Results 41 to 50 of about 203,353 (285)

Pleiotropic effects of oxidized phospholipids

Free Radical Biology and Medicine, 2017
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes.
Bochkov V, Gesslbauer B, Mauerhofer C, Philippova M, Erne P, Oskolkova OV   +5 more
openaire   +3 more sources

Correlation of Antiphospholipid Antibody Recognition with the Structure of Synthetic Oxidized Phospholipids IMPORTANCE OF SCHIFF BASE FORMATION AND ALDOL CONDENSATION* [PDF]

, 2002
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis through a variety of pathways. The process involves nonspecific fragmentation, oxidative breakdown, and modification of the lipids and protein of LDL.
Witztum, Joseph L, Dennis, Edward A, Steinberg, Daniel, Hörkkö, Sohvi, Friedman, Peter   +4 more
core   +1 more source

Generation and Biological Activities of Oxidized Phospholipids [PDF]

Antioxidants & Redox Signaling, 2010
Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPLs) markers of “
Valery N, Bochkov, Olga V, Oskolkova, Konstantin G, Birukov, Anna-Liisa, Levonen, Christoph J, Binder, Johannes, Stöckl   +5 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Phosphocholine as a pattern recognition ligand for CD361

Journal of Lipid Research, 2005
We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC)
Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R. Green, Felicidad Almazan, Edward A. Dennis, Daniel Steinberg, Joseph L. Witztum, Oswald Quehenberger   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine

Journal of Lipid Research, 2000
Plasmenyl phospholipids are a structurally unique class of lipids that contain a vinyl ether substituent at the sn-1 position of the glycerol backbone, imparting unique susceptibility to oxidative reactions that may take place at the cell membrane lipid ...
Nona Khaselev, Robert C. Murphy
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD[S]

Journal of Lipid Research, 2016
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone.
Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Victor Grijalva, Pallavi Mukherjee, Hannah R. Fogelman, Lin H. Hwang, Kym F. Faull, Aldons J. Lusis, Srinivasa T. Reddy, Alan M. Fogelman   +10 more
doaj   +1 more source

Role of Phospholipid Oxidation Products in Atherosclerosis [PDF]

Circulation Research, 2012
There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying
Sangderk, Lee, Konstantin G, Birukov, Casey E, Romanoski, James R, Springstead, Aldons J, Lusis, Judith A, Berliner   +5 more
openaire   +2 more sources