Results 81 to 90 of about 192,543 (284)

Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice

Redox Biology, 2013
Background: The biologically active phospholipids Platelet-activating Factor (PAF) and oxidatively truncated phospholipids from chemical oxidation are increased in the circulation of rats subject to the oxidant stress of chronic ethanol ingestion ...
Jinbo Liu, Wei Li, Rui Chen, Thomas M. McIntyre   +3 more
doaj   +1 more source

Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor [PDF]

, 2013
Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood.
Amatruda, Ames, Amie K. Waller, Brown, Christopher Kumar, Clark, Corrigan, Deo, Draing, Dupré, Fedtke, Fischer, Fitzgerald, Haribabu, Hashimoto, Hwang, Iwasaki, Jonathan M. Gibbins, Kengatharan, Li, Lotz, Madsen, Mazer, Miajlovic, Moraes, Morath, Murphy, Nick, Peschel, Que, Reichmann, Rowley, Schmaler, Schröder, Schwarz, Shannon, Sheu, Siboo, Simon R. Clarke, Smyth, Stoll, Tanya Sage, Thomas Carr, Travers, van Langevelde, Vinogradov, Vogensen, Voorhees, Weidenmaier, Weidenmaier, Ye, Yeaman, Youssefian, Yue, Zhang, Zhang   +55 more
core   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Ligation of protease-activated receptor 1 enhances alpha(v)beta(6) integrin-dependent TGF-beta activation and promotes acute lung injury [PDF]

, 2006
Activation of latent TGF-beta by the alpha(v)beta(6) integrin is a critical step in the development of acute lung injury. However, the mechanism by which a alpha(v)beta(6)-mediated TGF-beta activation is regulated has not been identified.
Camerer, E, Chambers, RC, Davis, GE, Jenkins, RG, Laurent, GJ, Matthay, MA, Scotton, CJ, Sheppard, D, Su, G, Su, X   +9 more
core  

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer-Lack of association between activating AKT mutation and AKT inhibition-derived efficacy [PDF]

, 2019
This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced ...
Boix, Oliver, Hess, Dagmar, Hurvitz, Sara A, Joerger, Markus, Lagkadinou, Eleni, Ma, Cynthia, Moulder, Stacy, Ocker, Matthias, Rentzsch, Christine, Rudolph, Marion, Schneeweiss, Andreas, Thiele, Silke, Tsimberidou, Apostolia M, Varga, Andrea, Wilkinson, Gary   +14 more
core   +3 more sources

Tuning the Dielectric Properties of Individual Clay Nanosheets by Interlayer Composition: Toward Nano‐Electret Materials

Advanced Functional Materials, EarlyView.
The dielectric properties of clays are studied on the level of individual monolayers and functional double stacks. The material breakdown characteristics and charge storage performance are analyzed. For illustration, a defined charge pattern representing a cuneiform character is produced, written into a microscopic clay tile, referencing the origins of
Sebastian Gödrich, Paul Markus, Matthias Stöter, Bernhard Biersack, Rainer Schobert, Josef Breu, Georg Papastavrou   +6 more
wiley   +1 more source

Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers[S]

Journal of Lipid Research, 2010
The conversion of lysophosphatidic acid (LPA) to phosphatidic acid is carried out by the microsomal enzymes 1-acylglycerol-3-phosphate-O-acyltransferases (AGPATs).
Anil K. Agarwal, Abhimanyu Garg
doaj   +1 more source

A Perspective of Coagulation Dysfunction in Multiple Sclerosis and in Experimental Allergic Encephalomyelitis [PDF]

, 2018
A key role of both coagulation and vascular thrombosis has been reported since the first descriptions of multiple sclerosis (MS). Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of ...
Adams, Adams, Akassoglou, Akassoglou, Akenami, Akenami, Albright, Alizadeh, Alonso, Amor, Antoniak, Beggs, Bidot, Bitsch, Boesen, Brkic, Bronstein, Brunetti, Castellino, Cesarman-Maus, Chapman, Chelmicka-Szorc, Claudio, Compston, Coughlin, Cuzner, Danø, Davalos, Davalos, Davidson, Davie, De Luca, Dekaban, Deschepper, Donovan, East, Ed Rainger, Engelmann, Esmon, Esmon, Fan, Fan, Farber, Feldman, Ferguson, Festoff, Field, Fiorini, Flick, Fog, Friedman, Garcia-Monco, García, Garg, Genc, Gloor, Griffin, Griffin, Guenther, Gveric, Göbel, Göbel, Göbel, Hafler, Han, Horstman, Huszak, Inaba, Inoue, Iong, Jacob, Jones, Kalaria, Kirichuk, Kirk, Kirk, Knauer, Koudriavtseva, Koudriavtseva, Koudriavtseva, Koudriavtseva, Kreutzberg, Kuhlmann, Kwon, Lane, Langer, Lassmann, Lassmann, Lassmann, Lesny, Liddelow, Lider, Lin, Lin, Lock, Lu, Mahmood, Mandoj, Marik, Mechelli, Miranda, Moll, Murray, Park, Parsons, Paterson, Perez, Persson, Persson, Petersen, Phillips, Pike, Plantone, Plumb, Putnam, Putnam, Rand, Reese, Reinhard, Roizin, Ryu, Ryu, Saberi, Savitky, Seeds, Seeds, Sheremata, Simón, Smith, Sobel, Soon, Sotnikov, Spadaro, Starossom, Starossom, Stavrou, Stolz, Teesalu, Tennent, Ugarova, Uzawa, van der Poll, Varga, Verrall, Wachowicz, Wakefield, Weisel, Whitlock, Wittinghofer, Wolter, Wright, Xue, Yadav, Yamaji, Yates, Yuksel, Zhang, Ziliotto, Zivadinov   +158 more
core   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

Advanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska, Yutong Luo, Ruyan Zhao, Jianjun Zhang, Mingchao Wang, Xinliang Feng, Eike Brunner, Stefan Kaskel   +7 more
wiley   +1 more source

Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress

Journal of Lipid Research, 2003
PAF-dependent transacetylase (TA) modifies the functions of platelet-activating factor (PAF), a potent inflammatory lipid, either by transferring the acetyl group from PAF to lysophospholipids (TAL activity), or to sphingosine (TAS activity) or by ...
Maria Luisa Balestrieri, Domenico Castaldo, Ciro Balestrieri, Lucio Quagliuolo, Alfonso Giovane, Luigi Servillo   +5 more
doaj   +1 more source