhiko, Jongedijk, Cleo E., Kaandorp, Mikael L.A., Khatmullina, Liliya, Koelmans, Albert A., Kukulka, Tobias, Laufkötter, Charlotte, Law, Kara Lavender, Lebreton, Laurent, Lobelle, Delphine, Maes, Christophe, Marine and Atmospheric Research, Martinez-Vicente, Victor, Maximenko, Nikolai, Morales Maqueda, Miguel Angel, Poulain-Zarcos, Marie, Rodríguez, Ernesto, Ryan, Peter G., Shanks, Alan L., Shim, Won Joon, Suaria, Giuseppe, Sub Physical Oceanography, Thiel, Martin, Van Den Bremer, Ton S., Van Sebille, Erik, Wichmann, David   +39 more
core   +7 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Biomimetic Cellulose Nanocrystals Composite Hydrogels: Recent Progress in Surface Modification and Smart Soft Actuator Applications

Nanomaterials
Cellulose nanocrystals (CNCs), derived from renewable biomass, have emerged as a pivotal component in the design of biomimetic composite hydrogels due to their exceptional mechanical strength, biocompatibility, and tunable surface chemistry.
Yuzhu Cui, Zekai Wang, Mingliang Zhao, Zhihui Wang, Lu Zong   +4 more
doaj   +1 more source

Rotating filters permit wide range of optical pyrometry [PDF]

, 1965
Gear-driven dual filter disks of graduated density vary linearly with respect to rotation, allowing a wide range of photographic pyrometry.
Exton, R. J., Siviter, J. H., Jr., Strass, H. K.   +2 more
core   +1 more source

Biodegradability standards for carrier bags and plastic films in aquatic environments: a critical review [PDF]

, 2018
Plastic litter is encountered in aquatic ecosystems across the globe, including polar environments and the deep sea. To mitigate the adverse societal and ecological impacts of this waste, there has been debate on whether ‘biodegradable’ materials should ...
Ardisson GB, Association Française de Normalisation (AFNOR), ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, ASTM International, Bergmann M, De Wilde B, Harrison JP, Imam SH, International Organization for Standardization (ISO), International Organization for Standardization (ISO), International Organization for Standardization (ISO), Müller R-J, Müller R-J, Sharabi NE, The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI), The British Standards Institution (BSI)., The British Standards Institution (BSI)., Yabannavar AV   +33 more
core   +4 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Crystallization modeling of two semi-crystalline polyamides during material extrusion additive manufacturing

Scientific Reports
In this work, a heat transfer model is developed for thermally-driven material extrusion additive manufacturing of semicrystalline polymers that considers the heat generated during crystallization by coupling crystallization kinetics with heat transfer ...
Masoumeh Pourali, Ahmed Adisa, Shalmali Salunke, Amy M. Peterson   +3 more
doaj   +1 more source