Role of Phospholipid Oxidation Products in Atherosclerosis [PDF]
Circulation Research, 2012 There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying
Sangderk, Lee +5 more
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Oxidized phospholipid damage signals as modulators of immunity
Open BiologyDamage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, become oxidized under conditions of cellular stress ...
Joon H. Choi, Jonathan C. Kagan
doaj +1 more source
Emulsifier and antioxidant properties of by-products obtained by enzymatic degumming of soybean oil [PDF]
, 2013 The enzymes used in degumming, called phospholipases, specifically act on phospholipids without degrading the oil itself. Degumming using a phospholipase C enzyme allows to meet all market specifications while it increases the oil yield.
AOCS +28 more
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A novel role for 12/15-lipoxygenase in regulating autophagy
Redox Biology, 2015 12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material ...
Alwena H. Morgan +8 more
doaj +1 more source
Studies on ferrous ion-induced lipid peroxidation of rat liver mitochondria. I. Effect of inorganic phosphate [PDF]
, 1974 Effect of inorganic phosphate on ferrous ion- and ascorbate-induced lipid. peroxidations of isolated rat liver mitochondria was investigated. As a result it has been shown that phosphate accelerates the ferrous ion.induced lipid peroxidation; namely ...
Hashimoto, Gonosuke +4 more
core +1 more source
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
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The regulation of inflammation by oxidized phospholipids [PDF]
European Journal of Immunology, 2016 During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively modified. This process generates a complex mixture of structurally diverse oxidized phospholipid (OxPL) species, each of which may exert distinct biological effects.
openaire +4 more sources
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]
, 2017 Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B. +10 more
core +3 more sources
Science Signaling, 2019 Enzymatically oxidized phospholipids have important functions in normal physiology and disease states. Gloss Lipids that are generated by enzymes in circulating blood cells through controlled oxidation of biomembranes have been discovered.
V. O’Donnell +3 more
semanticscholar +1 more source