Oxidized phospholipid damage signals as modulators of immunity [PDF]
Open BiologyDamage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, become oxidized under conditions of cellular stress ...
Joon H. Choi, Jonathan C. Kagan
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Oxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury [PDF]
Scientific ReportsE-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures,
Tomeka L. Suber +24 more
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NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions [PDF]
Frontiers in Molecular Neuroscience, 2018 Oxidized phospholipids (OxPL) like oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) were recently identified as novel proalgesic targets in acute and chronic inflammatory pain.
Corinna Martin +10 more
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The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3 [PDF]
Journal of Lipid ResearchFerroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis.
Si Chen +13 more
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Protein targets of oxidized phospholipids in endothelial cellss⃞ [PDF]
Journal of Lipid Research, 2008 Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (Ox-PAPC) are found in atherosclerotic lesions, apoptotic cells, and oxidized LDL and stimulate human aortic endothelial cells (HAECs) to produce inflammatory cytokines ...
B. Gabriel Gugiu +7 more
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Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors [PDF]
Journal of Lipid Research, 2000 Previous studies have shown that macrophage receptors for oxidized LDL (OxLDL) recognize both the lipid and protein moieties, and that a monoclonal antibody against OxLDL, EO6, also recognizes both species.
Kristin L. Gillotte +3 more
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CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid [PDF]
Respiratory Research, 2023 Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibrosis.
Doyun Kwak +7 more
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Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine [PDF]
Journal of Lipid Research, 2000 Plasmenyl phospholipids are a structurally unique class of lipids that contain a vinyl ether substituent at the sn-1 position of the glycerol backbone, imparting unique susceptibility to oxidative reactions that may take place at the cell membrane lipid ...
Nona Khaselev, Robert C. Murphy
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Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation [PDF]
Scientific Reports, 2017 Phospholipids occurring in cell membranes and lipoproteins are converted into oxidized phospholipids (OxPL) by oxidative stress promoting atherosclerotic plaque formation.
Beatrice Oehler +17 more
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Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE
Redox Biology, 2022 Phospholipid peroxidation of polyunsaturated fatty acids at the bis-allylic position drives ferroptosis. Here we identify a novel role for phospholipid peroxidation in the inhibition of autophagy.
Wen Li +18 more
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