Results 71 to 80 of about 203,353 (285)

HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids

, 2001
—Oxidation of low density lipoprotein (LDL) phospholipids containing arachidonic acid at the sn -2 position occurs when a critical concentration of “seeding molecules” derived from the lipoxygenase pathway is reached in LDL.
Ganesamoorthy Subbanagounder, Srinivasa Reddy, Andrew D. Watson, Diana Shih, Deven Vora, Brian J. Van Lenten, Judith A. Berliner, Lawrence W. Castellani, Alan M. Fogelman, Susan Hama, Mohamad Navab, Aldons J. Lusis, Weibin Shi   +12 more
core   +1 more source

Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation[S]

Journal of Lipid Research, 2013
Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in inflammation. Their generation by cellular cyclooxygenases (COXs) is currently unknown.
Maceler Aldrovandi, Victoria J. Hammond, Helen Podmore, Martin Hornshaw, Stephen R. Clark, Lawrence J. Marnett, David A. Slatter, Robert C. Murphy, Peter W. Collins, Valerie B. O'Donnell   +9 more
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Total oxylipin concentrations in NIST SRM 1950 plasma compared to fresh and commercially obtained human plasma

Journal of Lipid Research
Oxylipins are oxidized PUFAs such as hydroxy-PUFAs and epoxy-PUFAs. Total oxylipins are commonly analyzed following base hydrolysis as nonesterified oxylipins by means of LC-MS/MS.
Nadja Kampschulte, Lilli Scholz, Theresa L. Pedersen, Isabel F. Snodgrass, John W. Newman, Nils Helge Schebb   +5 more
doaj   +1 more source

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1

Journal of Lipid Research, 2000
Apolipoprotein A-I (apoA-I) and an apoA-I peptide mimetic removed seeding molecules from human low density lipoprotein (LDL) and rendered the LDL resistant to oxidation by human artery wall cells.
Mohamad Navab, Susan Y. Hama, C. Justin Cooke, G.M. Anantharamaiah, Manjula Chaddha, Linda Jin, Ganesamoorthy Subbanagounder, Kym F. Faull, Srinivasa T. Reddy, Norman E. Miller, Alan M. Fogelman   +10 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3

Journal of Lipid Research, 2000
Treatment of human artery wall cells with apolipoprotein A-I (apoA-I), but not apoA-II, with an apoA-I peptide mimetic, or with high density lipoprotein (HDL), or paraoxonase, rendered the cells unable to oxidize low density lipoprotein (LDL).
Mohamad Navab, Susan Y. Hama, G.M. Anantharamaiah, Kholood Hassan, Greg P. Hough, Andrew D. Watson, Srinivasa T. Reddy, Alex Sevanian, Gregg C. Fonarow, Alan M. Fogelman   +9 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source