Results 221 to 230 of about 24,574 (253)
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Tritiated hexadecyl platelet activating factor (PAF)
Journal of Labelled Compounds and Radiopharmaceuticals, 1985AbstractWe report the synthesis of the natural isomer of [3H]‐lyso platelet activating factor, [3H]‐lyso PAF (1‐0‐[9′,10′‐3H2]‐hexadecyl‐2‐lyso‐sn‐glycero‐3‐phosphocholine) and its conversion by acetylation to [3H]‐PAF(1‐0‐[9′,10′‐3H2]‐hexadecyl‐2‐acetylsn‐glycero‐3‐phosphocholine) for use in in vitro and in vivo metabolic studies.
Steven D. Wyrick +3 more
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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Structural analogs of platelet-activating factor (PAF-acether)
Biochimie, 1981Platelet-activafing factor (PAF-acether) is a potent mediator of anaphylaxis and inflammation. It induces aggregation of platelets mad releases their vasoactive amines. PAF-acether has' been shown to be produced by basophils [1, 2], macrophages [3, 4], neutrophils [51, and platelets themselves [6].
M, Tence +5 more
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Platelet-activating factor (PAF)-antagonists of natural origin
Fitoterapia, 2013Presently herbal medicines are being used by about 80% of the world population for primary health care as they stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. The discovery of platelet activating factor antagonists (PAF antagonists) during these decades are going on with different framework, but the ...
Preeti, Singh +4 more
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Platelet-activating factor (PAF-acether): Present status
Agents and Actions, 1981PAF-acether, first discovered in 1971-72, is now recognized as a 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine released from various cells and organs, including macrophages, neutrophils, platelets, the kidney and heart. In this review, we will concentrate on the newest aspects of PAF-acether biochemistry and pathophysiology: (1) PAF-acether is ...
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Biochemical and Biophysical Research Communications, 1985
A novel amidophosphonate analog of Platelet Activating Factor (PAF), trimethyl (3-phosphonopropyl) ammonium hydroxide (R)-mono[2-acetamido-3-(hexadecyloxy)propyl] ester (PAF-AP), was synthesized. A potent inhibitor of aggregation induced by Platelet Activating Factor, arachidonic acid, Ca2+-ionophore, ADP, and thrombin, PAF-AP had no or very little ...
M, Steiner +3 more
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A novel amidophosphonate analog of Platelet Activating Factor (PAF), trimethyl (3-phosphonopropyl) ammonium hydroxide (R)-mono[2-acetamido-3-(hexadecyloxy)propyl] ester (PAF-AP), was synthesized. A potent inhibitor of aggregation induced by Platelet Activating Factor, arachidonic acid, Ca2+-ionophore, ADP, and thrombin, PAF-AP had no or very little ...
M, Steiner +3 more
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Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Progress in Lipid Research, 2000Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator. Although PAF was initially recognized for its potential to induce platelet aggregation and secretion, intense investigations have elucidated potent biological actions of PAF in a broad range of cell types and tissues, many of
S, Ishii, T, Shimizu
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“CARBATHIA” ANALOGUES OF PLATELET ACTIVATING FACTOR (PAF)
Phosphorous and Sulfur and the Related Elements, 1986Abstract Sulfur analogues of “2-carba” PAF, 1a and 1b, were prepared by an 8-step synthesis using commercially available ethyl levulinate as a starting material.
Jeffery B. Press +3 more
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Rabbit blastocysts accumulate platelet‐activating factor (PAF) and lyso‐PAF in vitro
Molecular Reproduction and Development, 1992AbstractPlatelet‐activating factor (1‐O‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and has been demonstrated to bind specifically to rabbit uterine ...
M A, Jones, G B, Kudolo, M J, Harper
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Molecular modeling on platelet‐activating factor (PAF) and new proposed PAF antagonists
International Journal of Quantum Chemistry, 1996Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells.
Carlos M. R. De Sant'anna +4 more
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