Results 21 to 30 of about 63,046 (336)

Phospholipid Membrane Transport and Associated Diseases

Biomedicines, 2022
Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized ...
Raúl Ventura, Inma Martínez-Ruiz, María Isabel Hernández-Alvarez   +2 more
doaj   +1 more source

The Skin Epilipidome in Stress, Aging, and Inflammation

Frontiers in Endocrinology, 2021
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber, Florian Gruber, Florian Gruber, Martina Marchetti-Deschmann, Martina Marchetti-Deschmann, Christopher Kremslehner, Christopher Kremslehner, Christopher Kremslehner, Markus Schosserer, Markus Schosserer, Markus Schosserer   +10 more
doaj   +1 more source

Oxidized phospholipids are ligands for LRP6 [PDF]

Bone Research, 2018
AbstractLow-density lipoprotein receptor–related protein 6 (LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular signaling activation. The ligands that bind directly to LRP6 have not been identified.
Wang, Lei, Chai, Yu, Li, Changjun, Liu, Haiyun, Su, Weiping, Liu, Xiaonan, Yu, Bing, Lei, Weiqi, Yu, Bin, Crane, Janet L., Cao, Xu, Wan, Mei   +11 more
openaire   +2 more sources

A novel role for 12/15-lipoxygenase in regulating autophagy

Redox Biology, 2015
12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material ...
Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell   +8 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

ApoE−/−Fas−/− C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia

Journal of Lipid Research, 2007
To establish a mouse model of accelerated atherosclerosis in lupus, we generated apolipoprotein E-deficient (apoE−/−) and Faslpr/lpr (Fas−/−) C57BL/6 mice.
Xuebing Feng, Hongyun Li, Alexis A. Rumbin, Xuping Wang, Antonio La Cava, Katherine Brechtelsbauer, Lawrence W. Castellani, Joseph L. Witztum, Aldons J. Lusis, Betty P. Tsao   +9 more
doaj   +1 more source

Chemistry of phospholipid oxidation

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The oxidation of lipids has long been a topic of interest in biological and food sciences, and the fundamental principles of non-enzymatic free radical attack on phospholipids are well established, although questions about detail of the mechanisms remain.
Reis, Ana, Spickett, Corinne M.
openaire   +2 more sources

Lipid Bilayers Are Long-Lived on Solvent Cleaned Plasma-Oxidized poly(dimethyl)siloxane (ox-PDMS). [PDF]

PLoS ONE, 2017
Although it is well known that phospholipids self-assemble on hydrophilic plasma-oxidized PMDS surfaces (ox-PDMS) to form cell membrane mimetic bilayers, the temporal stability of phospholipid membranes on these surfaces is unknown.
K M Rifat Faysal, June S Park, Jonny Nguyen, Luis Garcia, Anand Bala Subramaniam   +4 more
doaj   +1 more source

Ellagitannin HeT obtained from strawberry leaves is oxidized by bacterial membranes and inhibits the respiratory chain [PDF]

, 2018
Plant secondary metabolism produces a variety of tannins that have a wide range of biological activities, including activation of plant defenses and antimicrobial, anti-inflammatory and antitumoral effects.
Abate, Pedro Oscar, Castagnaro, Atilio Pedro, Diaz Ricci, Juan Carlos, Filippone, María Paula, Katz, Néstor Eduardo, Mamani, Alicia Ines de Fatima, Martos, Gustavo Gabriel   +6 more
core   +1 more source

Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein

Journal of Lipid Research, 2001
Scavenger receptor class B type I (SR-BI) has been established as the primary mediator of the selective transfer of lipids from HDL to mammalian cells.
Kristin Gillotte-Taylor, Agnès Boullier, Joseph L. Witztum, Daniel Steinberg, Oswald Quehenberger   +4 more
doaj   +1 more source