Results 61 to 70 of about 655,979 (316)

Phosphocholine as a pattern recognition ligand for CD361

Journal of Lipid Research, 2005
We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5′-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC)
Agnès Boullier, Peter Friedman, Richard Harkewicz, Karsten Hartvigsen, Simone R. Green, Felicidad Almazan, Edward A. Dennis, Daniel Steinberg, Joseph L. Witztum, Oswald Quehenberger   +9 more
doaj   +1 more source

TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells [PDF]

, 2018
Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation.
Bartholomew, Christopher, Biswas, Lincoln, Farhan, Fahad, Reilly, James, Shu, Xinhua   +4 more
core   +1 more source

Potential Causality and Emerging Medical Therapies for Lipoprotein(a) and Its Associated Oxidized Phospholipids in Calcific Aortic Valve Stenosis.

Circulation Research, 2019
The prevalence of calcific aortic valve disease is increasing with aging of the population. Current treatment options for advanced or symptomatic aortic stenosis are limited to traditional surgical or percutaneous aortic valve replacement.
S. Tsimikas
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine

Journal of Lipid Research, 2000
Plasmenyl phospholipids are a structurally unique class of lipids that contain a vinyl ether substituent at the sn-1 position of the glycerol backbone, imparting unique susceptibility to oxidative reactions that may take place at the cell membrane lipid ...
Nona Khaselev, Robert C. Murphy
doaj   +1 more source

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size [PDF]

, 2016
Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids ...
Abendschein, Dana, Gibson Dilthey, Beverly, Gross, Richard W, Guan, Shaoping, Jenkins, Christopher M, Kovacs, Attila, Liu, Xinping, Mancuso, David J, Moon, Sung Ho, Nguyen, Annie L, Sims, Harold F, Weinheimer, Carla J, Yang, Kui   +12 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD[S]

Journal of Lipid Research, 2016
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone.
Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Victor Grijalva, Pallavi Mukherjee, Hannah R. Fogelman, Lin H. Hwang, Kym F. Faull, Aldons J. Lusis, Srinivasa T. Reddy, Alan M. Fogelman   +10 more
doaj   +1 more source

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]

, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo, Bingqi Tong, BR Stockwell, Breanna Ford, Daniel K. Nomura, DL Tribble, DW Morgens, I Ingold, James A. Olzmann, JL Macdonald, Joseph M. Hendricks, K Bersuker, K Shimada, Kirill Bersuker, KR Marshall, L Magtanong, Leslie Magtanong, M Hayano, M Wu, Melissa A. Roberts, MG Rees, Michael C. Bassik, MJ Hangauer, Peter H. Tang, PH Tang, R Stocker, Roberto Zoncu, Scott J. Dixon, SJ Dixon, SJ Dixon, SJ Dixon, T Inoue, T Inoue, T Takahashi, TB Nguyen, Thomas J. Maimone, VS Viswanathan, WS Yang, WS Yang, X Sun, Y Ohiro, Y Zhang, Y Zou, Zhipeng Li   +43 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source