Results 11 to 20 of about 655,979 (316)

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. [PDF]

Circulation, 2021
Supplemental Digital Content is available in the text. Background: LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors.
Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR.   +19 more
europepmc   +2 more sources

Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study. [PDF]

J Am Heart Assoc
Background Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease and valvular heart disease.
Januzzi JL, van Kimmenade RRJ, Liu Y, Hu X, Browne A, Plutzky J, Tsimikas S, Blankstein R, Natarajan P.   +8 more
europepmc   +2 more sources

Simplified synthesis of oxidized phospholipids on alkyl-amide scaffold [PDF]

MethodsX
Oxidized phospholipids (OxPLs), containing oxidized fatty acids (oxylipins), play a significant role in various diseases. However, studying the structure-activity relationships of OxPLs and their signaling mechanisms is challenging due to the complexity ...
Olga V. Oskolkova, Bernd Gesslbauer, Valery Bochkov   +2 more
doaj   +2 more sources

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Nature Communications, 2018
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism ...
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes   +31 more
doaj   +2 more sources

The role of oxidized phospholipids in atherosclerosis

Journal of Lipid Research, 2009
There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions.
Judith A. Berliner, Norbert Leitinger, Sotirios Tsimikas   +2 more
doaj   +3 more sources

Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives [PDF]

Frontiers in Endocrinology, 2021
Within the lipidome oxidized phospholipids (OxPL) form a class of chemically highly reactive metabolites. OxPL are acutely produced in inflamed tissue and act as endogenous, proalgesic (pain-inducing) metabolites. They excite sensory, nociceptive neurons
Beatrice Oehler, Beatrice Oehler, Beatrice Oehler, Alexander Brack, Robert Blum, Heike L. Rittner   +5 more
doaj   +2 more sources

Low Concentrations of Oxidized Phospholipids Increase Stress Tolerance of Endothelial Cells [PDF]

Antioxidants, 2022
Oxidized phospholipids (OxPLs) are generated by enzymatic or autooxidation of esterified polyunsaturated fatty acids (PUFAs) residues. OxPLs are present in circulation and atherosclerotic plaques where they are thought to induce predominantly ...
Christina Mauerhofer, Taras Afonyushkin, Olga V. Oskolkova, Klara Hellauer, Bernd Gesslbauer, Jasmin Schmerda, Yunbo Ke, Andreas Zimmer, Anna A. Birukova, Konstantin G. Birukov, Valery Bochkov   +10 more
doaj   +2 more sources

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. [PDF]

Nat Immunol, 2020
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-
Di Gioia M, Spreafico R, Springstead JR, Mendelson MM, Joehanes R, Levy D, Zanoni I.   +6 more
europepmc   +2 more sources

Associations between lipoprotein(a), oxidized phospholipids, and extracoronary vascular disease [PDF]

Journal of Lipid Research
The roles of lipoprotein(a) [Lp(a)] and related oxidized phospholipids (OxPLs) in the development and progression of coronary disease is known, but their influence on extracoronary vascular disease is not well-established.
Tiffany R. Bellomo, Yuxi Liu, Thomas C. Gilliland, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi, Jr., Pradeep Natarajan   +12 more
doaj   +2 more sources

Pleiotropic effects of oxidized phospholipids.

Free Radical Biology and Medicine, 2017
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and ...
V. Bochkov, Bernd Gesslbauer, Christina Mauerhofer, M. Philippova, P. Erne, O. Oskolkova   +5 more
semanticscholar   +4 more sources