Results 31 to 40 of about 63,046 (336)

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]

, 2016
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana, Gibson Dilthey, Beverly, Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Kovacs, Attila, Liu, Xinping, Mancuso, David J, Moon, Sung Ho, Nguyen, Annie L, Sims, Harold F, Weinheimer, Carla J, Yang, Kui   +12 more
core   +2 more sources

Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease

Frontiers in Cell and Developmental Biology, 2022
Calcified aortic valve disease (CAVD) is the most common valvular cardiovascular disease with increasing incidence and mortality. The primary treatment for CAVD is surgical or transcatheter aortic valve replacement and there remains a lack of effective ...
Jiahui Hu, Jiahui Hu, Jiahui Hu, Jiahui Hu, Hao Lei, Hao Lei, Hao Lei, Hao Lei, Leiling Liu, Leiling Liu, Leiling Liu, Leiling Liu, Danyan Xu, Danyan Xu, Danyan Xu, Danyan Xu   +15 more
doaj   +1 more source

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. [PDF]

, 2018
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes 1 .
Binder, Christoph J, Bowden, Karen, Diehl, Cody, Gaddis, Dalia E, Glass, Christopher K, Gonen, Ayelet, Hedrick, Catherine C, Hung, Ming-Yow, Ley, Klaus, MacDonald, Jeffrey G, Mellon, Pamela L, Miller, Yury I, Määttä, Antti, Pattison, Jennifer, Peterson, Kirk L, Prohaska, Thomas A, Que, Xuchu, Sun, Xiaoli, Tsimikas, Sotirios, Witztum, Joseph L, Yeang, Calvin, Ylä-Herttuala, Seppo   +21 more
core   +1 more source

Characterization of a specific polyclonal antibody against 13-hydroperoxyoctadecadienoic acid-modified protein: formation of lipid hydroperoxide-modified apoB-100 in oxidized LDL

Journal of Lipid Research, 1997
Lipid hydroperoxide may react with protein or amino phospholipid without secondary decomposition. We prepared a polyclonal antibody to lipid hydroperoxide-modified proteins using 13S-hydroperoxy-9Z, 11E-octadecadienoic acid-modified keyhole limpet ...
Y Kato, Y Makino, T Osawa
doaj   +1 more source

Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation

Frontiers in Cell and Developmental Biology, 2021
Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed chromatin DNA and contents of granules, such as myeloperoxidase (MPO) and neutrophil elastase (NE).
Takuto Tokuhiro, Akane Ishikawa, Haruka Sato, Shunya Takita, Ayuri Yoshikawa, Ryoko Anzai, Shinichi Sato, Ryohei Aoyagi, Ryohei Aoyagi, Makoto Arita, Makoto Arita, Makoto Arita, Takumi Shibuya, Yasuaki Aratani, Shigeomi Shimizu, Masato Tanaka, Satoshi Yotsumoto   +16 more
doaj   +1 more source

Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: Results from a randomized clinical trial [PDF]

, 1998
Background/Aim: Previous studies in vitro and in animals in vivo found that alpha-linolenic acid (C18:3 omega 3) may enhance oxidative damage of essential amino acids.
Burus, I., Decsi, Tamás, Koletzko, Berthold   +2 more
core   +1 more source

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

The role of oxidized phospholipids in atherosclerosis

Journal of Lipid Research, 2009
There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in atherosclerosis. These phospholipids accumulate in human and mouse lesions. Specific OxPLs have been identified as major regulators of many cell types present in the vessel wall. In endothelial cells, >1,000 genes are regulated.
Judith A. Berliner, Norbert Leitinger, Sotirios Tsimikas   +2 more
openaire   +3 more sources

Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules

Lipids in Health and Disease, 2004
Introduction Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have role in pathogenesis of malaria.
Looareesuwan Sornchai, Brittenham Gary, Leowattana Wattana, Krudsood Srivicha, Yamanont Paveena, Sibmooh Nathawut, Udomsangpetch Rachanee   +6 more
doaj   +1 more source

A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

eLife, 2021
Oxidized phospholipids have diverse biological activities, many of which can be pathological, yet how they are inactivated in vivo is not fully understood.
Benkun Zou, Michael Goodwin, Danial Saleem, Wei Jiang, Jianguo Tang, Yiwei Chu, Robert S Munford, Mingfang Lu   +7 more
doaj   +1 more source