Results 111 to 120 of about 3,860,038 (286)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Flow Visualisation Studies On Wall Mounted Pitot Type Intake With Splitter Plate [PDF]
, 1991 Flow Visualisation Studies Employing Schlieren/Shadowgraph Technique And -Simple Oil Flow Technique Were Carried Out On A Simple Pitot Type Of 1-Btake With Splitter Plate Mounted On Base Plate In The NAL 0 .3m Tunnel .
Narasimhaswamy, KN, Ramaswamy, MA
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
MODELING CONTROL PROCESSES OF UNSTEADY SEPARATED FLOW IN THE NEAR WAKE
Научный вестник МГТУ ГА, 2016 The paper shows possibility of implementing the open source CFD software package OpenFOAM for calculation of unsteady vortex flows in researching of flow past cylinder with plate.
V. T. Kalugin +2 more
doaj
BioengineeringBackground Context: This study’s purpose was to evaluate the biomechanical performance of plate–nail and dual-plate fixation for the treatment of AO/OTA 41-C2 tibial plateau fractures.
Wei Xie +7 more
doaj +1 more source
The Effect of the Width of an Aluminum Plate on a Bouncing Steel Ball [PDF]
Journal of Science International School Bangkok, 2013 The effect of the distance between clamping supports of an aluminum alloy plate on the coefficient of restitution of a bouncing steel ball was investigated. The plate was supported on two wooden blocks with a meter stick secured on either side.
Christine Hathaway, Hanh Nguyen
doaj
Social health insurance: The major driver of unsustainable fiscal policy? [PDF]
During the next decades the populations of most developed countries will grow older as a result of the low level of birth rates since the 1970s and/or the continuously increasing life expectancy.
Hagist, Christian +3 more
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source