Results 21 to 30 of about 655,979 (316)

Impact of Oxidized Phospholipids on Outcomes from Cerebral Ischemia and Reperfusion Injury [PDF]

Pharmaceutics
Background/Objectives: The mechanisms leading to oxidative stress and cellular dysfunction during stroke are not well understood. Methods: We tested if transient cerebral artery occlusion (MCAo) in mice results in the generation of oxidized phospholipids
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Cheryl Kirstein, Mark S. Kindy   +5 more
doaj   +2 more sources

Oxidized phospholipids are ligands for LRP6 [PDF]

Bone Research, 2018
Low-density lipoprotein receptor–related protein 6 (LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular signaling activation.
Lei Wang, Yu Chai, Changjun Li, Haiyun Liu, Weiping Su, Xiaonan Liu, Bingfang Yu, Weiqi Lei, Bin Yu, Janet L. Crane, Xu Cao, M. Wan   +11 more
semanticscholar   +3 more sources

PCSK9 Inhibition and Oxidized Phospholipids. [PDF]

J Am Coll Cardiol, 2021
Bhatia HS, Yeang C, Baruch A, Yang X, Stroes ESG, Tsimikas S.   +5 more
europepmc   +2 more sources

Protein targets of oxidized phospholipids in endothelial cellss⃞ [PDF]

Journal of Lipid Research, 2008
Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (Ox-PAPC) are found in atherosclerotic lesions, apoptotic cells, and oxidized LDL and stimulate human aortic endothelial cells (HAECs) to produce inflammatory cytokines ...
B. Gabriel Gugiu, Kevin Mouillesseaux, Victoria Duong, Tabitha Herzog, Avetis Hekimian, Lukasz Koroniak, Thomas M. Vondriska, Andrew D. Watson   +7 more
doaj   +3 more sources

Evaluation of antioxidant property of heat shock protein 90 from duck muscle [PDF]

Animal Bioscience, 2021
Objective The objectives of this study were to investigate the direct antioxidative effect of 90 Kda heat shock protein (Hsp90) obtained from duck muscle.
Muhan Zhang, Daoying Wang, Xinglian Xu, Weimin Xu   +3 more
doaj   +1 more source

Oxidized phospholipids are biomarkers, drug targets, and drug leads

Frontiers in Drug Discovery, 2022
Enzymatic oxidation or autooxidation of esterified polyunsaturated fatty acids (PUFA) residues within phospholipids in cell membranes or circulating lipoprotein particles leads to the formation of a broad range of oxidized phospholipid (OxPL) species ...
O. Oskolkova, A. Birukova, K. Birukov, V. Bochkov   +3 more
semanticscholar   +1 more source

In Vitro Digestion of Grape Seed Oil Inhibits Phospholipid-Regulating Effects of Oxidized Lipids

Biomolecules, 2020
The intake of dietary lipids is known to affect the composition of phospholipids in gastrointestinal cells, thereby influencing passive lipid absorption.
Sarah Fruehwirth, Sofie Zehentner, Mohammed Salim, Sonja Sterneder, Johanna Tiroch, Barbara Lieder, Martin Zehl, Veronika Somoza, Marc Pignitter   +8 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice

Journal of Lipid Research, 2002
We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)−/− and LDL receptor (LDLr)−/− mice ...
Trudy M. Forte, Ganesamoorthy Subbanagounder, Judith A. Berliner, Patricia J. Blanche, Anne O. Clermont, Zhen Jia, Michael N. Oda, Ronald M. Krauss, John K. Bielicki   +8 more
doaj   +1 more source

Chemistry of phospholipid oxidation

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The oxidation of lipids has long been a topic of interest in biological and food sciences, and the fundamental principles of non-enzymatic free radical attack on phospholipids are well established, although questions about detail of the mechanisms remain.
Reis, Ana, Spickett, Corinne M.
openaire   +2 more sources