Oxidized Phospholipids in Healthy and Diseased Lung Endothelium [PDF]
Cells, 2020 Circulating and cell membrane phospholipids undergo oxidation caused by enzymatic and non-enzymatic mechanisms. As a result, a diverse group of bioactive oxidized phospholipids generated in these conditions have both beneficial and harmful effects on the
Konstantin G Birukov
exaly +5 more sources
Toxicity of oxidized phospholipids in cultured macrophages [PDF]
Lipids in Health and Disease, 2012 Background The interactions of oxidized low-density lipoprotein (LDL) and macrophages are hallmarks in the development of atherosclerosis. The biological activities of the modified particle in these cells are due to the content of lipid oxidation ...
Stemmer Ute +8 more
doaj +6 more sources
Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives [PDF]
Frontiers in Endocrinology, 2021 Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons
Beatrice Oehler +5 more
doaj +3 more sources
Simplified synthesis of oxidized phospholipids on alkyl-amide scaffold [PDF]
MethodsXOxidized phospholipids (OxPLs), containing oxidized fatty acids (oxylipins), play a significant role in various diseases. However, studying the structure-activity relationships of OxPLs and their signaling mechanisms is challenging due to the complexity ...
Olga V. Oskolkova +2 more
doaj +2 more sources
Dooming Phagocyte Responses: Inflammatory Effects of Endogenous Oxidized Phospholipids [PDF]
Frontiers in Endocrinology, 2021 Endogenous oxidized phospholipids are produced during tissue stress and are responsible for sustaining inflammatory responses in immune as well as non-immune cells.
Marco Di Gioia, Ivan Zanoni, Ivan Zanoni
doaj +2 more sources
The role of oxidized phospholipids in atherosclerosis
Journal of Lipid Research, 2009 There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions.
Judith A. Berliner +2 more
doaj +3 more sources
Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation [PDF]
Journal of Lipid Research, 2022 We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation.
Pallavi Mukherjee +11 more
doaj +2 more sources
Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed chromatin DNA and contents of granules, such as myeloperoxidase (MPO) and neutrophil elastase (NE).
Takuto Tokuhiro +16 more
doaj +2 more sources
Impact of Oxidized Phospholipids on Outcomes from Cerebral Ischemia and Reperfusion Injury [PDF]
PharmaceuticsBackground/Objectives: The mechanisms leading to oxidative stress and cellular dysfunction during stroke are not well understood. Methods: We tested if transient cerebral artery occlusion (MCAo) in mice results in the generation of oxidized phospholipids
Jin Yu +5 more
doaj +2 more sources
Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells [PDF]
Antioxidants, 2022 Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly ...
Christina Mauerhofer +10 more
doaj +2 more sources