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Seminal Platelet-Activating Factor
Seminars in Thrombosis and Hemostasis, 2007Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues.
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Platelet-activating factor acetylhydrolase
Prostaglandins & Other Lipid Mediators, 2002Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of PAF induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH)
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Platelet-activating factor and asthma
Journal of Allergy and Clinical Immunology, 1988anaphylaxis. And if you research into the 1920s) there a very useful treatment in blocking both thrombocyare articles, particularly in the German literature, that topenia and some of the features of anaphylaxis. The report thrombocytopenia as being a feature of clinical first article (1924) stated that heparin totally prevents asthma.
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Platelet-Activating Factor and Platelet-Activating Factor Antagonists in Acute Pancreatitis
Digestive Surgery, 1999<i>Introduction:</i> Acute pancreatitis causes platelet-activating factor (PAF) to be released which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF has also been implicated as a key mediator in the progression of severe acute pancreatitis, which can lead to complications and unacceptably
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Monographs in allergy, 1977
Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
J, Benveniste, J, Camussi, J, Polonsky
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Resume Il existe dans les basophiles et les mastocytes de nombreuses especes de mammiferes un facteur agregeant les plaquettes qui represente par consequent un lien entre la pathologie liee a la degranulation des basophiles/mastocytes, c'est-a-dire l'hypersensibilite immediate, et les plaquettes sanguines.
J, Benveniste, J, Camussi, J, Polonsky
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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2016
Platelet-activating factor (PAF) is a phospholipid produced by a variety of cells including platelets, endothelial cells, neutrophils, monocytes and macrophages. It has a wide range of potent biological activities including wound healing, physiological inflammation, apoptosis, angiogenesis, reproduction and long-term potentiation.
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Platelet-activating factor (PAF) is a phospholipid produced by a variety of cells including platelets, endothelial cells, neutrophils, monocytes and macrophages. It has a wide range of potent biological activities including wound healing, physiological inflammation, apoptosis, angiogenesis, reproduction and long-term potentiation.
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2000
Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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Research leading to the discovery of platelet-activating factor (PAF) came from studying a reaction that triggered platelets to release histamine. It was attributed to a factor actively released from leukocytes. Platelet-activating factor was first identified by Benveniste et al. in 1972.1 Later it was recognized that this phospholipid mediator is also
M. Poeze +3 more
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1995
Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet activating factor (PAF) is a low molecular weight, ether-linked phospholipid originally identified as a soluble factor, released from sensitized rabbit basophils during IgE anaphylaxis, that was capable of aggregating rabbit platelets [1, 2]. Cellular sources of PAF subsequently identified include neutrophil [3–8] and eosinophil granulocytes ...
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Platelet-activating factor receptor
Journal of Lipid Mediators and Cell Signalling, 1995T, Izumi +6 more
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