Results 31 to 40 of about 203,353 (285)
Identification of short-chain oxidized phosphatidylcholine in human plasma
Journal of Lipid Research, 1996 Oxidized phospholipids have been recognized as potentially important compounds that carry biological activities similar to the platelet-activating factor, but their presence in biological tissue has not been firmly established.
M Schlame +4 more
doaj +1 more source
Mixing of oxidized and bilayer phospholipids
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015 Composition and phase dependence of the mixing of 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), with the oxidized phospholipid, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) were investigated by characterizing the aggregation states of DPPC/PGPC and DOPC/PGPC using a fluorescence ...
Singh, Jasmeet, Ranganathan, Radha
openaire +2 more sources
Protein targets of oxidized phospholipids in endothelial cellss⃞
Journal of Lipid Research, 2008 Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (Ox-PAPC) are found in atherosclerotic lesions, apoptotic cells, and oxidized LDL and stimulate human aortic endothelial cells (HAECs) to produce inflammatory cytokines ...
B. Gabriel Gugiu +7 more
doaj +1 more source
Oxidized Phospholipids as Potential Novel Drug Targets [PDF]
, 2007 The interactions of three therapeutic agents, viz. the antipsychotics HPD and CPZ, and the antineoplastic anthracycline DOX, with oxidatively modified phospholipids were studied by monitoring the quenching of fluorescence of an incorporated pyrene ...
Sabatini, Karen +2 more
core +1 more source
Journal of Lipid Research, 2000 Previous studies have shown that macrophage receptors for oxidized LDL (OxLDL) recognize both the lipid and protein moieties, and that a monoclonal antibody against OxLDL, EO6, also recognizes both species.
Kristin L. Gillotte +3 more
doaj +1 more source
Journal of Lipid Research, 2012 Cholesterol is an essential component of eukaryotic cell membranes, regulating fluidity and permeability of the bilayer. Outside the membrane, cholesterol is esterified to fatty acids forming cholesterol esters (CEs).
Patrick M. Hutchins, Robert C. Murphy
doaj +1 more source
Phospholipid Membrane Transport and Associated Diseases
Biomedicines, 2022 Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized ...
Raúl Ventura +2 more
doaj +1 more source
Oxidized phospholipid damage signals as modulators of immunity
Open BiologyDamage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, become oxidized under conditions of cellular stress ...
Joon H. Choi, Jonathan C. Kagan
doaj +1 more source
A novel role for 12/15-lipoxygenase in regulating autophagy
Redox Biology, 2015 12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material ...
Alwena H. Morgan +8 more
doaj +1 more source
Oxidized phospholipids: From molecular properties to disease [PDF]
, 2007 Oxidized lipids are generated from (poly)unsaturated diacyl- and alk(en)ylacyl glycerophospholipids under conditions of oxidative stress. The great variety of reaction products is defined by the degree of modification, hydrophobicity, chemical reactivity,
Hermetter, Albin +3 more
core +1 more source