Results 241 to 250 of about 74,663 (286)

Structural analogs of platelet-activating factor (PAF-acether)

Biochimie, 1981
Platelet-activafing factor (PAF-acether) is a potent mediator of anaphylaxis and inflammation. It induces aggregation of platelets mad releases their vasoactive amines. PAF-acether has' been shown to be produced by basophils [1, 2], macrophages [3, 4], neutrophils [51, and platelets themselves [6].
M, Tence, E, Coeffier, F, Heymans, J, Polonsky, J J, Godfroid, J, Benveniste   +5 more
openaire   +2 more sources

Immunofluorescent localization of platelet-activating factor (PAF) in the rat

The Histochemical Journal, 1993
An immunofluorescent staining method for detecting platelet-activating factor (PAF) is described. This method employs a polyclonal anti-PAF rabbit antibody. When rat brain, heart, lung, liver or kidney tissue was stained using this method, the heart, lung and kidney exhibited PAF-specific staining.
Y, Hirashima, R, Kato, S, Endo, A, Takaku, K, Karasawa, S, Nojima   +5 more
openaire   +2 more sources

A specific, sensitive radioimmunoassay for platelet-activating factor (PAF)

Journal of Immunological Methods, 1990
A specific radioimmunoassay (RIA) has been developed for platelet-activating factor (PAF) and shown to be sensitive over the range 10-1000 pg (0.02-2 pmol). The anti-PAF antibodies showed specificity for the acetyl group at the C2 position of the PAF molecule and exhibited no significant cross-reactivity with lyso-PAF or the naturally occurring lipids ...
M A, Smal, B A, Baldo, A, McCaskill
openaire   +2 more sources

Plasma platelet activating factor-acetylhydrolase (PAF-AH)

Progress in Lipid Research, 2003
The platelet-activating factor-acetylhydrolase (PAF-AH) is an enzyme which catalyzes the hydrolysis of acetyl ester at the sn-2 position of PAF. The family of PAF-AHs consists of two intracellular isoforms (Ib and II), and one secreted isoform (plasma). These PAF-AHs show different biochemical characteristics and molecular structures. Plasma PAF-AH and
Ken, Karasawa, Ayako, Harada, Noriko, Satoh, Keizo, Inoue, Morio, Setaka   +4 more
openaire   +2 more sources

Platelet-activating factor (PAF) and PAF antagonists in asthma.

Critical reviews in therapeutic drug carrier systems, 1991
PAF is produced by and activates inflammatory cells, such as monocytes/macrophages, mast cells, platelets, neutrophils, eosinophils and endothelial cells. Its ability to imitate anaphylaxis, inducing for instance bronchoconstriction (BC) in guinea-pigs, and its identification (and/or that of lyso-PAF) in exudates from shocked lungs, led to the ...
D, Hosford, J M, Mencia-Huerta, P, Braquet   +2 more
openaire   +1 more source

Biological activity of Platelet Activating Factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF)

Biochemical and Biophysical Research Communications, 1985
A novel amidophosphonate analog of Platelet Activating Factor (PAF), trimethyl (3-phosphonopropyl) ammonium hydroxide (R)-mono[2-acetamido-3-(hexadecyloxy)propyl] ester (PAF-AP), was synthesized. A potent inhibitor of aggregation induced by Platelet Activating Factor, arachidonic acid, Ca2+-ionophore, ADP, and thrombin, PAF-AP had no or very little ...
M, Steiner, R, Landolfi, N C, Motola, J G, Turcotte   +3 more
openaire   +2 more sources

Platelet-activating factor (PAF-acether): Present status

Agents and Actions, 1981
PAF-acether, first discovered in 1971-72, is now recognized as a 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine released from various cells and organs, including macrophages, neutrophils, platelets, the kidney and heart. In this review, we will concentrate on the newest aspects of PAF-acether biochemistry and pathophysiology: (1) PAF-acether is ...
openaire   +2 more sources

Rabbit blastocysts accumulate platelet‐activating factor (PAF) and lyso‐PAF in vitro

Molecular Reproduction and Development, 1992
AbstractPlatelet‐activating factor (1‐O‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine; PAF) is a very potent phospholipid, which has been demonstrated to stimulate smooth muscle and change vascular permeability. PAF has been detected in the rabbit preimplantation uterine endometrium and has been demonstrated to bind specifically to rabbit uterine ...
M A, Jones, G B, Kudolo, M J, Harper
openaire   +2 more sources

The Role of Platelet-Activating Factor (PAF) in Experimental Glomerular Injury

Lipids, 1991
AbstractPlatelet‐activating factor (PAF) is a potent autacoid that participates in inflammation and other pathophysiological processes. In this review we deal with recent evidence suggesting that PAF is a mediator that is released early during glomerular injury. PAF can be synthesized in the glomerulus by infiltrating intrinsic glomerular cells. Normal
A, Ortiz, M, Gomez-Chiarri, J L, Lerma, E, Gonzalez, J, Egido   +4 more
openaire   +2 more sources

Molecular modeling on platelet‐activating factor (PAF) and new proposed PAF antagonists

International Journal of Quantum Chemistry, 1996
Platelet-activating factor (PAF) is an autacoid derived from cellular membrane phospholipids in response to chemical or physical stimuli. It has been identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine; the alkyl group is composed of 16 or 18 carbon atoms in human cells.
Carlos M. R. De Sant'anna, Ricardo Bicca De Alencastro, Carlos A. M. Fraga, Eliezer J. Barreiro, Joaquim Delphino Da Motta Neto   +4 more
openaire   +1 more source