Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. [PDF]
PLoS ONE, 2016 Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as ...
Boyi Liu +7 more
doaj +2 more sources
Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a) [PDF]
Journal of Lipid Research, 2015 Elevated lipoprotein (a) [Lp(a)] levels are a causal risk factor for coronary heart disease. Accumulating evidence suggests that Lp(a) can stimulate cellular inflammatory responses through the kringle-containing apolipoprotein (a) [apo(a)] component ...
Corey A. Scipione +6 more
doaj +2 more sources
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages [PDF]
Nature Communications, 2018 Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in
Lan H. Chu +7 more
doaj +2 more sources
Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2023 Brenna Appleton +2 more
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CHARMM GUI Membrane Builder for oxidized phospholipid membrane modeling and simulation [PDF]
Current Opinion in Structural BiologyDane E. Santa +2 more
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High-Density Lipoprotein Modulates Oxidized Phospholipid Signaling in Human Endothelial Cells From Proinflammatory to Anti-inflammatory [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Nima M. Gharavi +8 more
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Oxidized phospholipids: Biomarker for cardiovascular diseases [PDF]
The International Journal of Biochemistry & Cell Biology, 2008 Biologically active oxidized phospholipids can initiate and modulate many of the cellular events attributed to inflammation leading to atherosclerosis. Produced by enzymatic or non-enzymatic processes, these molecules interact with various cells via specific receptors and in general give rise to inflammatory signals. There is considerable evidence that
Mohammad Zahid Ashraf +2 more
openalex +4 more sources
Oxidized phospholipids and lipoprotein(a): An update [PDF]
European Journal of Clinical Investigation, 2021 AbstractOver the past few years, there has been an undiminished interest in lipoprotein(a) [Lp(a)] and oxidized phospholipids (OxPLs), mainly carried on this lipoprotein. Elevated Lp(a) has been established as an independent causal risk factor for cardiovascular disease. OxPLs play an important role in atherosclerosis. The main questions that remain to
Amalia Despoina Koutsogianni +3 more
openaire +2 more sources
In Vitro Digestion of Grape Seed Oil Inhibits Phospholipid-Regulating Effects of Oxidized Lipids
Biomolecules, 2020 The intake of dietary lipids is known to affect the composition of phospholipids in gastrointestinal cells, thereby influencing passive lipid absorption.
Sarah Fruehwirth +8 more
doaj +1 more source
Partial Mitigation of Oxidized Phospholipid-Mediated Mitochondrial Dysfunction in Neuronal Cells by Oxocarotenoids [PDF]
Journal of Alzheimer's Disease, 2020 Opeyemi S Ademowo +2 more
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