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Platelet-activating factor (PAF) and PAF antagonists in asthma.
Critical reviews in therapeutic drug carrier systems, 1991PAF is produced by and activates inflammatory cells, such as monocytes/macrophages, mast cells, platelets, neutrophils, eosinophils and endothelial cells. Its ability to imitate anaphylaxis, inducing for instance bronchoconstriction (BC) in guinea-pigs, and its identification (and/or that of lyso-PAF) in exudates from shocked lungs, led to the ...
D, Hosford +2 more
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PLATELET-ACTIVATING FACTOR (PAF) IN EXPERIMENTAL AND CLINICAL SEPSIS
Shock, 1997Despite considerable progress in understanding the pathogenic mechanisms of Gram-negative sepsis, the outcome of septic patients has not significantly improved. There are ample data that support a role for inflammatory mediators in sepsis that act in synergy with infectious agents to initiate and propagate the disease process.
G, Mathiak +4 more
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Release, purification, and characterization of platelet-activating factor (PAF)
Biochimie, 1980Platelet-activating factor (PAF) is a phospholipid mediator, released by basophils, macrophages and neutrophils under immunological and non immunological stimuli. It aggregates platelets and liberates their vasoactive contents. We studied the "spontaneous" release of PAF from hog blood leukocytes : optimal conditions were 22 degrees C, pH 9.5 in BSA ...
V, Tencé +3 more
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[Platelet activating factor (PAF) and kidney failure progression].
Minerva medica, 1997Many mediators of phlogosis may play an important role in renal glomerular pathology. PAF seems to have a prominent role. The aim of this study is the evaluation of the mechanism of action by which PAF may contribute to renal glomerular damage.
Camici M, CARPI, ANGELO, Sagripanti A.
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Platelet-Activating Factor and PAF-Like Mimetics
1996Platelet-activating factor (PAF; 1-O-alkyl–2-acetyl-sn-glycero-3-phosphocholine; Fig. 7-1) is a potent bioactive lipid, with a diverse array of biologic effects in isolated systems, and which has as many roles in inflammatory states in vivo. Its name comes from observations in 1972 that a lipid extracted from the blood of rabbits undergoing anaphylaxis
Ralph E. Whatley +3 more
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Platelet-Activating Factor (PAF) in Infectious Diseases
2015Platelet-activating factor (PAF) is a phospholipid that was originally discovered as an IgE-sensitized rabbit basophil-derived substance responsible for platelet aggregation. The chemical structure was determined to be 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine. The cellular effects of PAF are mediated by a specific G protein-coupled receptor (PAFR)
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