Oxidized Phospholipids in Healthy and Diseased Lung Endothelium [PDF]
Cells, 2020 Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on the
Konstantin G Birukov
exaly +5 more sources
Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids [PDF]
Frontiers in Endocrinology, 2021 Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells.
Marco Di Gioia, Ivan Zanoni, Ivan Zanoni
doaj +3 more sources
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice [PDF]
Nature, 2018 Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes 1 .
Xuchu Que, Ming-Yow Hung, Calvin Yeang
exaly +4 more sources
Toxicity of oxidized phospholipids in cultured macrophages [PDF]
Lipids in Health and Disease, 2012 Background The interactions of oxidized low-density lipoprotein (LDL) and macrophages are hallmarks in the development of atherosclerosis. The biological activities of the modified particle in these cells are due to the content of lipid oxidation ...
Stemmer Ute +8 more
doaj +9 more sources
Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation [PDF]
Journal of Lipid Research, 2022 We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation.
Pallavi Mukherjee +11 more
doaj +3 more sources
Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed chromatin DNA and contents of granules, such as myeloperoxidase (MPO) and neutrophil elastase (NE).
Takuto Tokuhiro +16 more
doaj +3 more sources
Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy [PDF]
Cells, 2021 Oxidized phospholipids are well known to play physiological and pathological roles in regulating cellular homeostasis and disease progression. However, their role in cancer metastasis has not been entirely understood.
Jin Kyung Seok +9 more
doaj +3 more sources
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis [PDF]
Cell Metabolism, 2020 Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. Here, we show that OxPLs accumulate in human and mouse NASH.
Xiaoli Sun, Jason S Seidman, Peng Zhao
exaly +3 more sources
Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes. [PDF]
J Am Coll Cardiol, 2023 BACKGROUND Lipoprotein(a) (Lp[a]) and oxidized phospholipids (OxPLs) are each independent risk factors for atherosclerotic cardiovascular disease. The extent to which Lp(a) and OxPLs predict coronary artery disease (CAD) severity and outcomes in a ...
Gilliland TC +12 more
europepmc +2 more sources
Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. [PDF]
Aging Cell, 2021 Oxidized phospholipids (OxPLs) are pro‐inflammatory molecules that affect bone remodeling under physiological conditions. Transgenic expression of a single‐chain variable fragment (scFv) of the antigen‐binding domain of E06, an IgM natural antibody that ...
Palmieri M +10 more
europepmc +2 more sources