Results 51 to 60 of about 1,166,887 (302)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.

European Journal of Pharmacology, 1980
Platelet-activating factor (PAF-acether) is a phospholipid derivative released from stimulated basophils, macrophages and platelets. It induced the release of ATP from, and aggregated guinea-pig platelets.
B. Vargaftig, J. Lefort, M. Chignard, Jacques Benveniste   +3 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity

Journal of Lipid Research, 2003
The platelet-activating factor acetylhydrolase activity associated with high density lipoprotein (HDL-PAF-AH) may substantially contribute to the antioxidant, anti-inflammatory, and overall antiatherogenic effects of HDL.
Anna I. Kakafika, Stavroula Xenofontos, Vasilis Tsimihodimos, Afroditi P. Tambaki, Evangelia S. Lourida, Rigas Kalaitzidis, Marios A. Cariolou, Moses Elisaf, Alexandros D. Tselepis   +8 more
doaj   +1 more source

Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells

Frontiers in Genetics, 2021
Lipid species are known to have various biological functions owing to their structural differences, and each of them possesses a specific role to play depending upon their location and distribution in the cell. Some of these lipids interact with proteins
Vaishali Chakravarty, Libi Anandi, K. A. Ashiq, K. Abhijith, Rintu Umesh, Mayurika Lahiri   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Perbedaan Kadar Platelet Activating Factor Plasma antara Penderita Demam Berdarah Dengue dan Demam Dengue

Majalah Kedokteran Bandung, 2013
Dengue virus infection can manifest as dengue fever and, more severely, as dengue hemorrhagic fever. Their pathogenesis until now is not fully understood.
Djatnika Setiabudi, Budi Setiabudiawan, Ida Parwati, Herry Garna   +3 more
doaj   +1 more source

Specific binding of phospholipid platelet-activating factor by human platelets.

Journal of Immunology, 1982
The binding of the phospholipid platelet-activating factor 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC) to washed human platelets was more than 80% complete within 2 min, which coincided with the time of initiation of platelet ...
F. Valone, E. Coles, V. R. Reinhold, E. Goetzl   +3 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Food-specific serum IgG and symptom reduction with a personalized, unrestricted-calorie diet of six weeks in Irritable Bowel Syndrome (IBS)

Nutrition & Metabolism, 2020
Background Irritable Bowel Syndrome (IBS) is a widespread disease with variable symptoms that have an important impact on the quality of life. Despite the prevalence of IBS, its etiology and pathophysiology are still to be fully understood, but immune ...
Mattia Cappelletti, Emiliana Tognon, Linda Vona, Katia Basello, Andrea Costanzi, Michela Carola Speciani, Attilio Francesco Speciani   +6 more
doaj   +1 more source