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PLATELET-ACTIVATING FACTOR (PAF) IN EXPERIMENTAL AND CLINICAL SEPSIS
Shock, 1997 Despite considerable progress in understanding the pathogenic mechanisms of Gram-negative sepsis, the outcome of septic patients has not significantly improved. There are ample data that support a role for inflammatory mediators in sepsis that act in synergy with infectious agents to initiate and propagate the disease process.
G, Mathiak +4 more
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Platelet-activating factor (PAF)-antagonists of natural origin
Fitoterapia, 2013Presently herbal medicines are being used by about 80% of the world population for primary health care as they stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. The discovery of platelet activating factor antagonists (PAF antagonists) during these decades are going on with different framework, but the ...
Preeti, Singh +4 more
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Platelet activating factor (PAF) and lyso-PAF in psoriasis
Archives of Dermatological Research, 1994Previous studies have shown that scale from lesional psoriatic skin contains substantial amounts of platelet activating factor (PAF). In this study, PAF and its immediate precursor, lyso-PAF, were measured in exudates from abrasions on lesional and uninvolved psoriatic skin, and from skin of healthy subjects.
M R, Judge +5 more
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Procoagulant property of platelet activating factor (PAF)
Agents and Actions, 1993Platelet-activating factor (PAF) is known to activate platelets and thus promote clot formation in most mammalian species including humans. In this communication, the ability of PAF to hasten the overall coagulation process by measuring the recalcification time (RT) is described.
G W, Raff +3 more
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Platelet-Activating Factor Acetylhydrolase (PAF-AH)
Journal of Biochemistry, 2002Platelet-activating factor (PAF) is one of the most potent lipid messengers involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity, and its deacetylation induces loss of activity. The deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH).
Hiroyuki, Arai +3 more
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The specificity of the binding of platelet activating factor (PAF) to anti‐PAF antibodies
Journal of Molecular Recognition, 1990AbstractQuantitative hapten inhibition experiments employing sheep anti‐PAF antibodies and selected PAF analogues were undertaken with the aim of defining the antigenic determinant structures complementary to the antibody combining sites. The most important fine structural features for inhibition of antibody binding to PAF were shown to be an acetyl ...
M A, Smal, B A, Baldo, D G, Harle
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Inhibitor(s) of Platelet-Activating Factor (PAF) in Human Saliva
Lipids, 1991AbstractQuantitation of platelet‐activating factor (PAF) in human saliva samples by radioimmunoassay indicated there was, at times, sufficient PAF present to aggregate platelets. However, in certain samples, we observed little or no aggregation, and furthermore, these samples were found to inhibit aggregation induced by PAF (200 pg).
M A, Smal, B A, Baldo
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Paf-acether (Platelet-activating Factor)
1986Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine was unveiled in 1979, it was thus named “Paf-acether”, given the ether linkage at position 1 and the acetyl group at position 2 of glycerol. Paf-
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Release, purification, and characterization of platelet-activating factor (PAF)
Biochimie, 1980Platelet-activating factor (PAF) is a phospholipid mediator, released by basophils, macrophages and neutrophils under immunological and non immunological stimuli. It aggregates platelets and liberates their vasoactive contents. We studied the "spontaneous" release of PAF from hog blood leukocytes : optimal conditions were 22 degrees C, pH 9.5 in BSA ...
V, Tencé +3 more
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Aggregation of equine platelets by PAF (platelet-activating factor)
Inflammation, 1983Platelet-activating factor (PAF), a lipid released as a result of immediate allergic reactions from basophils and mast cells as well as by a variety of other cell types and stimuli, is one of the most potent platelet agonists and hypotensive agents known. Equine platelets stimulated over a wide range of PAF concentrations aggregated in a time- and dose-
C M, Suquet, R W, Leid
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