Results 51 to 60 of about 63,046 (336)

Mixing of oxidized and bilayer phospholipids

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
Composition and phase dependence of the mixing of 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), with the oxidized phospholipid, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) were investigated by characterizing the aggregation states of DPPC/PGPC and DOPC/PGPC using a fluorescence ...
Singh, Jasmeet, Ranganathan, Radha
openaire   +2 more sources

Role of Phospholipid Oxidation Products in Atherosclerosis [PDF]

Circulation Research, 2012
There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying
Sangderk, Lee, Konstantin G, Birukov, Casey E, Romanoski, James R, Springstead, Aldons J, Lusis, Judith A, Berliner   +5 more
openaire   +2 more sources

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]

, 2017
Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P, Hammock, Bruce D, Hennebelle, Marie, Kitson, Alex P, Lee, Kin Sing Stephen, Metherel, Adam H, Otoki, Yurika, Richardson, Christine E, Taha, Ameer Y, Yang, Jun, Zhang, Liang, Zhang, Zhichao   +11 more
core   +1 more source

Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice

Redox Biology, 2013
Background: The biologically active phospholipids Platelet-activating Factor (PAF) and oxidatively truncated phospholipids from chemical oxidation are increased in the circulation of rats subject to the oxidant stress of chronic ethanol ingestion ...
Jinbo Liu, Wei Li, Rui Chen, Thomas M. McIntyre   +3 more
doaj   +1 more source

Selenium in biology: Facts and medical perspectives [PDF]

, 2000
Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Brigelius-Flohé, Regina, Böck, August, Flohé, Leopold, Gärtner, Roland, Köhrle, Josef, Meyer, Ortwin   +5 more
core   +1 more source

The regulation of inflammation by oxidized phospholipids [PDF]

European Journal of Immunology, 2016
During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively modified. This process generates a complex mixture of structurally diverse oxidized phospholipid (OxPL) species, each of which may exert distinct biological effects.
openaire   +4 more sources

Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid

Journal of Lipid Research, 1999
Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I
Ingrid C. Gelissen, Kerry-Ann Rye, Andrew J. Brown, Roger T. Dean, Wendy Jessup   +4 more
doaj   +1 more source

Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease and valvular heart disease.
James L. Januzzi, Roland R. J. van Kimmenade, Yuxi Liu, Xingdi Hu, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, Ron Blankstein, Pradeep Natarajan   +8 more
doaj   +1 more source

Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System [PDF]

, 2010
Oxidative stresses from irritants such as hydrogen peroxide and ozone (O_3) can cause dysfunction of the pulmonary surfactant (PS) layer in the human lung, resulting in chronic diseases of the respiratory tract.
Beauchamp, J. L., Beegle, Luther W., Goddard, William A., III, Heath, James R., Jang, Seung Soon, Kanik, Isik, Kim, Hugh I., Kim, Hyungjun, Neidholdt, Evan L., Shin, Young Shik   +9 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source