Results 111 to 120 of about 158,362 (293)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia

Platelets
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined.
Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni   +18 more
doaj   +1 more source

Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy

BMC Cancer, 2010
Background Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating factor receptor (PAF-R)-mediated pathways. In the present study, we investigated the
Rohde Ciro BS, Pinheiro Mônica C, Fernandes Patrícia D, Nonogaki Sueli, Onuchic Ana C, Andrade Luciana NS, de Oliveira Soraya I, Chammas Roger, Jancar Sonia   +8 more
doaj   +1 more source

Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species

Molecules, 2010
Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G.
Juriyati Jalil, Fasihuddin bin Ahmad, Ibrahim Jantan, Bushra Abdulkarim Moharam   +3 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence. [PDF]

Front Pharmacol, 2022
Li T, Zhang X, Jiang P, Zhang D, Feng L, Lai X, Qin M, Wei Y, Zhang C, Gao Y.   +9 more
europepmc   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway. [PDF]

Cancers (Basel), 2021
Kawasaki K, Kasamatsu A, Ando T, Saito T, Nobuchi T, Nozaki R, Iyoda M, Uzawa K.   +7 more
europepmc   +1 more source