Results 71 to 80 of about 1,198,051 (418)
Frontiers in Pharmacology, 2021 Compound Kushen Injection (CKI) is a bis-herbal formulation extracted from Kushen (Radix Sophorae Flavescentis) and Baituling (Rhizoma Heterosmilacis Yunnanensis). Clinically, it is used as the adjuvant treatment of cancer.
Yuan Gao +9 more
doaj +1 more source
Risk factor aggregation and stress testing [PDF]
arXiv, 2023 Stress testing refers to the application of adverse financial or macroeconomic scenarios to a portfolio. For this purpose, financial or macroeconomic risk factors are linked with asset returns, typically via a factor model. We expand the range of risk factors by adapting dimension-reduction techniques from unsupervised learning, namely PCA and ...
arxiv
Journal of Clinical Investigation, 1985 Cultured human endothelial cells synthesize prostacyclin (PGI2), a potent inhibitor of platelet function, when stimulated with histamine, bradykinin, or ATP.
T. M. Mcintyre +6 more
semanticscholar +1 more source
Identification of Functional Platelet-Activating Factor Receptors on Human Keratinocytes [PDF]
, 1995 Platelet-activating factor (PAP) is a potent inflammatory mediator that has been shown to be produced by human keratinocytes and is thought to play a role in cutaneous inflammation, Immunofluorescence and radioligand binding studies were used to ...
Clark Huff, J. +5 more
core +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
On Factor Left Prime Factorization Problems for Multivariate Polynomial Matrices [PDF]
arXiv, 2020 This paper is concerned with factor left prime factorization problems for multivariate polynomial matrices without full row rank. We propose a necessary and sufficient condition for the existence of factor left prime factorizations of a class of multivariate polynomial matrices, and then design an algorithm to compute all factor left prime ...
arxiv
Proceedings of the National Academy of Sciences of the United States of America, 1984 Cultured human endothelial cells produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) when stimulated with human thrombin. The response to thrombin is dose dependent, with a half-maximal effect at 0.17 unit/ml.
S. Prescott, G. Zimmerman, T. McIntyre
semanticscholar +1 more source
Activation of human NK cells by Plasmodium-infected red blood cells.
, 2012 This chapter describes a protocol to assess activation of human NK cells following in vitro stimulation with malaria-infected red blood cells. Activation is assessed by flow cytometry, staining for cell surface expression of CD69 and accumulation of ...
Horowitz, Amir, Riley, Eleanor M
core +1 more source
Receptor-independent metabolism of platelet-activating factor by myelogenous cells [PDF]
, 1989 Human neutrophils incorporate and metabolize platelet-activating factor (PAF). We dissociated these events from PAF binding to its receptors. Cells were pretreated with either pronase, a PAF antagonist (L652731), or excess PAF.
Chabot, Marie C. +4 more
core +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source