Results 91 to 100 of about 1,044,846 (392)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Identification of Platelet-Activating Factor Acetylhydrolase II in Human Skin [PDF]

, 2002
Platelet-activating factor acetylhydrolases are a family of specialized phospholipase A2 enzymes. They serve an anti-inflammatory function by converting the proinflammatory autocoid, PAF, into biologically inactive lyso-PAF, by the removal of the sn-2 ...
Aoki, Junken, Arai, Hiroyuki, Inoue, Takao, Johnston, John M., Marques, Mariangela, Pei, Yong, Seltmann, Holger, Southall, Michael D., Travers, Jeffrey B., Zouboulis, Christos C.   +9 more
core   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Contribution of the Platelet Factor V Content to Platelet Factor 3 Activity [PDF]

British Journal of Haematology, 1980
Summary. The procoagulant activity obtained from bovine thrombocytes has been compared to that of lipids isolated from platelets, with and without the addition of purified bovine factor V. A one‐stage assay, which consisted of delipidated bovine plasma containing RVV‐activated factor X, was used to assess the activity.
H. van Zutphen, Robert F. A. Zwaal, Edouard M. Bevers, H.C. Hemker   +3 more
openaire   +4 more sources

Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis

Journal of Lipid Research, 2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities.
Stefan Blankenberg, Dominique Stengel, Hans J. Rupprecht, Christoph Bickel, Ju¨rgen Meyer, François Cambien, Laurence Tiret, Ewa Ninio   +7 more
doaj  

Involvement of Platelet-Activating Factor in Ultraviolet B-Induced Hyperalgesia [PDF]

, 2009
Ultraviolet B (UVB) radiation causes cutaneous inflammation. One important clinical consequence of UVB-induced inflammation is increased pain or hyperalgesia, which is likely mediated by enhanced sensitivity of cutaneous sensory neurons. Previous studies
Al-Hassani, Mohammad, Cai, Shanbao, Hingtgen, Cynthia M., Pollok, Karen E., Sitzman, Leslie A., Travers, Jeffrey B., Zhang, Qiwei   +6 more
core   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.

Proceedings of the National Academy of Sciences of the United States of America, 1985
Platelet-activating factor (PAF) is a potent lipid mediator of inflammation and asthma. Using a receptor preparation of rabbit platelet membranes, we identified a novel antagonist of PAF in the methylene chloride extract of a Chinese herbal plant ...
T. Shen, S. Hwang, M. N. Chang, T. Doebber, M. Lam, M. Wu, X. Wang, G. Han, R. Li   +8 more
semanticscholar   +1 more source

Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells [PDF]

, 2015
UV radiation-induced systemic immune suppression is a major risk factor for skin cancer induction. The migration of dermal mast cells from the skin to the draining lymph nodes has a prominent role in activating systemic immune suppression.
Adcock, Albert, Aponte, Arya, Balasubramanyam, Bussolati, Butterfield, Byrne, Cameron, Chacón-Salinas, Chacón-Salinas, Cheung, Conte, Counts, Denizot, Denizot, Dy, Elisabetta Damiani, Enrique Gorbea, Feuerherm, Gong, Gray, Gul, Hart, Hildmann, Jones, Jones, Juremalm, Lehr, Li, Liu, Lorant, Ma, Marathe, Medzhitov, Mori, Nahum Puebla-Osorio, Pazin, Pei, Pitton, Prescott, Przybylski, Puebla-Osorio, Ramos, Rhee, Sahu, Sato, Shuto, Sreevidya, Stafforini, Stephen E. Ullrich, Suarez-Alvarez, Sullivan, Travers, Walterscheid, Yoshikawa   +55 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source