Results 61 to 70 of about 115,616 (306)

Differential regulation of formyl peptide and platelet-activating factor receptors: role of phospholipase Cbeta3 phosphorylation by protein kinase A

, 1998
Formylated peptides (e.g. n-formyl-Met-Leu-Phe (fMLP)) and platelet-activating factor (PAF) mediate chemotactic and cytotoxic responses in leukocytes through receptors coupled to G proteins that activate phospholipase C (PLC).
Ricardo M. Richardson, Ali, H., Barr, A.J., Bodduluri Haribabu, Silvano Sozzani, Ralph Snyderman, Haribabu, B., Fisher, I., Richardson, R.M., Ian Fisher, Sozzani, S., Snyderman, R., Hydar Ali, Alastair J. Barr   +13 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effect of safflower yellow on platelet activating factor mediated platelet activation in patients with coronary heart disease

Bangladesh Journal of Pharmacology, 2012
The platelet aggregation and 5-HT release by washed platelet from coronary heart disease patients following platelet activating factor (PAF) treatment were detected by turbidimetry and O-phthalaldehyde assay.
Damin Huang, Yingmin Lu, Xiaohan Luo, Laixin Shi, Jinchun Zhang, Junxian Shen, Minmin Bao, Lei Song, Caiwen Wei, Hongsong Li, Zhihua Li   +10 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Novel chemo-enzymatic synthesis of optically active platelet activating factor

, 1993
This paper describes an enantioselective enzymatic synthesis of biologically active platelet activating factor (PAF) starting from chloropyruvic acid.
Bhakuni, Vinod, Kumar, Atul, Atul Kumar, Vinod Bhakuni   +3 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation

Journal of Lipid Research, 2005
Oxidation of LDL is thought to be involved in both initiating and sustaining atherogenesis through the formation of proinflammatory lipids and the covalent modification of LDL particles.
Nicolaos Androulakis, Hervé Durand, Ewa Ninio, Demokritos C. Tsoukatos   +3 more
doaj   +1 more source

The platelet-activating factor acetylhydrolase of mouse platelets

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997
Platelet-activating factor (PAF) acetylhydrolases are a family of distinct enzymes with the common property of hydrolyzing and inactivating PAF. It has been shown that the structure and the biochemical behavior of these enzymes depend on their cellular origin.
Karpouza, Angeliki P, Vakirtzi-Lemonias, Catherine   +1 more
openaire   +2 more sources

Platelet adhesion in atherogenesis [PDF]

, 2010
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Master of PhilosophyPlatelets are known to play a key role in acute coronary events, such as myocardial infarction, associated with advanced
Watkins, Jennifer
core  

Platelet-activating factor concentrations in healthy and septic neonates

, 1999
Platelet-activating factor levels were measured in nine preterm infants with Klebsiella pneumonia septicaemia, eight healthy preterm infants of similar gestational age and ten healthy full-term infants of the same postnatal age at sampling.
Kultursay, N, Kantar, M, Coker, I, Akisu, M, Huseyinov, A   +4 more
core   +1 more source