Results 21 to 30 of about 203,353 (285)

Chemistry of phospholipid oxidation

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The oxidation of lipids has long been a topic of interest in biological and food sciences, and the fundamental principles of non-enzymatic free radical attack on phospholipids are well established, although questions about detail of the mechanisms remain.
Reis, Ana, Spickett, Corinne M.
openaire   +2 more sources

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice

Journal of Lipid Research, 2002
We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)−/− and LDL receptor (LDLr)−/− mice ...
Trudy M. Forte, Ganesamoorthy Subbanagounder, Judith A. Berliner, Patricia J. Blanche, Anne O. Clermont, Zhen Jia, Michael N. Oda, Ronald M. Krauss, John K. Bielicki   +8 more
doaj   +1 more source

Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase

Journal of Lipid Research, 2006
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils, an initiating event in atherogenesis. Here, we investigate intracellular signaling events induced by oxidized phospholipids in human umbilical vein endothelial ...
Joakim Huber, Alexander Fuärnkranz, Valery N. Bochkov, Mary K. Patricia, Hans Lee, Catherine C. Hedrick, Judith A. Berliner, Bernd R. Binder, Norbert Leitinger   +8 more
doaj   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Journal of Lipid Research, 2004
For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result from ...
Mohamad Navab, G.M. Ananthramaiah, Srinivasa T. Reddy, Brian J. Van Lenten, Benjamin J. Ansell, Gregg C. Fonarow, Kambiz Vahabzadeh, Susan Hama, Greg Hough, Naeimeh Kamranpour, Judith A. Berliner, Aldons J. Lusis, Alan M. Fogelman   +12 more
doaj   +1 more source

The Biosynthesis of Enzymatically Oxidized Lipids

Frontiers in Endocrinology, 2020
Enzymatically oxidized lipids are a specific group of biomolecules that function as key signaling mediators and hormones, regulating various cellular and physiological processes from metabolism and cell death to inflammation and the immune response. They
Ali A. Hajeyah, William J. Griffiths, Yuqin Wang, Andrew J. Finch, Valerie B. O’Donnell   +4 more
doaj   +1 more source

Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids

Journal of Lipid Research, 2010
Epidemiological evidence suggests that cardiovascular disease is associated with osteoporosis, independent of age. Bone resorptive surface is increased in mice on a high-fat diet, and osteoclastic differentiation of bone marrow preosteoclasts is promoted
Wendy Tseng, Jinxiu Lu, Gail A. Bishop, Andrew D. Watson, Andrew P. Sage, Linda Demer, Yin Tintut   +6 more
doaj   +1 more source

Oxidized phospholipids are ligands for LRP6 [PDF]

Bone Research, 2018
AbstractLow-density lipoprotein receptor–related protein 6 (LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular signaling activation. The ligands that bind directly to LRP6 have not been identified.
Wang, Lei, Chai, Yu, Li, Changjun, Liu, Haiyun, Su, Weiping, Liu, Xiaonan, Yu, Bing, Lei, Weiqi, Yu, Bin, Crane, Janet L., Cao, Xu, Wan, Mei   +11 more
openaire   +2 more sources

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Nature Communications, 2018
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism ...
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes   +31 more
doaj   +1 more source