Results 81 to 90 of about 203,353 (285)

Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions

, 2002
— Membrane vesicles (MVs) released from activated cells and blebs from apoptotic cells are increased in patients with vascular disease and in those with atherosclerotic lesions, and their ...
Joseph L. Witztum, Bernd R. Binder, Goran Mitulovic, Anja Vales, Rainer Schmid, Joakim Huber, Michael Blumer, Norbert Leitinger   +7 more
core   +1 more source

Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin [PDF]

, 2012
Oxidized phospholipid species are important, biologically relevant, lipid signaling molecules that usually exist in low abundance in biological tissues.
Bayır, Hülya, Kagan, Valerian E., Shvedova, Anna A., Ji, Jing, Samhan-Arias, Alejandro K., Greenberger, Joel S., Sparvero, Louis J., Amoscato, Andrew A., Tyurin, Vladimir, Demidova, Olga M., Tyurina, Yulia Y., Feng, Weihong, Epperly, Michael W.   +12 more
core   +1 more source

Emerging Role of Oxidized Phospholipids in Tumor Biology

healthbook TIMES. Oncology Hematology
Oxidized phospholipids (OxPLs) are biologically active products of lipid peroxidation that accumulate in the tumor milieu as a consequence of oxidative stress, cell death and metabolic alterations.
Marija Jelic, Olga V. Oskolkova, Valery Bochkov   +2 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Evaluation of oxidized phospholipids analysis by LC-MS/MS

, 2017
Phospholipids (PLs) represent a class of metabolites of interest for evaluating the relationship between diet and the development of several metabolic diseases. Given that PLs are rich in unsaturated fatty acids, they can be oxidized.
Bernard Lyan, Spiro Khoury, Khoury, Spiro, Estelle Pujos-Guillot, Pujos-Guillot, Estelle, Lyan, Bernard, Pouyet, Corinne, Corinne Pouyet   +7 more
core   +1 more source

Regulation of Platelet-Activating Factor Acetylhydrolase by Oxidized Phospholipids and Proinflammatory Cytokines [PDF]

, 2008
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a monocyte-derived phospholipase A2 that catalyzes the hydrolysis of platelet-activating factor (PAF) and has been implicated in atherosclerosis.
Mukkamala, Muralikrishna
core   +1 more source

Evaluation of the Mechanisms of Mayonnaise Phospholipid Oxidation

Journal of Oleo Science, 2017
Mayonnaise, which is widely used in foods, is rich in lipids and therefore susceptible to oxidation during the manufacturing process, which can result in loss of quality. Herein, we detected and analyzed phosphatidylcholine hydroperoxide (PCOOH) isomers present in fresh mayonnaise using LC-MS/MS.
Kato, Shunji, Iseki, Tatsuya, Hanzawa, Yasuhiko, Otoki, Yurika, Ito, Junya, Kimura, Fumiko, Miyazawa, Teruo, Nakagawa, Kiyotaka   +7 more
openaire   +3 more sources

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

, 2012
Objective: Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation.
Ahnstrom, Josefin, Heinecke, Jay W, Jay W. Heinecke, Binder, Christoph J., Peter Plomgaard, Christoffersen, Christina, Christina Christoffersen, Plomgaard, Peter, Björn Dahlbäck, Elsøe, Sara, Dahlbäck, Björn, Heinecke, Jay W., Elsoe, Sara, Björkbacka, Harry, Björkbacka, Harry,, Binder, Christoph J, Hoofnagle, Andrew N., Josefin Ahnström, Sara Elsøe, Lars B. Nielsen, Andrew N. Hoofnagle, Christoph J. Binder, Hoofnagle, Andrew N, Dahlbäck, Björn,, Nielsen, Lars Bo, Nielsen, Lars B., Harry Björkbacka, Lund University.   +27 more
core   +1 more source