Results 31 to 40 of about 655,979 (316)

Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase

Journal of Lipid Research, 2006
Oxidized phospholipids stimulate endothelial cells to bind monocytes, but not neutrophils, an initiating event in atherogenesis. Here, we investigate intracellular signaling events induced by oxidized phospholipids in human umbilical vein endothelial ...
Joakim Huber, Alexander Fuärnkranz, Valery N. Bochkov, Mary K. Patricia, Hans Lee, Catherine C. Hedrick, Judith A. Berliner, Bernd R. Binder, Norbert Leitinger   +8 more
doaj   +1 more source

The Biosynthesis of Enzymatically Oxidized Lipids

Frontiers in Endocrinology, 2020
Enzymatically oxidized lipids are a specific group of biomolecules that function as key signaling mediators and hormones, regulating various cellular and physiological processes from metabolism and cell death to inflammation and the immune response. They
Ali A. Hajeyah, William J. Griffiths, Yuqin Wang, Andrew J. Finch, Valerie B. O’Donnell   +4 more
doaj   +1 more source

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Journal of Lipid Research, 2004
For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result from ...
Mohamad Navab, G.M. Ananthramaiah, Srinivasa T. Reddy, Brian J. Van Lenten, Benjamin J. Ansell, Gregg C. Fonarow, Kambiz Vahabzadeh, Susan Hama, Greg Hough, Naeimeh Kamranpour, Judith A. Berliner, Aldons J. Lusis, Alan M. Fogelman   +12 more
doaj   +1 more source

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]

, 2011
Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia, Garg, Abhishek D, Krysko, Dmitri, Vandenabeele, Peter   +3 more
core   +1 more source

Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids

Journal of Lipid Research, 2010
Epidemiological evidence suggests that cardiovascular disease is associated with osteoporosis, independent of age. Bone resorptive surface is increased in mice on a high-fat diet, and osteoclastic differentiation of bone marrow preosteoclasts is promoted
Wendy Tseng, Jinxiu Lu, Gail A. Bishop, Andrew D. Watson, Andrew P. Sage, Linda Demer, Yin Tintut   +6 more
doaj   +1 more source

Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis

Journal of the American College of Cardiology, 2019
Background Lipoprotein(a) [Lp(a)], a major carrier of oxidized phospholipids (OxPL), is associated with an increased incidence of aortic stenosis (AS).
K. Zheng, S. Tsimikas, T. Pawade, J. Kroon, W. Jenkins, M. Doris, A. White, N. Timmers, J. Hjortnaes, M. Rogers, E. Aikawa, B. Arsenault, J. Witztum, D. Newby, M. Koschinsky, Z. Fayad, Erik S. G. Stroes, S. Boekholdt, M. Dweck   +18 more
semanticscholar   +1 more source

Identification of short-chain oxidized phosphatidylcholine in human plasma

Journal of Lipid Research, 1996
Oxidized phospholipids have been recognized as potentially important compounds that carry biological activities similar to the platelet-activating factor, but their presence in biological tissue has not been firmly established.
M Schlame, R Haupt, I Wiswedel, W J Kox, B Rüstow   +4 more
doaj   +1 more source

Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System [PDF]

, 2010
Oxidative stresses from irritants such as hydrogen peroxide and ozone (O_3) can cause dysfunction of the pulmonary surfactant (PS) layer in the human lung, resulting in chronic diseases of the respiratory tract.
Beauchamp, J. L., Beegle, Luther W., Goddard, William A., III, Heath, James R., Jang, Seung Soon, Kanik, Isik, Kim, Hugh I., Kim, Hyungjun, Neidholdt, Evan L., Shin, Young Shik   +9 more
core   +2 more sources

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]

, 2017
Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P, Hammock, Bruce D, Hennebelle, Marie, Kitson, Alex P, Lee, Kin Sing Stephen, Metherel, Adam H, Otoki, Yurika, Richardson, Christine E, Taha, Ameer Y, Yang, Jun, Zhang, Liang, Zhang, Zhichao   +11 more
core   +1 more source

Proliferative glioblastoma cancer cells exhibit persisting temporal control of metabolism and display differential temporal drug susceptibility in chemotherapy [PDF]

, 2019
Even in immortalized cell lines, circadian clocks regulate physiological processes in a time-dependent manner, driving transcriptional and metabolic rhythms, the latter being able to persist without transcription.
Gaveglio, Virginia Lucía, Gorne, Lucas Damián, Guido, Mario Eduardo, Pasquaré, Susana Juana, Salvador, Gabriela Alejandra, Sosa Alderete, Lucas Gastón, Wagner, Paula Micaela   +6 more
core   +1 more source